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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
288 Results for "
zebrafish 53BP1
" in MedChemExpress (MCE) Product Catalog:
Products (288)
288 Results for "zebrafish 53BP1" in MCE Product Catalog:
Cat. No.: HY-W012278
CAS No.: 56-55-3
Synonyms: Tetraphene
Research Areas:
Benz[a]anthracene (Tetraphene) is a polycyclic aromatic hydrocarbon pollutant and also a ligand of aryl hydrocarbon receptor 2 (AHR2), with a pIC50 of 7.319. Benz[a]anthracene can be detected in spruce needles near aluminum smelters. Exposure to Benz[a]anthracene during zebrafish embryonic stage activates the AHR-CYP1A signaling pathway and induces AHR2 expression, leading to social behavioral deficits that persist into adulthood, accompanied by impaired neuro-immune interaction, while anxiety levels remain unaffected. Benz[a]anthracene can be used in studies related to PAH environmental toxicology, developmental neurotoxicity and biodegradation .
Cat. No.: HY-P70935
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EPDR1; Upregulated In Colorectal Cancer Gene 1 Protein; Ependymin Related 1; Mammalian Ependymin-Related Protein 1; MERP-1; Ependymin Related Protein 1 (zebrafish); MERP1; Mammalian Ependymin Related Protein 1; UCC1; Ependymin Related Protein 1; EPDR
Species:
Human
Source:
HEK293
Cat. No.: HY-P79426
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ISM1; ISM; Prev. C20orf82; Isthmin 1 Homolog (zebrafish); BA149I18.1; Isthmin 1 Homolog; Isthmin 1, Angiogenesis Inhibitor; DJ1077I2.1; Isthmin-1; Isthmin; Isthmin 1; Chromosome 20 Open Reading Frame 82
Species:
Human
Source:
HEK293
Cat. No.: HY-104044A
CAS No.: 2086689-94-1
Synonyms: BGB-290 maleate
Target:
Research Areas:
Pamiparib maleate (BGB-290 maleate) is a highly potent and selective PARP inhibitor with neurotoxicity-inducing activity. Pamiparib maleate can effectively penetrate the blood-brain barrier and cause cerebral hemorrhage, brain atrophy, and movement disorders in zebrafish embryos exposed. Pamiparib maleate exposure downregulates the activities of acetylcholinesterase (AChE) and adenosine triphosphatase (ATPase) and leads to upregulation of oxidative stress, which triggers apoptosis and interferes with the expression of neurodevelopment-related genes. The use of pamiparib maleate is also accompanied by downregulation of the Notch signaling pathway, while activation of the Notch signaling pathway can partially rescue neurodevelopmental toxicity. Therefore, pamiparib maleate provides a reference for evaluating its potential neurotoxicity during embryonic development .
Target:
Research Areas:
NCRW0005-F05 is a GPR139 antagonist with an IC50 of 147.9 nM against zebrafish GPR139. NCRW0005-F05 blocks agonist-induced GPR139 activity and inhibits intracellular calcium mobilization. NCRW0005-F05 suppresses fear memory consolidation, increases and decreases the peak amplitude of calcium transients, reduces KCl-induced calcium transients, induces thigmotaxis, and decreases locomotor speed after conditioning. NCRW0005-F05 can be used in research related to Parkinson's disease, diabetes, and obesity .
Cat. No.: HY-161783
CAS No.: 3048532-05-1
Research Areas:
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability .
Cat. No.: HY-163982
Research Areas:
FOXJ1 agonist 1 (compound 16c) is an orally effective small molecule that can effectively enhance the expression of FOXJ1. Foxj1-IN-1 acts on the mammalian airway system composed of multiciliated cells (MCC) to prevent the development and onset of chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 can induce the production of motile cilia in the respiratory system of zebrafish and mammals, and inhibit elastase-induced COPD mouse models. Foxj1-IN-1 has good liver microsomal stability, in vivo PK curve and AUC; it has no significant inhibition of CYP and hERG, and does not have significant cytotoxicity .
