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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
60 Results for "
Melatonin Receptor
" in MedChemExpress (MCE) Product Catalog:
Products (60)
60 Results for "Melatonin Receptor" in MCE Product Catalog:
Synonyms: N-Acetylserotonin-d3; NorMelatonin-d3; O-DemethylMelatonin-d3
Cat. No.: HY-116930
CAS No.: 152302-33-5
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S-20928 is an antagonist for melatonin receptor through inhibition of binding of melatonin to its receptors. S-20928 enhances the 2-Deoxy-D-glucose (2DG) (HY-13966)-induced increase in blood glucose and glucagon levels in rats brain .
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ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively .
Cat. No.: HY-W015169S
CAS No.: 96236-05-4
Synonyms: O-Methylserotonin-d4
Cat. No.: HY-107628
CAS No.: 220339-00-4
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N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses .
Synonyms: N10-Acetyltryptamine; Nb-Acetyltryptamine; Nω-Acetyltryptamine
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N-Acetyltryptamine (N10-Acetyltryptamine) is a mixed agonist-antagonist of the melatonin receptor. N-Acetyltryptamine inhibits acetylserotonin methyltransferase, blocks the conversion of N-acetylserotonin to melatonin, and inhibits neuronal firing activity in suprachiasmatic nucleus neurons. N-Acetyltryptamine is a physiological constituent of mammalian blood. N-Acetyltryptamine is a metabolite of tryptamine in Bacillus cereus .
Cat. No.: HY-P2092
CAS No.: 15136-34-2
Synonyms: Cyclo(Leu-Trp)
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Synonyms: 2-PhenylMelatonin
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UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4 .
Cat. No.: HY-147542
CAS No.: 2411150-76-8
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Melatonin receptor agonist 1 (compound 20c) is a potent melatonin receptor (MT) agonist, with Ki values of 108 nM (MT2) and 1140 nM (MT1) .
Cat. No.: HY-106136
CAS No.: 118702-11-7
Synonyms: PD-6735; LY-156735
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TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .
Cat. No.: HY-159848
CAS No.: 1000334-38-2
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Nedemelteon is a melatonin receptor agonist .
Cat. No.: HY-116046
CAS No.: 170729-12-1
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GR 196429 is a melatonin receptor agonist with some selectivity for the MT1 subtype. GR 196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice .
Cat. No.: HY-107854R
CAS No.: 1210-83-9
Synonyms: N-Acetylserotonin (Standard); NorMelatonin (Standard); O-DemethylMelatonin (Standard)
Cat. No.: HY-101303
CAS No.: 190277-13-5
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5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP .
Cat. No.: HY-100940
CAS No.: 63762-74-3
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6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [ 3H]-melatonin and 2-[ 125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [ 3H]-melatonin binding to MT2 receptors (pKi=9.77) .
Cat. No.: HY-113027R
CAS No.: 1198-84-1
Cat. No.: HY-119010
CAS No.: 753502-19-1
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UCM 549 is a melatonin MT2 receptor inverse agonist and a MT1 receptor antagonist .
Cat. No.: HY-120182
CAS No.: 190328-44-0
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GR 128107 is a competitive melatonin receptor antagonist (pKi: 9.6) .
Cat. No.: HY-169382
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Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate composed of Melatonin (HY-B0075) and Tamoxifen (HY-13757A), which is a potent antagonist of ERα (IC50=863 nM). Melatonin-Tamoxifen Conjugate binds to MLT receptor (Ki=3.1 nM) and promotes β-arrestin (EC50=914 nM) and ERK activation (EC50=98 nM) in cells expressing hMT1 receptor. Melatonin-Tamoxifen Conjugate against several common cell lines MCF-7, MDA-MB-231, and HT-1080 with IC50s of 6.8 μM, 6.4 μM, and 1.7 μM, respectively.
Cat. No.: HY-131947
CAS No.: 343263-95-6
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DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
