Search Result

Results for "

Anti-leukemic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) Akt (5) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (5) Apoptosis (57) Arginase (4) Autophagy (8) Bacterial (11) Bcl-2 Family (9) Bcr-Abl (2) Biochemical Assay Reagents (1) BMI1 (1) c-Myc (7) Calmodulin (1) Casein Kinase (2) Caspase (6) CDK (7) CMV (1) CRM1 (2) Cytochrome P450 (1) Deubiquitinase (3) Dihydroorotate Dehydrogenase (1) Discoidin Domain Receptor (1) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (1) DNA/RNA Synthesis (29) Dopamine Receptor (5) Drug Intermediate (1) DYRK (2) Endogenous Metabolite (21) Environmental Pollutants (2) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) Fat Mass and Obesity-associated Protein (FTO) (1) Flavivirus (1) FLT3 (7) Fluorescent Dye (1) Fungal (8) HDAC (5) Histone Demethylase (1) Histone Methyltransferase (9) HSV (1) Interleukin Related (3) IRAK (1) Isotope-Labeled Compounds (14) JAK (5) LAG-3 (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) MNK (1) mTOR (2) Myosin (1) Necroptosis (1) Nucleoside Antimetabolite/Analog (7) Orthopoxvirus (2) p38 MAPK (1) PANoptosis (1) Parasite (2) PARP (4) Phosphodiesterase (PDE) (1) PI3K (6) PROTACs (2) Pyroptosis (2) Reactive Oxygen Species (ROS) (2) Reference Standards (9) RSV (1) RUNX (2) Ser/Thr Kinase (1) SHMT (1) Src (1) STAT (9) Survivin (1) TGF-beta/Smad (2) TGF-β Receptor (2) Topoisomerase (5) Transmembrane Glycoprotein (1) VZV (1)
By Research Areas:	Cancer (125) Cardiovascular Disease (5) Endocrinology (5) Infection (24) Inflammation/Immunology (25) Metabolic Disease (15) Neurological Disease (12)
Oligonucleotides:	Nucleotide Analogs (1) Solubilizing Agents (1) Freeze-drying Protective Agents (1) Antisense Oligonucleotides (1) Adenine Nucleotide (1)

136

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13677

6-Mercaptopurine Maximum Cited Publications 17 Publications Verification Mercaptopurine; 6-MP	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-N0667

L-Asparagine 5 Publications Verification (-)-Asparagine; Asn; Asparamide	Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-17381

Idarubicin hydrochloride Maximum Cited Publications 17 Publications Verification 4-Demethoxydaunorubicin hydrochloride	Topoisomerase Bacterial Fungal Autophagy Antibiotic DNA/RNA Synthesis c-Myc	Infection Cancer
Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.

HY-153274

CWI1-2 4 Publications Verification	Apoptosis	Cancer
CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-112885B

nor-NOHA monoacetate 5 Publications Verification Nω-Hydroxy-nor-L-arginine monoacetate	Arginase Apoptosis	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA monoacetate is a selective and reversible arginase inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-P99412

Lusvertikimab 1 Publications Verification OSE-127	Interleukin Related	Cancer
Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research .

HY-100423

Eltanexor 3 Publications Verification KPT-8602	CRM1	Cancer
Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC₅₀=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines .

HY-B1516

Alovudine 3 Publications Verification 3'-Fluoro-3'-deoxythymidine; 3′-Deoxy-3′-fluorothymidine; FLT	DNA/RNA Synthesis Orthopoxvirus	Infection Cancer
Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than ¹⁸F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity .

HY-123954

BTX-A51 1 Publications Verification Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-112885A

nor-NOHA acetate 5 Publications Verification Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate is a selective and reversible Arginase inhibitor. nor-NOHA acetate induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism .

HY-112885C

nor-NOHA dihydrochloride 5 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible Arginase inhibitor. nor-NOHA dihydrochloride induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride improves liver ischemia-reperfusion injury. nor-NOHA dihydrochloride can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism .

HY-109117

Iadademstat 5+ Cited Publications ORY-1001	Histone Demethylase Apoptosis	Cancer
Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research .

