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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
131 Results for "
Genetic
" in MedChemExpress (MCE) Product Catalog:
Products (131)
131 Results for "Genetic" in MCE Product Catalog:
Cat. No.: HY-B1899S
CAS No.: 2044276-15-3
Synonyms: Taurodeoxycholate-d5
Research Areas:
Taurodeoxycholic acid-d5 is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .
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H-L-Lys (4-N3-Z)-OH hydrochloride is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. H-L-Lys (4-N3-Z)-OH hydrochloride enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. H-L-Lys (4-N3-Z)-OH hydrochloride serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions .
Cat. No.: HY-130136A
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TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .
Cat. No.: HY-B0607R
CAS No.: 104206-65-7
Synonyms: NTBC (Standard); Nitisone (Standard); SC0735 (Standard)
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Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
Cat. No.: HY-167710
CAS No.: 941185-83-7
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CRCD2 is a small molecule NT5C2 nucleotidase inhibitor with enhanced 6-mercaptopurine cytotoxic activity. CRCD2 can effectively reverse 6-mercaptopurine resistance caused by mutations in the NT5C2 gene or non-genetic activation mechanisms. CRCD2 combined with 6-mercaptopurine can enhance its cytotoxic activity in NT5C2 wild-type leukemia, showing its potential in the treatment of acute lymphoblastic leukemia .
Cat. No.: HY-400785
CAS No.: 2452300-94-4
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Dapagliflozin impurity A (Compound A) is a dapagliflozin peroxide, a genotoxic impurity, can cause damage to human genetic material at very low concentrations, leading to genetic mutations and possibly tumorigenesis .
Cat. No.: HY-136607
CAS No.: 2231405-65-3
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DiAzK is a bifunctional amino acid. DiAzK can be inserted into almost any protein interface with minimal structural perturbation using genetic code expansion .
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Cat. No.: HY-130136
CAS No.: 2088415-78-3
Target:
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TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .
Cat. No.: HY-111848A
Purity: 99.26%
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PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) .
Cat. No.: HY-111848
CAS No.: 1351169-31-7
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PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) .
Cat. No.: HY-136937
CAS No.: 2067339-51-7
Cat. No.: HY-164977
CAS No.: 3093519-24-2
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JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3
ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders .
Cat. No.: HY-W127628
CAS No.: 58846-77-8
Cat. No.: HY-123359
CAS No.: 414909-09-4
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RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene .
Cat. No.: HY-I0508S
CAS No.: 87976-26-9
Cat. No.: HY-121503
CAS No.: 68207-21-6
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FD44 is a phenothiazine small molecule that inhibits the interaction between neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor Ric8a, a key regulator of synapse number and neurotransmitter release probability. In the Drosophila genetic autism model of fragile X syndrome (FXS), FD44 restored normal synapse number and associative learning .
Cat. No.: HY-P99913
CAS No.: 1384099-30-2
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Cat. No.: HY-10574S
CAS No.: 1312424-26-2
Cat. No.: HY-177757
CAS No.: 1831092-94-4
Research Areas:
NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS2.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS2.1 can be used for the research of genetic diseases caused by nonsense mutations .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
