1. Metabolic Enzyme/Protease
  2. Nampt
  3. Nampt-IN-5

Nampt-IN-5 

Cat. No.: HY-130606
Handling Instructions

Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively.

For research use only. We do not sell to patients.

Nampt-IN-5 Chemical Structure

Nampt-IN-5 Chemical Structure

CAS No. : 2380013-17-0

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Description

Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1].

IC50 & Target

IC50: Nampt[1]

In Vitro

Nampt-IN-5 (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1].
Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min*mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6[1].

Molecular Weight

427.50

Formula

C₂₅H₂₅N₅O₂

CAS No.

2380013-17-0

SMILES

O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Nampt-IN-5NamptNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorA2780 COR-L23Inhibitorinhibitorinhibit

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