332 Results for "

Substrate specificity

" in MedChemExpress (MCE) Product Catalog:
Products (332)

332 Results for "Substrate specificity" in MCE Product Catalog:

3
5-Methyl-2'-deoxycytidine
5-Methyl-2'-deoxycytidine
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3 Cited Publications
Art. -Nr.: HY-W012078
CAS. Nr.: 838-07-3
Synonyms: 5-Methyldeoxycytidine
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

DNA Methyltransferase Endogenous Metabolite

5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .
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2
D-Ala-Lys-AMCA hydrochloride
D-Ala-Lys-AMCA hydrochloride
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2 Cited Publications
Art. -Nr.: HY-111956B
CAS. Nr.: 2703746-41-0
Reinheit:  98.77%
Target:  

Fluorescent Dye

Forschungsgebiete:  

Cancer

D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm) .
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2
Mca-Ala-Pro-Lys(Dnp)-OH
Mca-Ala-Pro-Lys(Dnp)-OH
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2 Cited Publications
Art. -Nr.: HY-P2536
CAS. Nr.: 305336-82-7
Target:  

Angiotensin-converting Enzyme (ACE)

Forschungsgebiete:  

Others

Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .
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2
Ac-VDVAD-AFC TFA
Ac-VDVAD-AFC TFA
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2 Cited Publications
Art. -Nr.: HY-P2615A
Target:  

Fluorescent Dye

Forschungsgebiete:  

Cancer

Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .
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2
Mca-KPLGL-Dap(Dnp)-AR-NH2
Mca-KPLGL-Dap(Dnp)-AR-NH2
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2 Cited Publications
Art. -Nr.: HY-P4931
CAS. Nr.: 720710-69-0
Target:  

MMP

Forschungsgebiete:  

Cancer

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
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2
5-Methyl-2'-deoxycytidine (Standard)
5-Methyl-2'-deoxycytidine (Standard)
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2 Cited Publications
Art. -Nr.: HY-W012078R
CAS. Nr.: 838-07-3
Synonyms: 5-Methyldeoxycytidine (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Reference Standards DNA Methyltransferase Endogenous Metabolite

5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .
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1
Thymine
Thymine
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1 Cited Publications
Art. -Nr.: HY-W010450
CAS. Nr.: 65-71-4
Target:  

Endogenous Metabolite

Forschungsgebiete:  

Metabolic Disease Cancer

Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a Km value of 2.2 μM, Ki of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg .
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1
Gly-Pro-AMC hydrobromide
Gly-Pro-AMC hydrobromide
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1 Cited Publications
Art. -Nr.: HY-137834
CAS. Nr.: 115035-46-6
Reinheit:  98.68%
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .
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1
Kemptide
Kemptide
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1 Cited Publications
Art. -Nr.: HY-P0248
CAS. Nr.: 65189-71-1
Target:  

PKA

Forschungsgebiete:  

Metabolic Disease

Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).
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1
Boc-Ile-Glu-Gly-Arg-AMC
Boc-Ile-Glu-Gly-Arg-AMC
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1 Cited Publications
Art. -Nr.: HY-P2008
CAS. Nr.: 65147-06-0
Synonyms: IEGR-AMC
Target:  

Factor Xa

Forschungsgebiete:  

Cardiovascular Disease

Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
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1
Malantide
Malantide
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1 Cited Publications
Art. -Nr.: HY-P1597
CAS. Nr.: 86555-35-3
Target:  

PKA PKC

Forschungsgebiete:  

Cancer

Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a Km of 16 μM .
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1
Suc-Gly-Pro-AMC
Suc-Gly-Pro-AMC
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1 Cited Publications
Art. -Nr.: HY-145983
CAS. Nr.: 80049-85-0
Reinheit:  99.16%
Target:  

FAP Prolyl Endopeptidase (PREP)

Forschungsgebiete:  

Cancer

Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .
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1
CCP peptide TFA
CCP peptide TFA
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1 Cited Publications
Art. -Nr.: HY-P2171A
Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology

CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
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1
Glabrone
Glabrone
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1 Cited Publications
Art. -Nr.: HY-N4194
CAS. Nr.: 60008-02-8
Category:  

Flavonoids Leguminosae Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones

Target:  

PPAR Influenza Virus

Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .
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1
GW604714X
GW604714X
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1 Cited Publications
Art. -Nr.: HY-138559
CAS. Nr.: 853953-65-8
Reinheit:  98.99%
Target:  

Mitochondrial Metabolism

Forschungsgebiete:  

Neurological Disease

GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC .
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1
H-D-Phe-Pip-Arg-pNA
H-D-Phe-Pip-Arg-pNA
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1 Cited Publications
Art. -Nr.: HY-123275
CAS. Nr.: 64815-81-2
Synonyms: S-2238
Target:  

Thrombin

Forschungsgebiete:  

Others

H-D-Phe-Pip-Arg-pNA (S-2238) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA can be used in biochemical detection-related studies .
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1
H-D-Phe-Pip-Arg-pNA hydrochloride
H-D-Phe-Pip-Arg-pNA hydrochloride
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1 Cited Publications
Art. -Nr.: HY-123275A
CAS. Nr.: 160192-34-7
Reinheit:  99.40%
Synonyms: S-2238 hydrochloride
Target:  

Thrombin

Forschungsgebiete:  

Others

H-D-Phe-Pip-Arg-pNA hydrochloride (S-2238 hydrochloride) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA hydrochloride is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA hydrochloride can be used in biochemical detection-related studies .
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1
H-D-Phe-Pip-Arg-pNA acetate
H-D-Phe-Pip-Arg-pNA acetate
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1 Cited Publications
Art. -Nr.: HY-123275B
CAS. Nr.: 115388-96-0
Reinheit:  98.90%
Synonyms: S-2238 acetate
Target:  

Thrombin

Forschungsgebiete:  

Others

H-D-Phe-Pip-Arg-pNA acetate (S-2238 acetate) is a specific chromogenic peptide substrate for thrombin (Thrombin). The amide bond of H-D-Phe-Pip-Arg-pNA acetate is rapidly hydrolyzed by thrombin, producing a characteristic yellow absorbance at 405 nm, and the change in absorbance is proportional to thrombin activity. H-D-Phe-Pip-Arg-pNA acetate can be used in biochemical detection-related studies .
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1
Poly-L-lysine hydrobromide (MW 4000-15000)
Poly-L-lysine hydrobromide (MW 4000-15000)
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1 Cited Publications
Art. -Nr.: HY-126437H
CAS. Nr.: 25988-63-0
Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery .
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1
PA Janelia Fluor® 549, SE
PA Janelia Fluor® 549, SE
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1 Cited Publications
Art. -Nr.: HY-133536
CAS. Nr.: 1811539-42-0
Reinheit:  98.2%
Synonyms: PA-JF549-NHS
PA Janelia Fluor 549, SE (PA-JF549-NHS) is a bright photoactivatable fluorophore of JF549,SE (JF549,NHS). JF549,SE (JF549,NHS) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor fluorescent dyes can be chemically conjugated to the specific HaloTag substrate (a chloroalkane ligand) to form a fluorescent ligand, rather than binding directly to the HaloTag protein itself.
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