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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
216 Results for "
CYP1
" in MedChemExpress (MCE) Product Catalog:
Products (216)
216 Results for "CYP1" in MCE Product Catalog:
1
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Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms [1] .
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Other Monoterpenes Umbelliferae Extract Terpenoids Other Diseases Plants Vernonia Schreb. Disease Research Fields
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ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines [1] .
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CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes [1].
Cat. No.: HY-120377
CAS No.: 1821136-07-5
CYP1A1 inhibitor 8a is a compound that potently and selectively inhibits the CYP1A1 enzyme and has the potential to prevent cancer. CYP1A1 inhibitor 8a exhibits more than 10-fold selectivity for CYP1A1 and more than 100-fold selectivity over other enzymes in the CYP1 subfamily. CYP1A1 inhibitor 8a can effectively antagonize B[a]P-mediated activation of the aryl hydrocarbon receptor (AhR) in yeast cells and protect human cells from CYP1A1-mediated B[a]P toxicity. CYP1A1 inhibitor 8a has the potential to be developed as a cancer chemopreventive agent [1].
Cat. No.: HY-Y0110S1
CAS No.: 78832-54-9
Cat. No.: HY-W007700
CAS No.: 17696-11-6
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8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) [1].
Cat. No.: HY-34464
CAS No.: 136630-39-2
Synonyms: 2,7-DBCZ
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2,7-Dibromocarbazole (2,7-DBCZ) is an orally active AhR agonist and MAOB inhibitor that can cross the blood-brain barrier. 2,7-Dibromocarbazole induces CYP1A/CYP1B1, developmental toxicity and oxidative toxicity, Akt phosphorylation, apoptosis, mitochondrial depolarization, and calcium elevation. 2,7-Dibromocarbazole disrupts dopamine homeostasis, promotes α-synuclein aggregation and transcriptomic dysregulation, leading to hepatic lipid accumulation, liver lesions, brain injury, and angiogenesis/energy metabolism disorders, while activating ERα and inhibiting GRα. 2,7-Dibromocarbazole can be used in research on cardiotoxicity and Parkinson's disease [1] .
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CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC50: 75 nM). CYP1B1-IN-7 also reverses resistance (IC50: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011) [1].
Cat. No.: HY-159006
CAS No.: 65823-65-6
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CYP1B1 ligand 3 (Compound A1) is a selective inhibitor for cytochrome P450 enzyme CYP1B1 with an IC50 of 11.9 nM. CYP1B1 ligand 3 can be utilized for the synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) [1].
Cat. No.: HY-W045990
CAS No.: 582-16-1
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Synonyms: NSC 710305
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Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 [1] .
Cat. No.: HY-N8382
CAS No.: 13164-03-9
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DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
Cat. No.: HY-W015697
CAS No.: 612-58-8
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors [1].
Cat. No.: HY-W275481
CAS No.: 2305-05-7
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γ-Dodecanolactone is a γ-lactone compound. γ-Dodecanolactone exhibits inhibitory activity against CYP1A2 with an IC50 value of 58 µM and a pIC50 value of 4.24. γ-Dodecanolactone can be used in the research of diseases related to the CYP1A2 enzyme [1].
Cat. No.: HY-N1882
CAS No.: 18110-87-7
Category:
Alkaloids Simaroubaceae Extract Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Indole Alkaloids
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Cat. No.: HY-W777979
CAS No.: 38210-27-4
Category:
Polygala fruticosa P.J.Bergius Polygalaceae Extract Coumarins Hydroleaceae Extract Phenylpropanoids Plants
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