HY-112041

Unesbulin 3 Publications Verification PTC596	BMI1 Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-N0667S2

L-Asparagine-15N2 monohydrate 1 Publications Verification (-)-Asparagine-15N2 monohydrate; Asn-15N2 monohydrate; Asparamide-15N2 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine- ¹⁵N₂ monohydrate is the ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-13677A

6-Mercaptopurine hydrate Maximum Cited Publications 17 Publications Verification Mercaptopurine hydrate; 6-MP hydrate	Nucleoside Antimetabolite/Analog	Cancer
6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-W017443

L-Asparagine monohydrate 5 Publications Verification	Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
L-Asparagine monohydrate is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-153274A

CWI1-2 hydrochloride 4 Publications Verification	Apoptosis	Cancer
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-141429A

AS-99 TFA 2 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 μM, K_d= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-B1336

Furazolidone 3 Publications Verification	Environmental Pollutants Antibiotic Bacterial Apoptosis Parasite	Infection Cancer
Furazolidone is a monoamine oxidase (MAO) inhibitor with antiproliferative, apoptosis-inducing and differentiation-promoting activities. Furazolidone may inhibit leukemia fusion protein-mediated bone marrow transformation by upregulating the stability of the tumor suppressor protein p53. Furazolidone exhibits anti-leukemic activity in acute myeloid leukemia (AML) cell lines and can be used for anti-AML research [2].

HY-N0838

Cephalotaxine 1 Publications Verification (-)-Cephalotaxine; ZINC19795976	Flavivirus	Infection Cancer
Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity .

HY-102048

STAT5-IN-2 2 Publications Verification	STAT Apoptosis	Cancer
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect .

HY-112885

nor-NOHA Nω-Hydroxy-nor-L-arginine	Apoptosis Arginase	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-151411

RUNX1/ETO tetramerization-IN-1	RUNX	Cancer
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO (EC₅₀=0.25 μM), restores gene expression down-regulated by RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO-depending SKNO-1 cells, and reduces the RUNX1/ETO-related tumor growth in a mouse model .

HY-169091

TS-002266	DNA/RNA Synthesis	Cancer
TS-002266 is a small molecule TUT4/7 inhibitor with anti-leukemic effects. TS-002266 is promising for research of cancers .

HY-123955

Casein Kinase inhibitor A86	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-109179

Itacnosertib TP-0184	JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor	Cancer
Itacnosertib (TP-0184) is the inhibitor for FLT3, ACVR1 (ALK2, IC₅₀=8 nM) and JAK2 (IC₅₀=8540 nM). Itacnosertib exhibits anti-leukemic activity .

HY-N0667S5

L-Asparagine-d3 hydrate 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine-d₃ hydrate is the deuterium labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N8146

Bruceantinol	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK	Infection Cancer
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

HY-149334

ZLD115	Fat Mass and Obesity-associated Protein (FTO)	Metabolic Disease
ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines .

HY-134333

ICCB280	Apoptosis	Cancer
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc) .

HY-141430

AS-85	Histone Methyltransferase	Cancer
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC₅₀=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K_d value of 0.78 μM .

HY-178500

WCY-8-67	Deubiquitinase Apoptosis STAT JAK Akt PI3K	Cancer
WCY-8-67 is an orally active and selective USP5 inhibitor, with an IC₅₀ value of 1.33 μM. WCY-8-67 induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways in vitro. WCY-8-67 inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 can be used for the study of acute myeloid leukemia .

HY-N0667R

L-Asparagine (Standard) (-)-Asparagine (Standard); Asn (Standard); Asparamide (Standard)	Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine (Standard) is the analytical standard of L-Asparagine (HY-N0667). This product is intended for research and analytical applications. L-Asparagine is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
L-Asparagine- ¹³C₄, ¹⁵N₂ monohydrateis the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-123523

Enocitabine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis CMV	Infection Cancer
Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities .

HY-109179A

Itacnosertib hydrochloride TP-0184 hydrochloride	JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor	Cancer
Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC₅₀=8 nM) and JAK2 (IC₅₀=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity .

HY-141429

AS-99 free base 2 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-120997

E6 Berbamine Berbamine p-nitrobenzoate	Calmodulin Myosin Phosphodiesterase (PDE)	Cardiovascular Disease Cancer
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia .

HY-150109A

Purinostat	HDAC	Cancer
Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate (HY-150109), the mesylate salt of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for leukemic stem cell (LSC) survival, including c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSC by increasing GLS1 .

HY-174367

RUNX1/ETO-IN-1	RUNX Apoptosis	Cancer
RUNX1/ETO-IN-1 is a RUNX1-ETO oncogenic fusion protein inhibitor that specifically targets the NHR2 oligomerization domain. RUNX1/ETO-IN-1 directly interacts with the NHR2 (K_D,app = 39 μM). RUNX1/ETO-IN-1 exhibits anti-leukemic activity by inducing apoptosis and promoting differentiation in RUNX1/ETO-translocated AML cells. RUNX1/ETO-IN-1 remains essentially uncharged at physiological pH, demonstrating superior membrane permeability.

