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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1903 Results for "
molecular docking analyses
" in MedChemExpress (MCE) Product Catalog:
Products (1903)
1903 Results for "molecular docking analyses" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: Cyanine3 NHS ester
7
Research Areas:
Eragidomide (CC-90009) is a GSPT1 Molecular Glue degrader. Eragidomide exhibits antiproliferative and pro-apoptotic (apoptosis) activities against acute myeloid leukemia cells. Eragidomide recruits the CRL4CRBN E3 ubiquitin ligase complex to selectively target GSPT1 for ubiquitination and proteasomal degradation. Eragidomide reduces leukemia cell engraftment and eliminates leukemia stem cells. Eragidomide promotes the activation of the GCN1/GCN2/ATF4 pathway and the integrated stress response pathway, inhibits global protein translation, promotes preferential translation of ATF4, and induces the accumulation of ATF4, CHOP and ATF3. The response to Eragidomide is regulated by the ILF2/ILF3 heterodimer complex, the mTOR signaling pathway and the integrated stress response. Eragidomide can be used in research related to acute myeloid leukemia and relapsed/refractory acute myeloid leukemia .
6
6 Cited Publications
Cat. No.: HY-112680
CAS No.: 1417638-60-8
Target:
Research Areas:
Carboxypyridostatin is a G-quadruplex ligand. Carboxypyridostatin has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxypyridostatin reduces cell proliferation and hinders stress granule (SG) formation .
6
6 Cited Publications
Target:
Research Areas:
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation .
6
6 Cited Publications
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .
5
5 Cited Publications
Synonyms: DSS (MW 5000); DXS (MW 5000)
5
5 Cited Publications
Target:
Research Areas:
KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease .
5
5 Cited Publications
Synonyms: 2-Morpholinoethanesulphonic acid
5
5 Cited Publications
Cat. No.: HY-D0858B
CAS No.: 71119-23-8
Synonyms: 2-Morpholinoethanesulphonic acid sodium salt
5
5 Cited Publications
Cat. No.: HY-D0858C
CAS No.: 1266615-59-1
Synonyms: 2-Morpholinoethanesulphonic acid hydrate
5
5 Cited Publications
Cat. No.: HY-D0858E
CAS No.: 39946-25-3
Synonyms: 2-Morpholinoethanesulphonic acid potassium
5
5 Cited Publications
Cat. No.: HY-D0858A
CAS No.: 145224-94-8
Synonyms: 2-Morpholinoethanesulphonic acid monohydrate
5
5 Cited Publications
Synonyms: Deacetylated chitin (MW 150000) (≥85% deacetylated); Poly(D-glucosamine) (MW 150000) (≥85% deacetylated)
Target:
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
5
5 Cited Publications
Cat. No.: HY-D0858D
CAS No.: 117961-21-4
Synonyms: 2-Morpholinoethanesulphonic acid hemisodium
5
5 Cited Publications
Cat. No.: HY-P74743
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MRAP; Fat Cell-Specific Low molecular Weight Protein; Prev. C21orf61; Fat Tissue-Specific Low MW Protein; FALP; Chromosome 21 Open Reading Frame 61; B27; GCCD2; MRAP1; Melanocortin 2 Receptor Accessory Protein; Melanocortin-2 Receptor Accessory Protein
Species:
Human
Source:
HEK293
5
Target:
Research Areas:
5
Target:
Research Areas:
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .
4
4 Cited Publications
Cat. No.: HY-D0155
CAS No.: 288574-78-7
4
4 Cited Publications
Cat. No.: HY-N2025
CAS No.: 57396-78-8
Category:
Flavonoids Flavones Metabolic Disease Plants Bignoniaceae Extract Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields
Target:
4
4 Cited Publications
Cat. No.: HY-K1011A
MCE 3-Color Prestained Protein Marker (10-180 kDa) consists of 10 prestained recombinant proteins with an apparent molecular weight range of 10–180 kDa. This marker enables real-time monitoring of protein migration during SDS-PAGE and facilitates evaluation of protein transfer efficiency. The 250 μL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
