(S)-JWZ-5-13
Based on 1 Customer Validation
(S)-JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13 (HY-161828). (S)-JWZ-5-13 displays similar in vitro CDK7 inhibition (IC50 = 21.1 nM) to JWZ-5-13, but fails to induce CDK7 degradation in cells.
(Pink: CDK7 ligand (HY-161830); Blue: Ligands for E3 Ligase ligand (HY-112078B); Black: linker (HY-Y0925)).
For research use only. We do not sell to patients.
- Purity: 99.62%
- Formula: C54H66N10O6S
- Molecular Weight:983.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Clinical Compound Library
HY-L026
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Anti-Aging Compound Library
HY-L034
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Drug Repurposing Compound Library
HY-L035
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Anti-Blood Cancer Compound Library
HY-L079
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PROTAC Library
HY-L151
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Anti-Hematopathy Compound Library
HY-L171
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
HY-L026P
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Protein Kinase Compound Library
HY-L196
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
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Alkyne Compound Library
HY-L258
All PROTACs Isoforms
More
Biological Activity
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CDK7 21.1 nM (IC50) |
Chemical Information
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Appearance Solid
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Molecular Weight 983.23
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Formula C54H66N10O6S
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Color White to off-white
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SMILES
O=C(NC1=NNC2=C1CN(C(N[C@@H](C3=CC=CC=C3)CN(C)C)=O)C2(C)C)C4=CC=C(C#CCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (101.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0171 mL | 5.0853 mL | 10.1706 mL | 25.4264 mL |
| 5 mM | 0.2034 mL | 1.0171 mL | 2.0341 mL | 5.0853 mL | |
| 10 mM | 0.1017 mL | 0.5085 mL | 1.0171 mL | 2.5426 mL | |
| 15 mM | 0.0678 mL | 0.3390 mL | 0.6780 mL | 1.6951 mL | |
| 20 mM | 0.0509 mL | 0.2543 mL | 0.5085 mL | 1.2713 mL | |
| 25 mM | 0.0407 mL | 0.2034 mL | 0.4068 mL | 1.0171 mL | |
| 30 mM | 0.0339 mL | 0.1695 mL | 0.3390 mL | 0.8475 mL | |
| 40 mM | 0.0254 mL | 0.1271 mL | 0.2543 mL | 0.6357 mL | |
| 50 mM | 0.0203 mL | 0.1017 mL | 0.2034 mL | 0.5085 mL | |
| 60 mM | 0.0170 mL | 0.0848 mL | 0.1695 mL | 0.4238 mL | |
| 80 mM | 0.0127 mL | 0.0636 mL | 0.1271 mL | 0.3178 mL | |
| 100 mM | 0.0102 mL | 0.0509 mL | 0.1017 mL | 0.2543 mL |
(S)-JWZ-5-13 Related Classifications
HY-161828A Related Classifications
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