HY-133900

Deoxyharringtonine	Others	Cancer
Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity .

HY-N0667S3

L-Asparagine-13C4 monohydrate (-)-Asparagine-13C4 monohydrate; Asn-13C4 monohydrate; Asparamide-13C4 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine- ¹³C₄ monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-157327

AKE-72	Bcr-Abl	Cancer
AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABL ^WT, BCR-ABL ^T315, BCR-ABL ^E255K, BCR-ABL ^F3171, BCR-ABL ^H396P and BCR-ABL ^Q252H with IC₅₀s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line .

HY-178500A

WCY-8-67 TFA	Deubiquitinase Apoptosis STAT JAK Akt PI3K	Cancer
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC₅₀ value of 1.33 μM. WCY-8-67 TFA induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways. WCY-8-67 TFA inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 TFA demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 TFA can be used for the study of acute myeloid leukemia .

HY-U00095

Hepsulfam 2 Publications Verification NCI 329680; ZINC01574758	DNA Alkylator/Crosslinker	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC₅₀ of 0.91 μg/mL in a panel of different tumors.

HY-111008A

Trimidox hydrochloride VF-233 hydrochloride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-13677S

6-Mercaptopurine-d2 Mercaptopurine-d₂; 6-MP-d₂	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine-d₂ is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent .

HY-163803

CM-444	HDAC DNA Methyltransferase	Cancer
CM-444 is inhibitor for HDAC (IC₅₀ is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC₅₀ is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models .

HY-N17612

Haplophytin-A	Apoptosis Caspase Bcl-2 Family	Cancer
Haplophytin-A is a quinoline alkaloid. Haplophytin-A is a potent apoptosis inducer that exerts robust anti-leukemic activity by activating the caspase-8-dependent apoptotic pathway. Haplophytin-A can be used for the research of promyelocytic leukemia .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99412

Lusvertikimab 1 Publications Verification OSE-127	Interleukin Related	Cancer
Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research .

HY-P99027

Ieramilimab LAG525; IMP701; Hu5A8	LAG-3	Cancer
Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .

HY-P991641

IMC-EB10 LY3012218	FLT3 p38 MAPK STAT PI3K Akt	Cancer
IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity (K_d = 158 pM) and blocks the binding of FLT3 ligand to FLT3 (IC₅₀ ≈ 10 nM), thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research .

HY-P992058

Leukotuximab ART-140; DNP-001; EGX-040	Transmembrane Glycoprotein	Cancer
Leukotuximab (ART-140; EGX-040) is an anti-JL1 mAb and an anti-leukemic agent. Leukotuximab targets the JL1 epitope of CD43 and exerts cytotoxic effects on JL1-positive leukemia cells. Except for thymocytes and some bone marrow mononuclear cells, Leukotuximab causes no damage to most normal tissues. Leukotuximab can be used in the research of acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13677

6-Mercaptopurine Maximum Cited Publications 17 Publications Verification Mercaptopurine; 6-MP	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-N0667

L-Asparagine 5 Publications Verification (-)-Asparagine; Asn; Asparamide	Neurological Disease Classification of Application Fields Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-P2970

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning .

HY-135190

(-)-Cedrene 2 Publications Verification α-cedrene	Infection Structural Classification Cedrus deodara (Roxburgh) G. Don Classification of Application Fields Pinaceae Terpenoids Sesquiterpenes Metabolic Disease Plants Disease Research Fields Source Classification	Environmental Pollutants Bacterial
(-)-Cedrene (α-cedrene) is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC₅₀ = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC₅₀ = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity .

HY-W017443

L-Asparagine monohydrate 5 Publications Verification	Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine monohydrate is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0838

Cephalotaxine 1 Publications Verification (-)-Cephalotaxine; ZINC19795976	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Taxaceae Plants Cephalotaxaceae Disease Research Fields Taxus chinensis (Pilger) Rehd. Cephalotaxus fortunei Hooker Source Classification Cancer	Flavivirus
Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity .

