PI3K-IN-37
Based on 1 Customer Validation
PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM).
For research use only. We do not sell to patients.
- Purity : 99.0%
- CAS No.: 1257547-40-2
- Formula: C25H26N6O2
- Molecular Weight:442.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PI3Kδ 4 nM (IC50) |
mTOR 4 nM (IC50) |
PI3Kα 6 nM (IC50) |
PI3Kβ 8 nM (IC50) |
In Vitro
PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1].
PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Rat1 cells
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Concentration:0.005-10 μM
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Incubation Time:30 min
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Result:Inhibited Pl3-kinase isoforms alpha, beta or delta phosphorylation with the IC50s of <5 nM, 8 nM, and 18 nM, respectively.
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Cell Line:TSC1-/- MEF cells
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Concentration:0.005-1 μM
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Incubation Time:60 min
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Result:Inhibited S6 Ribosomal Protein phosphorylation (IC50=2 nM).
Chemical Information
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CAS No. 1257547-40-2
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Appearance Solid
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Molecular Weight 442.51
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Formula C25H26N6O2
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Color Light yellow to light brown
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SMILES
O=C1N(C2=C(N1C)C=NC3=CC=C(C4=CC(OC(C)C)=C(C)N=C4)C=C23)C5=CN(C)N=C5C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K-IN-37 Related Classifications
HY-147284 Related Classifications
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