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Isotope-Labeled Compounds

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Progesterone-13C3

2 Cited Publications

Cat. No.: HY-N0437S2

CAS No.: 327048-87-3

Synonyms: Pregn-4-ene-3,20-dione-¹³C₃

Progesterone- ¹³C₃ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

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L-Tryptophan-13C

2 Cited Publications

Cat. No.: HY-N0623S1

CAS No.: 115709-68-7

Synonyms: Tryptophan-¹³C; Tryptophane-¹³C

L-Tryptophan- ¹³C is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .

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L-Serine-d3

2 Cited Publications

Cat. No.: HY-N0650S8

CAS No.: 105591-10-4

Synonyms: (-)-Serine-d₃; (S)-Serine-d₃

L-Serine-d₃ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

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Terephthalic acid-13C2

2 Cited Publications

Cat. No.: HY-W010098S1

CAS No.: 121191-53-5

Terephthalic acid- ¹³C₂ is the ¹³C-labeled Terephthalic acid. Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models .

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Creatine-d3

2 Cited Publications

Cat. No.: HY-W010388S1

CAS No.: 143827-19-4

Creatine-d₃ is the deuterium labeled Creatine (HY-W010388) . Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain .

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Pyruvic acid-13C3 sodium

2 Cited Publications

Cat. No.: HY-W015913S

CAS No.: 142014-11-7

Synonyms: Sodium 2-oxopropanoate-¹³C₃; Acetylformic acid-¹³C₃ sodium

Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

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Phenylacetylglutamine-d5

2 Cited Publications

Cat. No.: HY-W050026S

CAS No.: 1331909-01-3

Synonyms: NSC 203800-d₅; Phenylacetyl-L-glutamine-d₅

Phenylacetylglutamine-d₅ (NSC 203800-d₅) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .

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Ticagrelor-d7

1 Cited Publications

Cat. No.: HY-10064S

CAS No.: 1265911-55-4

Ticagrelor-d₇ is the deuterium labeled Ticagrelor. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation .

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Navitoclax-d8

1 Cited Publications

Cat. No.: HY-10087S

CAS No.: 1217620-38-6

Purity: 99.71%

Navitoclax-d₈ is the d₈-labeled Navitoclax (HY-10087). Navitoclax (ABT-263 ) is an orally active BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with a K_i value of <1 nM for each target. Navitoclax triggers endogenous Apoptosis and downregulates the expression of Survivin and TGFβ2. Navitoclax alleviates fibrosis and induces thrombocytopenia. Navitoclax exhibits anticancer activity against a variety of tumors and enhances the efficacy of chemotherapy and radiotherapy. Navitoclax can be used in the research of acute lymphoblastic leukemia, ovarian cancer, and fibrotic diseases .

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D-erythro-Sphingosine-d7

1 Cited Publications

Cat. No.: HY-101047S

CAS No.: 1246304-34-6

Purity: 99.00%

Synonyms: Erythrosphingosine-d₇; erythro-C18-Sphingosine-d₇; trans-4-Sphingenine-d₇

D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

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Dasatinib-d8

1 Cited Publications

Cat. No.: HY-10181S

CAS No.: 1132093-70-9

Purity: 98.17%

Synonyms: BMS-354825-d₈

Dasatinib-d₈ (BMS-354825-d₈) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

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Sorafenib-d3

1 Cited Publications

Cat. No.: HY-10201S

CAS No.: 1130115-44-4

Purity: 98.17%

Synonyms: Donafenib; Bay 43-9006-d₃

Sorafenib-d₃ (Donafenib) is the deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .

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Sorafenib-13C,d3

1 Cited Publications

Cat. No.: HY-10201S2

CAS No.: 1210608-86-8

Purity: 98.35%

Synonyms: Bay 43-9006-¹³C,d₃

Sorafenib- ¹³C,d₃ (Bay 43-9006- ¹³C,d₃) is the ¹³C, deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .

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Rapamycin-d3

1 Cited Publications

Cat. No.: HY-10219S

CAS No.: 392711-19-2

Purity: ≥93.0%

Synonyms: Sirolimus-d₃; AY-22989-d₃; NSC 226080-d₃

Rapamycin-d₃ (Sirolimus-d_{3; AY-22989-d3; NSC 226080-d3}) is the deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .

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Monomethyl fumarate-d3

1 Cited Publications

Cat. No.: HY-103252S

CAS No.: 1616345-41-5

Purity: 98.24%

Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

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3-Methoxytyramine-d4 hydrochloride

1 Cited Publications

Cat. No.: HY-103638S

CAS No.: 1216788-76-9

Purity: ≥99.0%

Synonyms: 3-O-methyl Dopamine-d4 hydrochloride

3-Methoxytyramine-d₄ (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1) .

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Linezolid-d3

1 Cited Publications

Cat. No.: HY-10394S

CAS No.: 1127120-38-0

Purity: 99.80%

Synonyms: PNU-100766-d₃

Linezolid-d₃ (PNU-100766-d₃) is a deuterium labeled Linezolid (PNU-100766). Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis .

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L-Kynurenine-d4

1 Cited Publications

Cat. No.: HY-104026S

CAS No.: 2672568-86-2

Purity: 99.40%

L-Kynurenine-d₄ is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2].

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Valproic acid-d4

1 Cited Publications

Cat. No.: HY-10585S

CAS No.: 87745-17-3

Purity: ≥98.0%

Synonyms: VPA-d₄; 2-Propylpentanoic acid-d₄

Valproic acid-d₄ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

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Asoxime-d4 dichloride

1 Cited Publications

Cat. No.: HY-106901AS

Purity: ≥96.0%

Synonyms: HI-6-d₄

Asoxime-d₄ dichloride (HI-6-d₄) is the deuterium labeled Asoxime dichloride. Asoxime dichloride is an orally active thiosemicarbazone-based antidote. Asoxime dichloride is a reversible inhibitor of AChE, and its core mechanism of action is to re-activate AChE inhibited by nerve toxins, thereby restoring the cholinergic nerve function. Asoxime dichloride significantly restores the function of poisoned muscles without reactivating AChE. Asoxime dichloride is an antagonist of acetylcholine receptors (AChRs), including nicotinic receptor and α7 nAChR. Asoxime dichloride can serve as an effective immunomodulator, improving the immune effect of the nervous system.

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