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-N0667R

L-Asparagine (Standard) (-)-Asparagine (Standard); Asn (Standard); Asparamide (Standard)	Structural Classification Immune System Disorder Microorganisms Disease markers Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer Source Classification	Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine (Standard) is the analytical standard of L-Asparagine (HY-N0667). This product is intended for research and analytical applications. L-Asparagine is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-122295

Dehydroleucodine	other families Artemisia douglasiana Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N17612

Haplophytin-A	Structural Classification Alkaloids Other Alkaloids Rutaceae Plants Haplophyllum acutifolium (DC.) G. Don Source Classification	Apoptosis Caspase Bcl-2 Family
Haplophytin-A is a quinoline alkaloid. Haplophytin-A is a potent apoptosis inducer that exerts robust anti-leukemic activity by activating the caspase-8-dependent apoptotic pathway. Haplophytin-A can be used for the research of promyelocytic leukemia .

HY-W017443R

L-Asparagine monohydrate (Standard)	Structural Classification Amino acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-13677R

6-Mercaptopurine (Standard) Mercaptopurine (Standard); 6-MP (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite
6-Mercaptopurine (Standard) is the analytical standard of 6-Mercaptopurine. This product is intended for research and analytical applications. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-N8402

Germacrone 4,5-epoxide	Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Source Classification Zingiberaceae	Others
Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities .

HY-N14155

Epelmycin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Fungal
Epelmycin A has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14157

Epelmycin C	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Fungal
Epelmycin C has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14159

Epelmycin E	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Fungal
Epelmycin E has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14158

Epelmycin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Fungal
Epelmycin D has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N10071

Poricoic acid G	Microorganisms Ketones, Aldehydes, Acids Source Classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-N3401

Lasiodiplodin	Natural Products Microorganisms Source Classification	Others
Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .

HY-N7549

Dehydrobruceantin	Triterpenes Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Plants Source Classification	Others
Dehydrobruceantin has potential antileukemic activity .

HY-N3171A

(+)-Nortrachelogenin Wikstromol	Natural Products Classification of Application Fields Thymelaeaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Wikstroemia indica Cancer	Apoptosis PI3K
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

HY-135771

Avarone (+)-Avarone	Quinones Structural Classification Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Source Classification	Others
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

HY-125067

Yadanzioside P	Simaroubaceae Plants Saccharides Monosaccharides Source Classification Brucea javanica (L.) Merr.	Others
Yadanzioside P is an *antileukemic* quassinoid glycoside. Yadanzioside P can be isolated from the seeds of Brucea javanica (L.). Yadanzioside P can be used for the research of cancer .

HY-N14180

6-Deoxyilludin M	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

HY-N12641

Ardisianone	Quinones Benzene Quinones Plants Primulaceae Source Classification	Apoptosis Pyroptosis
Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML) .

HY-135190R

(-)-Cedrene (Standard) α-cedrene (Standard)	Structural Classification Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Plants Source Classification	Bacterial Reference Standards
(-)-Cedrene (α-cedrene) (Standard) is the analytical standard of (-)-Cedrene. This product is intended for research and analytical applications. (-)-Cedrene is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC₅₀ = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC₅₀ = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity .

HY-N9826

Icterogenin	Structural Classification Terpenoids Verbenaceae Plants Pentacyclic Triterpenoids Lantana camaraLinn. Source Classification	Bcl-2 Family
Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development .

HY-124900

Tylophorinicine	Apocynaceae Structural Classification Alkaloids Piperidine Alkaloids Plants Tylophora ovata (Lindl.) Hook. ex Steud. Source Classification	Fungal
Tylophorinicine is an anti-leukemic and anti-fungal agent. Tylophorinicine exhibits minimum inhibitory concentrations (MIC) in the range of 2-4 mg/mL for TdnH and 0.6-2.5 mg/mL for TnnH against Candida species. Tylophorinicine is a phenanthroindolizidine alkaloid from tylophora asthamatica and pergulatia pallid. Tylophorinicine inhibits thymidylate synthase by pergularinine .

HY-N9784

2′′,3′′-Dihydroochnaflavone	Structural Classification Haplopteris anguste-elongata (Hayata) E. H. Crane Flavonoids Phenols Polyphenols Plants Pteris vittata L. Biflavones Source Classification	Others
2′′,3′′-Dihydroochnaflavone is a flavonoid/flavanone-type ether-linked biflavonoid anti-leukemic compound. 2′′,3′′-Dihydroochnaflavone exhibits significant cytotoxicity against P388 murine lymphocytic leukemia cells (IC₅₀ = 3.1 μg/mL). It can be naturally extracted from the dried leaves of Quintinia acutifolia and has also been previously isolated and identified from Ochna interrima and Luxemburgia nobilis (both Ochnaceae plants). 2′′,3′′-Dihydroochnaflavone can be used in research related to anti-tumor (especially leukemia) applications .

