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Prothipendyl

Prothipendyl is a tricyclic azaphenothiazine neuroleptic agent. Prothipendyl is a substrate of the CYP isozymes CYP1A2, CYP2D6, CYP2C19 and CYP3A4. Prothipendyl has sedating and psychomotorically damping effects. Prothipendyl can be used for psychomotoric agitation, sleep disorder and anxiety research .

For research use only. We do not sell to patients.

CAS No.: 303-69-5
Formula: C₁₆H₁₉N₃S
Molecular Weight:285.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Prothipendyl Chemical Structure

CAS No.: 303-69-5

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Cytochrome P450 Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
C32	IC₅₀	>=23 μg/mL Compound: Prothipendyl	Cytotoxicity against human C32 cells incubated for 72 hrs by WST1 dye based assay Cytotoxicity against human C32 cells incubated for 72 hrs by WST1 dye based assay	[PMID: 28734245]
HFF-1	IC₅₀	>=23 μg/mL Compound: Prothipendyl	Cytotoxicity against human HFF1 cells incubated for 72 hrs by WST1 dye based assay Cytotoxicity against human HFF1 cells incubated for 72 hrs by WST1 dye based assay	[PMID: 28734245]
MCF7	IC₅₀	>=23 μg/mL Compound: Prothipendyl	Cytotoxicity against human MCF7 cells incubated for 72 hrs by WST1 dye based assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by WST1 dye based assay	[PMID: 28734245]
SNB-19	IC₅₀	>=23 μg/mL Compound: Prothipendyl	Cytotoxicity against human SNB19 cells incubated for 72 hrs by WST1 dye based assay Cytotoxicity against human SNB19 cells incubated for 72 hrs by WST1 dye based assay	[PMID: 28734245]
T47D	IC₅₀	32.3 μg/mL Compound: Prothipendyl	Cytotoxicity against human T47D cells Cytotoxicity against human T47D cells	[PMID: 28734245]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 303-69-5
Molecular Weight 285.41
Formula C₁₆H₁₉N₃S
SMILES

CN(C)CCCN1C2=NC=CC=C2SC3=CC=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Krämer M, et al. Range of therapeutic prothipendyl and prothipendyl sulfoxide concentrations in clinical blood samples. Drug Test Anal. 2018 Jun;10(6):1009-1016. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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