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Results for "

ADAM17/TACE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Bacterial (1) Caspase (2) Fluorescent Dye (2) Interleukin Related (2) mAChR (1) MMP (8) NF-κB (3) p38 MAPK (2) Reference Standards (1) TNF Receptor (7)
By Research Areas:	Cancer (6) Infection (3) Inflammation/Immunology (8) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115670

GW280264X 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks **TACE (ADAM17) and ADAM10 with IC₅₀*s of 8.0 nM and 11.5 nM, respectively . ADAM*10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .

HY-16657

TAPI-1 Maximum Cited Publications 15 Publications Verification	MMP NF-κB Apoptosis TNF Receptor	Inflammation/Immunology Cancer
TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets **ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis**, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .

HY-16657A

(S,S)-TAPI-1	MMP mAChR	Neurological Disease Inflammation/Immunology Cancer
(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a *TACE* (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor .

HY-101448

TMI-1 1 Publications Verification WAY-171318	MMP Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC₅₀ of 8.4 nM), *ADAM-TS-4, ADAM-17* and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

HY-20070

BMS-566394	TNF Receptor	Inflammation/Immunology
BMS-566394 is a selective, orally active *TACE* (ADAM17) inhibitor. BMS-566394 inhibits LPS-induced TNF-α production in whole blood. BMS-566394 selectively inhibits *TACE* activity .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a **TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP** inhibitor and also attenuates TNF-α processing .

HY-19667A

BMS-561392 formate 2 Publications Verification DPC 333 formate	TNF Receptor NF-κB Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology
BMS-561392 formate (DPC 333 formate) is a selective *ADAM17(TACE*) inhibitor. BMS-561392 formate inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 formate also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 formate promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 formate can be used in research related to spinal cord injury and inflammatory diseases .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-19667

BMS-561392 DPC 333	TNF Receptor NF-κB Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology
BMS-561392 (BMS-561392) is a selective *ADAM17(TACE*) inhibitor. BMS-561392 inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 can be used in research related to spinal cord injury and inflammatory diseases .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-101448R

TMI-1 (Standard) WAY-171318 (Standard)	MMP Reference Standards Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (Standard) is the analytical standard of TMI-1 (HY-101448). This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

Cat. No.	Product Name	Target	Research Area

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a **TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP** inhibitor and also attenuates TNF-α processing .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

Recombinant Proteins Recommended:

ADAM17/TACE

Species:	Human (1) Rat (1) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) CHO (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78717

	ADAM17/TACE Protein, Mouse (HEK293, His) ADAM17; TACE; CD156b	Mouse	HEK293
	The ADAM17/TACE protein cleaves TNF-α, releasing it from the membrane and activating various cell surface proteins such as JAM3, ACE2, and the p75 TNF receptor. It also triggers the Notch pathway by cleaving Notch into membrane-associated fragments. ADAM17/TACE Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM17/TACE protein, expressed by HEK293 , with C-His labeled tag.

HY-P72815

	ADAM17/TACE Protein, Rat (HEK293, His) 1 Publications Verification Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; CD156b; TACE	Rat	HEK293
	ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P702499

	ADAM17/TACE Protein, Human (CHO, His) ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; ADAM17; ADAM18; CD156b antigen; CD156b; CSVP; disintegrin and metalloproteinase domain-containing protein 17; EC 3.4.24.86; MGC71942; Snake venom-like protease; TACE; TACEcSVP; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme	Human	CHO
	The ADAM17/TACE protein cleaves TNF-α precursor, releasing its mature soluble form, and mediates the proteolytic release of JAM3 and various cell surface proteins, including p75 TNF receptor, type II IL1 receptor, TGF-α, L-selectin, growth hormone receptor, MUC1, and amyloid precursor protein. ADAM17/TACE Protein, Human (CHO, His) is the recombinant human-derived ADAM17/TACE protein, expressed by CHO , with C-His labeled tag.

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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Rat (1) Mouse (3)
Application:	ICC/IF (3) IP (1) WB (3) FC (3) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P81817

	ADAM17 Antibody (YA1562) CD156b; ADAM17; CSVP; TACE	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	ADAM17 Antibody (YA1562) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAM17.

HY-P84440

	ADAM17 Antibody (YA4137) ADAM17; CSVP; TACE; NISBD; ADAM18; ; NISBD1	WB, ICC/IF, FC, ELISA	Human, Mouse
	ADAM17 Antibody (YA4137) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAM17.

HY-P84440A

	ADAM17 Antibody (YA4137)(PBS only) ADAM17; CSVP; TACE; NISBD; ADAM18; ; NISBD1	WB, ICC/IF, FC, ELISA	Human, Mouse
	ADAM17 Antibody (YA4137) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAM17.

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