HY-N18237

Bruceanol A	Triterpenes Structural Classification Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Plants Source Classification	Others
Bruceanol A is an antileukemic quassinoid glycoside isolated from Brucea javanica. Bruceanol A exhibits antileukemic activity against P-388 lymphocytic leukemia in vivo. Bruceanol A can be used in studies related to P-388 lymphocytic leukemia .

HY-126205

Deacetyleupaserrin	Eupatorium semiserratum DC. Terpenoids Sesquiterpenes Asteraceae Plants Source Classification	Others
Deacetyleupaserrin is a sesquiterpenoid with antileukemic activity that can be isolated from Eupatorium semiserratum .

HY-N7153

10-Hydroxycanthin-6-one	Alkaloids Monophenols Simaroubaceae Classification of Application Fields Phenols Pyridine Alkaloids Plants Disease Research Fields Indole Alkaloids Brucea javanica (L.) Merr. Source Classification Cancer	Others
10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent .

Cat. No.	Product Name	Chemical Structure

HY-N0667S2

L-Asparagine-15N2 monohydrate

1 Publications Verification

L-Asparagine- ¹⁵N₂ monohydrate is the ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S5

L-Asparagine-d3 hydrate

1 Publications Verification

L-Asparagine-d₃ hydrate is the deuterium labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate

L-Asparagine- ¹³C₄, ¹⁵N₂ monohydrateis the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-13677S1

6-Mercaptopurine-13C2,15N
6-Mercaptopurine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-N0667S3

L-Asparagine-13C4 monohydrate

L-Asparagine- ¹³C₄ monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-13677S

6-Mercaptopurine-d2
6-Mercaptopurine-d₂ is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent .

HY-W017443S1

L-Asparagine-amide-15N monohydrate

L-Asparagine-amide- ¹⁵N monohydrate is the ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S7

L-Asparagine-13C4,15N2

L-Asparagine- ¹³C₄, ¹⁵N₂ ((-)-Asparagine- ¹³C₄, ¹⁵N₂) is the ¹³C and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W740364

3'-Deoxy-3'-fluorothymidine-d3
3'-Deoxy-3'-fluorothymidine-d₃ is the deuterium labeled Alovudine (HY-B1516). Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity .

HY-N0667S1

L-Asparagine-15N2,d8

L-Asparagine- ¹⁵N₂,d₈ is the ¹⁵N- and deuterium labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S4

L-Asparagine-4-13C monohydrate

L-Asparagine-4- ¹³C monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S4

L-Asparagine-1,2,3,4-13C4 monohydrate

L-Asparagine-1,2,3,4- ¹³C₄ monohydrate is the ¹³C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S

L-Asparagine-13C4,15N2,d8

L-Asparagine- ¹³C₄, ¹⁵N₂,d₈ is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S2

L-Asparagine-13C4,15N2,d3 monohydrate

L-Asparagine- ¹³C₄, ¹⁵N₂,d₃ monohydrate is the deuterium, ¹³C-, and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S3

L-Asparagine-15N2,d3 monohydrate

L-Asparagine- ¹⁵N₂,d₃ monohydrate is the deuterium and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

Cat. No.	Product Name		Classification

HY-N0667

L-Asparagine 5 Publications Verification (-)-Asparagine; Asn; Asparamide		Freeze-drying Protective Agents Solubilizing Agents
L-Asparagine is an essential amino acid for *leukemic* cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-173189A

2-5A pentasodium solution (100 mM) 2′,5′-ApApA pentasodium; 2′,5′-trioligoadenylate pentasodium; 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine pentasodium		Nucleotide Analogs Adenine Nucleotide
2-5A (2′,5′-ApApA) pentasodium solution 100 mM is a high-affinity (K_a=0.04 nM) RNase L binder. 2-5A pentasodium solution 100 mM activates the nuclease activity of latent RNase L to cleave single-stranded RNA by inducing conformational changes and dimerization of latent RNase L, thereby mediating critical antiviral responses and enhancing interferon effects. 2-5A pentasodium solution 100 mM not only effectively inhibits Rauscher murine leukemia virus replication, reduces viremia and splenomegaly, but also enhances antileukemic efficacy when combined with amphotericin B and exhibits favorable high-dose tolerance. 2-5A pentasodium solution 100 mM is an important tool molecule for investigating the pathological mechanisms of viral infection, hereditary prostate cancer and leukemia .

HY-153495

Prexigebersen BP1001		Antisense Oligonucleotides
Prexigebersen (BP1001) is an antisense oligonucleotide targeting Bcl-2 and Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Anti-leukemic

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products