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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
157 Results for "
duration
" in MedChemExpress (MCE) Product Catalog:
Products (157)
157 Results for "duration" in MCE Product Catalog:
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Gallamine Triethiodide (Standard) is the analytical standard of Gallamine Triethiodide. This product is intended for research and analytical applications. Gallamine Gallamine Triethiodide is a blood-brain barrier-permeable skeletal muscle relaxant. Gallamine Triethiodide induces skeletal muscle paralysis by blocking acetylcholine. Gallamine Triethiodide directly stimulates intracardiac β receptors. Gallamine Triethiodide prolongs the duration of afterdischarge in the cat cerebral cortex. Gallamine Triethiodide can be used in studies related to convulsive disorders .
Cat. No.: HY-107719
CAS No.: 81338-23-0
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D-AP7 is a specific NMDA receptor antagonist with inhibitory activity against epileptiform activity. D-AP7 attenuated neuronal activation in spot activity by reducing the duration and number of exogenously induced bursts. D-AP7 also increased the amplitude of secondary action potentials, which may restore neuronal activity in some epileptiform bursts. D-AP7 showed anxiogenic effects and impaired memory consolidation in passive avoidance learning .
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Ambenoxan is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.
Cat. No.: HY-121670A
CAS No.: 1617-99-8
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Ambenoxan hydrochloride is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.
Cat. No.: HY-123525
CAS No.: 550310-04-8
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COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration .
Cat. No.: HY-14743A
CAS No.: 2828433-07-2
Synonyms: SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA
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Golotimod TFA (SCV 07 TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod TFA (SCV 07 TFA) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod TFA (SCV 07 TFA) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
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Hexylcaine (Cyclain) is a local anesthetic. Hexylcaine has the characteristics of fast onset, strong effect, moderate duration, and high safety .
Cat. No.: HY-182537
CAS No.: 119302-18-0
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Org 9616 bromide is a non-depolarizing neuromuscular blocker with a structure similar to Pancuroniam. Org 9616 bromide induces rapid-onset, short-duration neuromuscular blockade .
Cat. No.: HY-W587961
CAS No.: 65733-18-8
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S-Hydroprene is an insecticide. S-Hydroprene prolongs larval and pupa durations, disrupts larval development, suppresses pupation, and exhibits larvicidal activity against Culex quinquefasciatus and Blatta orientalis .
Cat. No.: HY-105881
CAS No.: 14166-26-8
Synonyms: Biglumide; K 2004
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Taglutimide (Biglumide; K 2004) is an orally active hypnotic agent. Taglutimide lowers plasma levels of diphenhydramine in rats and shortens the duration of anesthesia. Taglutimide is used in research on neurological disorders such as sedation and hypnosis .
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Succinylcholine iodide (Suxamethonium iodide) is a depolarizing neuromuscular blocker with rapid onset and short duration of action. Succinylcholine iodide also acts as an agonist of the Acetylcholine receptor. Succinylcholine iodide is used for emergency airway management .
Cat. No.: HY-105656R
CAS No.: 6000-74-4
Synonyms: Hydrocortisone 21-phosphate sodium (Standard); Cortisol 21-phosphate sodium (Standard)
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Hydrocortisone phosphate sodium (Standard) is the analytical standard of Hydrocortisone phosphate sodium (HY-105656). This product is intended for research and analytical applications. Hydrocortisone phosphate sodium is a soft steroid with low anti-inflammatory properties and a short duration of action. Hydrocortisone phosphate sodium can be used for the research for several ocular conditions and gastric ulcers .
Cat. No.: HY-130456
CAS No.: 96436-73-6
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AHR 10718 is an antiarrhythmic agent that suppresses cardiac arrhythmias induced by digitalis intoxication and myocardial infarction in the intact dog. AHR 10718 also depresses membrane responsiveness and conduction, shortens the effective refractory period of specialized conducting fibers less than action potential duration .
Cat. No.: HY-182513
CAS No.: 459842-29-6
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ONO-8539 is an orally active prostanoid EP1 receptor antagonist with competitive, insurmountable binding and slow receptor dissociation for long-duration inhibition. ONO-8539 modulates afferent nerve function related to bladder activity, inhibits detrusor overactivity-related contractions, decreases nonvoiding contractions and voiding duration, and increases uroflow rate with ATP (HY-B2176)-induced detrusor overactivity. ONO-8539 attenuates acid-induced heartburn symptoms, extends time to first heartburn sensation, and prevents primary hypersensitivity after distal esophageal acidification. ONO-8539 can be used for the research of overactive bladder and gastroesophageal reflux disease .
Cat. No.: HY-W650831
CAS No.: 139-94-6
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Nithiazide is an anti-histomonad agent with activity against Histomonas. Nithiazide does not cause macroscopic or histopathological abnormalities in the visceral organs of turkeys and chickens at specified doses and durations. Nithiazide induces tumor formation in multiple organs of rodents. Nithiazide can be used in research related to enterohepatitis and tumors, such as breast tumors, skin fibroadenomas, cystadenomas, liver tumors, etc .
Cat. No.: HY-105439A
CAS No.: 68379-03-3
Synonyms: LY 150378
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Clofilium phosphate (LY 150378) is an antiarrhythmic/antifibrillatory agent. Clofilium phosphate significantly prolongs the action potential duration and effective refractory period of canine cardiac Purkinje fibers, increases the ventricular fibrillation threshold, reduces the risk of reentrant arrhythmias, and enables spontaneous conversion of some ventricular fibrillation episodes to sinus rhythm. Clofilium phosphate is applicable to research related to ventricular fibrillation, arrhythmias, and ventricular tachyarrhythmias .
Cat. No.: HY-180354
CAS No.: 86703-02-8
Synonyms: MDL-899
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Mopidralazine hydrochloride (MDL-899) (Compound 30) is an orally active antihypertensive agent. Mopidralazine hydrochloride significantly reduces systolic blood pressure (ED50 = 1.94 mg/kg) in spontaneously hypertensive rats models. Mopidralazine hydrochloride has a slower onset of action but a longer duration of action and has a significantly smaller effect on increasing heart rate in canine model of renal hypertension. Mopidralazine hydrochloride can be used for the research of hypertension .
Cat. No.: HY-110175R
CAS No.: 191744-13-5
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CX614 (Standard) is the analytical standard of CX614 (HY-110175). This product is intended for research and analytical applications. CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocKing and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression .
Cat. No.: HY-W791041
CAS No.: 116371-66-5
Synonyms: dFdCDP
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Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects .
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Oxophenarsine hydrochloride is an anti-syphilitic agent, and also has non-classical applications including treating chronic discoid lupus erythematosus, inhibiting HIV-1 protein synthesis, and prolonging the duration of insulin action . Oxophenarsine hydrochloride forms an unstable insulin complex via sulfhydryl groups or free amino groups, thereby prolonging the hypoglycemic effect of insulin. Oxophenarsine hydrochloride inhibits HIV-1-specific protein synthesis and virus production .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