Cat. No.: HY-178016
CAS No.: 3097193-89-7
Target:
Research Areas:
H3R antagonist 8 is a selective nonimidazole histamine H3 receptor antagonist (IC50 = 0.35 μM). H3R antagonist 8 exhibits hERG channel blockade activity (IC50 = 0.67 μM). H3R antagonist 8 inhibits seizures by antagonizing H3 receptor. H3R antagonist 8 reduces tonic hind limb extension (THLE) in mice in the maximal electroshock seizure (MES) model (ED50 = 20.21 mg/kg) and and shortens pentylenetetrazol (PTZ)-induced total movement distance in AB strain zebrafish larvae. H3R antagonist 8 can be used for the study of epilepsy .
Cat. No.: HY-21191S
CAS No.: 2708218-84-0
Synonyms: PFBS-13C3 sodium
Cat. No.: HY-W012352R
CAS No.: 605-32-3
Cat. No.: HY-P75680
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CNPY3; PRAT4A; Prev. TNRC5; Protein Associated With Toll-Like Receptor 4A; CAG4A; Trinucleotide Repeat Containing 5; Trinucleotide Repeat-Containing Gene 5 Protein; Canopy 3 Homolog (zebrafish); Expanded Repeat-Domain Protein CAG/CTG 5; CAG Repeat Contain
Species:
Human
Source:
HEK293
Cat. No.: HY-P76273
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CNPY3; PRAT4A; Prev. TNRC5; Protein Associated With Toll-Like Receptor 4A; CAG4A; Trinucleotide Repeat Containing 5; Trinucleotide Repeat-Containing Gene 5 Protein; Canopy 3 Homolog (zebrafish); Expanded Repeat-Domain Protein CAG/CTG 5; CAG Repeat Contain
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76274
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CNPY3; PRAT4A; Prev. TNRC5; Protein Associated With Toll-Like Receptor 4A; CAG4A; Trinucleotide Repeat Containing 5; Trinucleotide Repeat-Containing Gene 5 Protein; Canopy 3 Homolog (zebrafish); Expanded Repeat-Domain Protein CAG/CTG 5; CAG Repeat Contain
Species:
Mouse
Source:
HEK293
Target:
Cat. No.: HY-117733
CAS No.: 176050-48-9
Cat. No.: HY-W017424
CAS No.: 136-95-8
Target:
Research Areas:
2-Aminobenzothiazole acts as a caspase 3/7 activator, an anticancer cytotoxic agent, and also exhibits neurotoxicity. 2-Aminobenzothiazole drives the apoptotic pathway by activating caspase 3/7, induces mitochondrial inner membrane depolarization, and triggers both early and late apoptosis via a caspase-dependent pathway. In zebrafish models, 2-Aminobenzothiazole induces oxidative damage in brain tissues and inhibits genes related to GABA and 5-HT synthesis pathways. Long-term exposure to 2-Aminobenzothiazole impairs motor ability, social behavior, anxiety-like state and cognitive function. 2-Aminobenzothiazole can be used in studies of human laryngeal carcinoma and related neurotoxicity .
Synonyms: 15-keto-PGE2
Cat. No.: HY-119976S
CAS No.: 2468796-76-9
Cat. No.: HY-147209
Target:
Research Areas:
DC-TEAD3in03 is a subtype-selective and covalent TEAD3 inhibitor with an IC50 of 0.16 μM. DC-TEAD3in03 exhibits the inhibitory activity on TEAD1/2/4 reduced by more than 100 times. DC-TEAD3in03 has the IC50 for TEAD3 of 1.15 μM in the GAL4-TEAD reporter gene experiment in cells, and it does not interfere with the β-catenin pathway. DC-TEAD3in03 reduces the growth rate of the zebrafish tail fin. DC-TEAD3in03 can be used to study the proportional growth of appendages in vertebrates .
Cat. No.: HY-147412
CAS No.: 2642382-41-8
Synonyms: QR-421a
Research Areas:
Ultevursen (QR-421a) is a splice-modulating antisense oligonucleotide targeting exon 13 of the USH2A gene, which restores the functional expression of Usherin protein by inducing exon skipping. Ultevursen binds to USH2A pre-mRNA and modulates the splicing process to specifically skip exon 13 carrying the pathogenic mutation c.2299delG, generating an in-frame transcript and a truncated yet functionally normal protein. Ultevursen exhibits concentration-dependent exon skipping activity in human cells and retinal organoid models, and restores Usherin expression and retinal function in zebrafish and gene-edited mouse models. Ultevursen can be used for related research on type 2 Usher syndrome and non-syndromic retinitis pigmentosa .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
