RVG
Based on 1 publication(s) in Google Scholar
RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 115136-25-9
- Formula: C141H217N43O43S2
- Molecular Weight:3266.62
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) RVG
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Biological Activity
RVG (500 ng/mL; 4 h) induces a basal level of IL-2 response in co-cultured BB7-T cell hybridomas with mouse bone marrow-derived dendritic cells (BMDCs)[1].
RVG (1 μg/mL; 4 h) induces a non-specific, MG132-independent basal IL-2 response in co-cultured F9A6-T cell hybridomas in human THP-1-derived macrophages[1].
At concentrations of 0.5-5.0 μg/mL for 4 h, RVG slightly increases the proportion of IL-12-secreting cells in mouse bone marrow-derived dendritic cells (BMDCs) compared with the unstimulated control group, but causes no dose-dependent enhancement of IL-12 secretion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (6-week-old female)[1]
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Dosage:10 µg (s.c.); 10 µg (i.n.)
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Administration:s.c.; three doses at 14-day intervals; i.n.; three doses at 14-day intervals
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Result:Exhibited 85B241 peptide-specific IFN-γ producing splenocyte counts not significantly different from counts in mice immunized with 85B241 alone via subcutaneous route.
Produced IFN-γ, IL-2, and TNF-α levels upon in vitro restimulation with 85B241 peptide not significantly different from levels in mice immunized with 85B241 alone.
Induced 85B241-specific IgG levels with no significant difference compared to mice immunized with 85B241 alone via subcutaneous route; induced no detectable 85B241-specific IgG via intranasal route.
Chemical Information
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CAS No. 115136-25-9
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Appearance Solid
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Molecular Weight 3266.62
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Formula C141H217N43O43S2
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Color White to off-white
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Synonyms
RVG29; RDP; Rabies Virus Glycoprotein-29
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Sequence
Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly
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Sequence Shortening
YTIWMPENPRPGTPCDIFTNSRGKRASNG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via the PINK1/Parkin pathway. [Abstract]2025 Dec 23:245:201-222. PMID: 41448258
Solvent & Solubility
DMSO : 10 mg/mL (3.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Garnica O, et al. Enhanced delivery of Mycobacterium tuberculosis antigens to antigen presenting cells using RVG peptide. Tuberculosis (Edinb). 2019 May;116S:S34-S41. [Content Brief]
[2]. Hou J, et al. α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via the PINK1/Parkin pathway. Free Radic Biol Med. 2026;245:201-222. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3061 mL | 1.5306 mL | 3.0613 mL | 7.6532 mL |
RVG Related Classifications
HY-P5623 Related Classifications
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