2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. (S)-JWZ-5-13

(S)-JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13 (HY-161828). (S)-JWZ-5-13 displays similar in vitro CDK7 inhibition (IC50 = 21.1 nM) to JWZ-5-13, but fails to induce CDK7 degradation in cells.
(Pink: Ligands for Target Protein for PROTAC ligand (HY-161830); Blue: Ligands for E3 Ligase ligand (HY-112078B); Black: linker (HY-Y0925)).

For research use only. We do not sell to patients.

(S)-JWZ-5-13

(S)-JWZ-5-13 Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-JWZ-5-13:

(S)-JWZ-5-13 Related Antibodies

Top Publications Citing Use of Products

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

(S)-JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13 (HY-161828). (S)-JWZ-5-13 displays similar in vitro CDK7 inhibition (IC50 = 21.1 nM) to JWZ-5-13, but fails to induce CDK7 degradation in cells[1]. (Pink: Ligands for Target Protein for PROTAC ligand (HY-161830); Blue: Ligands for E3 Ligase ligand (HY-112078B); Black: linker (HY-Y0925)).

IC50 & Target[1]

CDK7

21.1 nM (IC50)

Molecular Weight

983.23

Formula

C54H66N10O6S
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NNC2=C1CN(C(N[C@@H](C3=CC=CC=C3)CN(C)C)=O)C2(C)C)C4=CC=C(C#CCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (101.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0171 mL 5.0853 mL 10.1706 mL
5 mM 0.2034 mL 1.0171 mL 2.0341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0171 mL 5.0853 mL 10.1706 mL 25.4264 mL
5 mM 0.2034 mL 1.0171 mL 2.0341 mL 5.0853 mL
10 mM 0.1017 mL 0.5085 mL 1.0171 mL 2.5426 mL
15 mM 0.0678 mL 0.3390 mL 0.6780 mL 1.6951 mL
20 mM 0.0509 mL 0.2543 mL 0.5085 mL 1.2713 mL
25 mM 0.0407 mL 0.2034 mL 0.4068 mL 1.0171 mL
30 mM 0.0339 mL 0.1695 mL 0.3390 mL 0.8475 mL
40 mM 0.0254 mL 0.1271 mL 0.2543 mL 0.6357 mL
50 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.5085 mL
60 mM 0.0170 mL 0.0848 mL 0.1695 mL 0.4238 mL
80 mM 0.0127 mL 0.0636 mL 0.1271 mL 0.3178 mL
100 mM 0.0102 mL 0.0509 mL 0.1017 mL 0.2543 mL
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(S)-JWZ-5-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-JWZ-5-13PROTACsCDKCyclin dependent kinasePROTACCDK7Inhibitorinhibitorinhibit

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