Phe-PEG1-Dasa

Cat. No.: HY-180962: Data Sheet Handling Instructions
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Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader, with its DC₅₀ being 1.56 nM. Phe-PEG1-Dasa uses a single amino acid (Phe) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, thus being called a mini-PROTAC. Phe-PEG1-Dasa significantly inhibits the proliferation of K562 cells. Phe-PEG1-Dasa can be used for the study of leukemia.
(Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0215); Black: linker).

For research use only. We do not sell to patients.

Phe-PEG1-Dasa Chemical Structure

CAS No. : 3037776-73-8

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Purity & Documentation
References
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Description

Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader, with its DC₅₀ being 1.56 nM. Phe-PEG1-Dasa uses a single amino acid (Phe) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, thus being called a mini-PROTAC. Phe-PEG1-Dasa significantly inhibits the proliferation of K562 cells. Phe-PEG1-Dasa can be used for the study of leukemia^[1]. (Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0215); Black: linker).

IC₅₀ & Target^[1]

Bcr-Abl

1.56 nM (DC₅₀)

Molecular Weight

750.31

Formula

C₃₆H₄₄ClN₉O₅S

CAS No.

3037776-73-8

SMILES

N[C@@H](CC1=CC=CC=C1)C(NCCOCCC(OCCN(CC2)CCN2C3=NC(C)=NC(NC4=NC=C(C(NC5=C(C=CC=C5Cl)C)=O)S4)=C3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]

Phe-PEG1-Dasa Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phe-PEG1-Dasa3037776-73-8PROTACsBcr-AblPROTACN-end rule pathwayDegronmini-PROTACLinker-freeAmino acidsUbiquitin ligaseInhibitorinhibitorinhibit

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