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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
112 Results for "
3CLpro
" in MedChemExpress (MCE) Product Catalog:
Products (112)
112 Results for "3CLpro" in MCE Product Catalog:
7
7 Publications Verification
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Research Areas:
GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively.
5
5 Cited Publications
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ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity .
2
Lufotrelvir (PF-07304814), a phosphate proagent of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.
Cat. No.: HY-172437
CAS No.: 2996148-73-1
Synonyms: S-892216
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Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC50 values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19) [3].
Cat. No.: HY-161177
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Research Areas:
PROTAC KRAS G12D degrader 2 is a peptidomimetic PROTAC specifically targeting the dimeric SARS-CoV-2 3CL Pro protein. PROTAC KRAS G12D degrader 2 inhibits SARS-CoV-2 3CLPro with an IC50 of 21.2 μM. PROTAC KRAS G12D degrader 2 specifically binds to the active site of SARS-CoV-2 3CL Pro. PROTAC KRAS G12D degrader 2 reduces protein levels of SARS-CoV-2 3CL Pro without affecting cell viability. PROTAC KRAS G12D degrader 2 can be used for the study of viral infections in Coronavirus genera .
Cat. No.: HY-N3266
CAS No.: 99353-00-1
Cat. No.: HY-N0063R
CAS No.: 65995-63-3
Target:
Synonyms: WU-04
Iscartrelvir (WU-04) is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. Iscartrelvir has high inhibitory effect on the 3CLpro protein of 6 SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda and Omicron) and 2 coronaviruses (SARS-CoV and MERS-CoV) .
Cat. No.: HY-90001S
CAS No.: 1616968-73-0
Synonyms: ABT 538-d6; RTV-d6
Cat. No.: HY-N8306
CAS No.: 50597-93-8
SARS-CoV-2 3CLpro-IN-13 is a potent SARS-CoV-2 3CL protease inhibitor with an IC50 value of 21 nM. SARS-CoV-2 3CLpro-IN-13 shows anti-coronavirus activity .
Cat. No.: HY-152005
CAS No.: 302821-53-0
SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor of SARS-CoV-2 3CL protease. SARS-CoV-2 3CLpro-IN-6 has potent inhibitory activity for SARS-CoV-2 3CL pro with an IC50 value of 4.9 μM. SARS-CoV-2 3CLpro-IN-6 can be used for the research of coronavirus disease 2019 (COVID-19) .
Cat. No.: HY-152009
CAS No.: 1164478-67-4
SARS-CoV-2 3CLpro-IN-7 is a reversible covalent SARS-CoV-2 3CL protease inhibitor with an IC50 value of 1.4 µM .
Cat. No.: HY-N12677
CAS No.: 199167-23-2
Synonyms: Caflanone; FBL-03G
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Cat. No.: HY-17367S4
CAS No.: 1092540-50-5
Synonyms: BMS-232632-d6
Cat. No.: HY-190319
CAS No.: 3054108-85-6
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Research Areas:
PROTAC SARS-CoV-2 3CLPro degrader 3 is a GC-376-derived peptidomimetic PROTAC degrader of SARS-CoV-2 3CLPro (IC50 = 21.2 μM). PROTAC SARS-CoV-2 3CLPro degrader 3 binds to the active site of dimeric SARS-CoV-2 3CLPro, and its cereblon-binding moiety recruits the cullin-RING ubiquitin ligase complex for polyubiquitination and proteasomal degradation, promoting protease degradation in cultured cells and reducing viral main protease protein levels. PROTAC SARS-CoV-2 3CLPro degrader 3 can be used for research related to SARS-CoV-2 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
