Phe-PEG1-Dasa
Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader, with its DC50 being 1.56 nM. Phe-PEG1-Dasa uses a single amino acid (Phe) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, thus being called a mini-PROTAC. Phe-PEG1-Dasa significantly inhibits the proliferation of K562 cells. Phe-PEG1-Dasa can be used for the study of leukemia.
(Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0215); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3037776-73-8
- Formula: C36H44ClN9O5S
- Molecular Weight:750.31
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
Bcr-Abl 1.56 nM (DC50) |
Chemical Information
-
CAS No. 3037776-73-8
-
Molecular Weight 750.31
-
Formula C36H44ClN9O5S
-
SMILES
N[C@@H](CC1=CC=CC=C1)C(NCCOCCC(OCCN(CC2)CCN2C3=NC(C)=NC(NC4=NC=C(C(NC5=C(C=CC=C5Cl)C)=O)S4)=C3)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz