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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1184 Results for "
PH
" in MedChemExpress (MCE) Product Catalog:
Products (1184)
1184 Results for "PH" in MCE Product Catalog:
6
6 Cited Publications
Synonyms: TAK-438 free base
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Research Areas:
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .
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6 Cited Publications
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6 Cited Publications
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5
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Apramycin (Nebramycin II) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic .
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Category:
Microorganisms Antibiotics Animal Husbandry Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer
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5
5 Cited Publications
Synonyms: 2-MorPHolinoethanesulPHonic acid
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5 Cited Publications
Cat. No.: HY-D0858B
CAS No.: 71119-23-8
Synonyms: 2-MorPHolinoethanesulPHonic acid sodium salt
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5 Cited Publications
Cat. No.: HY-D0858C
CAS No.: 1266615-59-1
Synonyms: 2-MorPHolinoethanesulPHonic acid hydrate
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5 Cited Publications
Cat. No.: HY-D0858E
CAS No.: 39946-25-3
Synonyms: 2-MorPHolinoethanesulPHonic acid potassium
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5 Cited Publications
Cat. No.: HY-D0858A
CAS No.: 145224-94-8
Synonyms: 2-MorPHolinoethanesulPHonic acid monohydrate
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5 Cited Publications
Cat. No.: HY-D0858D
CAS No.: 117961-21-4
Synonyms: 2-MorPHolinoethanesulPHonic acid hemisodium
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5
Category:
Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
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4
4 Cited Publications
Synonyms: Alkyne tyramide; Alk-PH
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Research Areas:
Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins . Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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4 Cited Publications
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ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 .
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4 Cited Publications
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Research Areas:
S0859 is a selective, high-affinity generic Na +/HCO3 - transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
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4
4 Cited Publications
Synonyms: CFTR Inhibitor
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
