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Cat. No.: HY-116294

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Methoctramine

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Methoctramine is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine can be used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 104807-40-1
Formula: C₃₆H₆₂N₄O₂
Molecular Weight:582.90

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

Methoctramine Chemical Structure

CAS No.: 104807-40-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
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Publications (1)
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Biological Activity

Description

All mAChR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Astrocyte	EC₅₀	0.0845 μM Compound: 31	Antiproliferative activity against mouse astrocyte cells by MTT assay Antiproliferative activity against mouse astrocyte cells by MTT assay	[PMID: 17417631]
HeLa	IC₅₀	>100 μM Compound: 1, methoctramine	Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by trypan blue exclusion assay Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by trypan blue exclusion assay	[PMID: 23887056]
Oocyte	IC₅₀	138 nM Compound: 1	Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay	[PMID: 23692871]
Thymocyte	IC₅₀	>100 μM Compound: 1, methoctramine	Cytotoxicity against rat thymocytes assessed as cell survival after 24 hrs by trypan blue exclusion assay Cytotoxicity against rat thymocytes assessed as cell survival after 24 hrs by trypan blue exclusion assay	[PMID: 23887056]

Chemical Information

CAS No. 104807-40-1
Molecular Weight 582.90
Formula C₃₆H₆₂N₄O₂
SMILES

COC1=CC=CC=C1CNCCCCCCNCCCCCCCCNCCCCCCNCC2=CC=CC=C2OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Pharmaceuticals (Basel)

Ethanolic Extracts of Cupressaceae Species Conifers Provide Rapid Protection against Barium Chloride-Induced Cardiac Arrhythmia. [Abstract]

2024 Jul 29;17(8):1003. PMID: 39204108

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192(1):63-70. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Methoctramine

1 Cited Publications

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Biological Activity
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Methoctramine

Publications Citing Use of MedChemExpress (MCE) Methoctramine

All mAChR Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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Methoctramine Related Classifications

HY-116294 Related Classifications