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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3429 Results for "
substrates
" in MedChemExpress (MCE) Product Catalog:
Products (3429)
3429 Results for "substrates" in MCE Product Catalog:
Cat. No.: HY-B0168BS
Synonyms: (1S,2R)-Milnacipran-d5 hydrochloride; F-2695-d5 hydrochloride
Research Areas:
Quinidine sulfate is an orally active antiarrhythmic agent. Quinidine sulfate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine sulfate exerts sustained block and open-channel block effects on IK(f). Quinidine sulfate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine sulfate can be used in studies related to uterine sarcoma and seizures .
Cat. No.: HY-B1751E
CAS No.: 27555-34-6
Research Areas:
Quinidine polygalacturonate is an orally active antiarrhythmic agent. Quinidine polygalacturonate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine polygalacturonate exerts sustained block and open-channel block effects on IK(f). Quinidine polygalacturonate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine polygalacturonate can be used in studies related to uterine sarcoma and seizures .
Research Areas:
Quinidine gluconic acid is an orally active antiarrhythmic agent. Quinidine gluconic acid reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine gluconic acid exerts sustained block and open-channel block effects on IK(f). Quinidine gluconic acid alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine gluconic acid can be used in studies related to uterine sarcoma and seizures .
Cat. No.: HY-D2477A
Target:
Research Areas:
Sulfo-QSY21-NHS DIEA is an N-hydroxysuccinimide ester derivative fluorescent quencher that reduces the fluorescence intensity of paired fluorophores via proximity effect and relieves quenching after linker extension induced by mechanical force. Sulfo-QSY21-NHS DIEA can label streptavidin through NHS ester bioconjugation and be integrated into fluorescence-based molecular tension sensors to map the mechanical forces of cell surface receptors. Sulfo-QSY21-NHS DIEA also serves as a quencher for cysteine cathepsin-targeted quenched fluorescent substrate probes, and is widely used in studies related to breast cancer, colorectal cancer and lung adenocarcinoma .
Cat. No.: HY-D3442
CAS No.: 3121565-89-4
Research Areas:
ALDH2 probe 5 is a ALDH2 isoform-selective fluorescent probe with an emission wavelength centered at 494 nm. ALDH2 probe 5 is a turn-on fluorescent substrate for ALDH2; in its unreacted aldehyde form, twisted intramolecular charge transfer (TICT) occurs, resulting in fluorescence quenching. After ALDH2 probe 5 is catalytically oxidized to carboxylate by ALDH2, TICT is inhibited and fluorescence is significantly enhanced. ALDH2 probe 5 enables highly sensitive quantitative imaging of ALDH2 activity in recombinant enzymes, live cells, blood, tissue homogenates, and the brains of living mice. ALDH2 probe 5 can be used for studies related to neuroinflammation .
Target:
Research Areas:
Chondroitinase AC II is a glycosaminoglycan lyase (EC 4.2.2.5) discovered from Arthrobacter sp. CS01. Chondroitinase AC II exhibits broad substrate specificity toward CS-A, CS-C, and HA. Chondroitinase AC II cleaves the β-1,4-glycosidic bond between D-glucuronic acid and N-acetylgalactosamine through a β-elimination mechanism, producing unsaturated disaccharides and thereby degrading chondroitin sulfate and hyaluronic acid. Chondroitinase AC II activity is enhanced by Mn 2+ and inhibited by Zn 2+ and Hg 2+ . Chondroitinase AC II is used for CS oligosaccharide preparation and research related to nerve injury .
Cat. No.: HY-I0201S
CAS No.: 1254771-90-8
Synonyms: P-Fluorophenylboronic acid-d4
Research Areas:
4-Fluorobenzeneboronic acid-d4 (P-Fluorophenylboronic acid-d4) is the deuterated-labeled 4-Fluorobenzeneboronic acid (HY-I0201). 4-Fluorobenzeneboronic acid (P-Fluorophenylboronic acid) is a fluorinated arylboronic acid coupling ligand and precursor. Under the catalysis of heterogeneous palladium nanoparticles, 4-Fluorobenzeneboronic acid participates in the Suzuki-Miyaura C-C coupling reaction to generate fluorinated biphenyl derivatives. 4-Fluorobenzeneboronic acid also participates in the copper-catalyzed three-component reaction with nitrobenzene and potassium metabisulfite as substrates, and finally produces sulfonamides through the formation of arylsulfinate intermediates, copper-assisted S-N bond construction and reduction steps .
Cat. No.: HY-P5352
CAS No.: 299157-43-0
Target:
Research Areas:
Cat. No.: HY-W014118R
CAS No.: 101-86-0
Cat. No.: HY-W087830
CAS No.: 76410-58-7
Synonyms: L-BPA
Cat. No.: HY-W1005067
CAS No.: 2191110-79-7
Research Areas:
EN171 is a covalent 14-3-3σ molecular glue ligand that sequesters neonuclear substrates, including BRD4 and BLC6, into the cytoplasm by recruiting 14-3-3σ. EN171 covalently targets C38 and C96 on 14-3-3 to enhance the interaction between 14-3-3 and ERα, YAP, and TAZ (with EC50 values of 9 μM for human ERα, 45 μM for YAP, and 107 μM for TAZ). EN171 inhibits the transcriptional activity of estrogen receptors and the Hippo pathway in breast cancer cells. EN171 can be used in studies related to breast cancer .
Cat. No.: HY-W243460
CAS No.: 39208-15-6
Target:
Research Areas:
EDTA copper (II) disodium salt, 97% is a negatively charged copper (II)-ethylenediaminetetraacetic acid chelate and also an adsorption substrate. EDTA copper (II) disodium salt, 97% forms amide bonds with chitosan amino groups in weakly acidic (pH 3-5) solutions, while it forms the CuEDTA (OH) 3− hydroxyl complex in strongly alkaline (pH > 12) solutions. EDTA copper (II) disodium salt, 97% can be adsorbed onto granular activated carbon, with electrostatic interactions dominating its pH-dependent adsorption behavior. EDTA copper (II) disodium salt, 97% can be used to eliminate the inhibition of enzyme-catalyzed reactions caused by trace heavy metals .
Cat. No.: HY-Y0531S
CAS No.: 33830-11-4
Synonyms: Tricyclo[3.3.1.1~3,7~]decan-1-ol-d15
Target:
Cat. No.: HY-15560A
CAS No.: 911004-45-0
Cat. No.: HY-112537S1
Purity: ≥98.0%
Cat. No.: HY-113293BS
CAS No.: 2734919-86-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
