MIV-6
MIV-6 is a small molecule inhibitor that inhibits menin-mixed lineage leukemia (MLL) interaction and exhibits strong selective activity in MLL leukemia cells with IC50 = 56 nM.
For research use only. We do not sell to patients.
- CAS No.: 1560968-27-5
- Formula: C27H35N3O
- Molecular Weight:417.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Bone marrow cell | GI50 |
1.1 μM
Compound: 19, MIV-6
|
Growth inhibition of mouse bone marrow cells expressing MLL-AF9 after 7 days by MTT assay
Growth inhibition of mouse bone marrow cells expressing MLL-AF9 after 7 days by MTT assay
|
[PMID: 24472025] |
| MOLM-13 | GI50 |
3.7 μM
Compound: 19, MIV-6
|
Growth inhibition of human MOLM13 cells harboring MLL-AF9 after 7 days by MTT assay
Growth inhibition of human MOLM13 cells harboring MLL-AF9 after 7 days by MTT assay
|
[PMID: 24472025] |
| MV4-11 | GI50 |
2.8 μM
Compound: 19, MIV-6
|
Growth inhibition of human MV411 cells harboring MLL-AF4 after 7 days by MTT assay
Growth inhibition of human MV411 cells harboring MLL-AF4 after 7 days by MTT assay
|
[PMID: 24472025] |
| MV4-11 | IC50 |
3.6 μM
Compound: 4; MIV-6
|
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
|
[PMID: 31244110] |
Chemical Information
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CAS No. 1560968-27-5
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Molecular Weight 417.59
-
Formula C27H35N3O
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SMILES
N#CC1=CC=C(OCCCN2CCC(C(C3CCCC3)(N)C4=CC=CC=C4)CC2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)