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Cat. No.: HY-170393

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iBFAR2

iBFAR2, a BFAR inhibitor, restores the CD8+ TRM cell subset against solid tumors. iBFAR2 promotes JAK2-STAT1 association and STAT1 phosphorylation.

For research use only. We do not sell to patients.

Purity : 97.24%
CAS No.: 353484-02-3
Formula: C₁₉H₁₅F₃N₂O₂
Molecular Weight:360.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

iBFAR2 Chemical Structure

CAS No.: 353484-02-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

iBFAR2, a BFAR inhibitor, restores the CD8+ TRM cell subset against solid tumors. iBFAR2 promotes JAK2-STAT1 association and STAT1 phosphorylation^[1].

All JAK Isoforms :

All STAT Isoforms :

In Vitro

iBFAR2 abolishes USP39 ubiquitination, inhibits the JAK2-USP39 interaction and thus suppresses JAK2 deubiquitination, thereby promoting JAK2-STAT1 association and STAT1 phosphorylation in mouse primary CD8+ T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

iBFAR2 (ip, 1, 5, 10 mg/kg, once every 2 days starting from day 7 (n = 9 mice/group)) suppresses MB49 tumor growth in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 353484-02-3
Appearance Solid
Molecular Weight 360.33
Formula C₁₉H₁₅F₃N₂O₂
Color Light yellow to yellow
SMILES

FC(F)(F)C1=CC=CC2=C1NC(C3=CC=C([N+]([O-])=O)C=C3)C4C2C=CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siyu Pei, et al. Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity. Nat Aging. 2024 Dec;4(12):1828-1844. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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iBFAR2

All JAK Isoforms

All STAT Isoforms