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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
131 Results for "
exacerbations
" in MedChemExpress (MCE) Product Catalog:
Products (131)
131 Results for "exacerbations" in MCE Product Catalog:
Cat. No.: HY-139621
CAS No.: 2916559-62-9
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Colibactin 742 is a covalently binding DNA-damaging agent targeting DNA, with an IC50 of 5.2 μM against human cervical cancer cells (HeLa). Colibactin 742 covalently binds to DNA, forming interstrand crosslinks (ICLs), activating the Fanconi anemia DNA repair pathway, inducing γH2AX and FANCD2 foci formation and cell cycle arrest, while exacerbating mismatch repair deficiency (MMRd)-related mutations. Colibactin 742 can mimic the genotoxicity of natural Colibactin while avoiding its instability, and is mainly used in colorectal cancer (CRC) related research, including microbial tumorigenesis mechanisms, DNA damage repair pathways, and mutation signature analysis .
Cat. No.: HY-172242
CAS No.: 1887236-33-0
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Verducatib (BI 1291583) is an orally active inhibitor of cathepsin C (also known as DPP1). Verducatib restores the protease-inhibitor balance by inhibiting the activation of neutrophil serine proteases, thereby alleviating pulmonary inflammation and regulating infection responses. Verducatib significantly reduces the risk (including severe exacerbations) and frequency of acute exacerbations in bronchiectasis (BE). Verducatib also improves lung function and quality of life, and shortens the duration of antibiotic use. The overall incidence of adverse events of Verducatib is comparable to that of placebo, with only slightly more mild-to-moderate cutaneous adverse events observed in the high-dose group, demonstrating promising clinical application potential .
Cat. No.: HY-W115752
CAS No.: 10034-93-2
Synonyms: Diamine sulfate (99%)
Cat. No.: HY-P991278
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Cat. No.: HY-19667
CAS No.: 611227-74-8
Synonyms: DPC 333
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BMS-561392 (BMS-561392) is a selective ADAM17(TACE) inhibitor. BMS-561392 inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 can be used in research related to spinal cord injury and inflammatory diseases .
Cat. No.: HY-66011AS
CAS No.: 2596386-23-9
Synonyms: BAY 12-8039-d4 free base
Cat. No.: HY-66011AR
CAS No.: 151096-09-2
Synonyms: BAY 12-8039 free base (Standard)
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Moxifloxacin (Standard) is the analytical standard of Moxifloxacin. This product is intended for research and analytical applications. Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia .
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Thrombin-like enzyme is a proteolytic enzyme extraction of Agkistrodon halys venom. Thrombin-like enzyme can be used for degradation of fibrinogen. Thrombin-like enzyme can exacerbate myosin-induced EAM (experimental autoimmune myositis). Thrombin-like enzyme can be used for degradation of fibrinogen. Thrombin-like enzyme is commonly used for research of acute ischemic cerebrovascular disease, thromboangiitis obliterans, deep phlebitis and sudden deafness .
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Cat. No.: HY-66011AS4
Synonyms: BAY 12-8039-13C,d3
Cat. No.: HY-W747491
CAS No.: 1365620-36-5
Triclosan- 13C12 is 13C labeled Triclosan (HY-B1119). Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
Cat. No.: HY-66011AS2
CAS No.: 2734919-98-1
Synonyms: BAY 12-8039-d3
Cat. No.: HY-116229
CAS No.: 175463-14-6
Synonyms: SB-265805; LB20304
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Gemifloxacin, a fluoroquinolone, is a potent and orally active antipneumococcal agent. Gemifloxacin shows bactericidal activity against highly quinolone-resistant pneumococci.Gemifloxacin can be used for the research of respiratory infections, such as community-acquired pneumonia (CAP) and acute exacerbation of chronic bronchitis (AECB) .
Cat. No.: HY-66011B
CAS No.: 354812-41-2
Synonyms: (Rac)-BAY 12-8039 free base
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(Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is the isoform of Moxifloxacin Hydrochloride (HY-66011), which is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia .
Cat. No.: HY-128740
CAS No.: 31635-99-1
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Mesoxalate (Ketomalonic acid) is an orally active antidiabetic agent. Mesoxalate increases pancreatic insulin content. Mesoxalate reduces dietary hyperglycemia. Mesoxalate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Mesoxalate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Mesoxalate can be used in diabetes-related research .
Cat. No.: HY-W653962
CAS No.: 2726926-25-4
Cat. No.: HY-P10405A
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Cat. No.: HY-P990180
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
