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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
112 Results for "
CTL
" in MedChemExpress (MCE) Product Catalog:
Products (112)
112 Results for "CTL" in MCE Product Catalog:
Cat. No.: HY-172240
CAS No.: 1418305-55-1
Synonyms: TU2218 free base
Research Areas:
Tosposertib (TU2218 free base) is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM). Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer .
Cat. No.: HY-P1907
CAS No.: 151812-18-9
Cat. No.: HY-P990795
Target:
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Cat. No.: HY-P0277
CAS No.: 168635-85-6
Synonyms: CEA peptide
Target:
Proteasome Apoptosis Autophagy Caspase Bcl-2 Family NF-κB PARP
Research Areas:
PI-1840 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC50 value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α .
Cat. No.: HY-P2527
CAS No.: 187671-49-4
Target:
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Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide epitope of the TRP-2 protein that conforms to the MHC class I H2-Kb binding motif. It is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs, induces TRP-2-specific CTL and CD8 + T cell responses, and mediates antibody-dependent antitumor effects against lung metastasis. Tyrosinase-related Protein 2 (TRP-2) (181-188) is used in melanoma research .
Cat. No.: HY-P5470
CAS No.: 152274-91-4
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Cat. No.: HY-P2455
CAS No.: 137856-41-8
Synonyms: Listeriolysin O (91-99)
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CAMK1D-IN-1 (compound I) is an inhibitor of CAMK1D, targeting cytotoxic T lymphocyte (CTL)-resistant tumor cells. CAMK1D impairs CTL-induced death receptor signaling and apoptosis by inhibiting caspases, making it a key and effective target for PD-L1-refractory tumors .
Cat. No.: HY-161982
CAS No.: 3079468-41-7
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JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8 + T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity .
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BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity .
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Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties .
Cat. No.: HY-P1827
CAS No.: 219312-69-3
Target:
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Cat. No.: HY-P1837
CAS No.: 186302-15-8
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Cat. No.: HY-P2495A
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Cat. No.: HY-P5453
CAS No.: 646997-09-3
CFP10 (71–85) is a biological active peptide. (CFP1071–85, that elicited IFN-γ production and CTL activity by both CD4+ and CD8+ T cells from persons expressing multiple MHC class II and class I molecules)
Cat. No.: HY-P3742
CAS No.: 170294-35-6
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Cat. No.: HY-P6355
CAS No.: 198274-43-0
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Cat. No.: HY-P10610A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
