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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

C4 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Aldose Reductase (3) Amylases (1) Androgen Receptor (3) Antibiotic (3) Antibody-Drug Conjugates (ADCs) (1) Antifolate (3) Apoptosis (12) Autophagy (2) Bacterial (5) Biochemical Assay Reagents (3) Calcium Channel (3) Calmodulin (1) Caspase (1) CDK (1) Complement System (1) Dihydrofolate reductase (DHFR) (3) DNA/RNA Synthesis (10) Drug-Linker Conjugates for ADC (1) E3 Ligase Ligand-Linker Conjugates (7) Endogenous Metabolite (17) Environmental Pollutants (1) Epigenetic Reader Domain (3) GLUT (1) Glycosidase (1) HDAC (1) HSP (2) Isotope-Labeled Compounds (20) JNK (1) Keap1-Nrf2 (1) Leukotriene Receptor (4) Liposome (1) mTOR (1) NF-κB (2) NO Synthase (2) P-glycoprotein (1) p38 MAPK (3) Parasite (3) PARP (1) PERK (1) Pregnane X Receptor (PXR) (1) PROTACs (3) RAR/RXR (1) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Survivin (2) Thrombopoietin Receptor (1)
By Research Areas:	Cancer (43) Cardiovascular Disease (3) Endocrinology (1) Infection (6) Inflammation/Immunology (15) Metabolic Disease (10) Neurological Disease (7)
Oligonucleotides:	Cationic Lipids (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10373

Trimetrexate 2 Publications Verification CI-898	Dihydrofolate reductase (DHFR) Antibiotic Antifolate Parasite Bacterial DNA/RNA Synthesis	Infection Cancer
Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC₅₀ values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer .

HY-N2908

Atraric acid Methyl atrarate	Environmental Pollutants NF-κB Androgen Receptor p38 MAPK NO Synthase	Inflammation/Immunology Cancer
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases .

HY-N0682S3

Pyridoxine-13C4 hydrochloride Pyridoxol-13C4 hydrochloride; Vitamin B6-13C4 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-113446

Leukotriene C4	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-135336A

(S)-Verapamil hydrochloride (S)-(-)-Verapamil hydrochloride	P-glycoprotein Leukotriene Receptor Calcium Channel Apoptosis	Cancer
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-112914

mTOR inhibitor-1 3 Publications Verification	mTOR Autophagy	Cancer
mTOR inhibitor-1 (Compound C-4) is an ATP-Competitive mTOR inhibitor which can suppress cells proliferation and inducing autophagy .

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-107609

BAY-u 9773	Leukotriene Receptor	Inflammation/Immunology Endocrinology
BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis .

HY-150644

S07-2010 1 Publications Verification	Aldose Reductase	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, *AKR1C4, AKR1C1* and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

HY-W750796

Butyric acid-13C4 sodium Butanoic acid-13C4 sodium	Isotope-Labeled Compounds Endogenous Metabolite
Butyric acid-13C4 sodium (Butanoic acid-13C4 sodium) is a stable isotope labeled compound with the activity of promoting cell proliferation and regulating gene expression. Butyric acid-13C4 sodium can be used in metabolic research and compound development to help scientists gain a deeper understanding of the role of short-chain fatty acids in organisms. Butyric acid-13C4 sodium also plays an important role in nutrition and intestinal health research, especially in the regulation of probiotic function and intestinal microbiota.

HY-D0844S

Glutathione oxidized-13C4,15N2 1 Publications Verification L-Glutathione oxidized-¹³C₄,¹⁵N₂; GSSG-¹³C₄,¹⁵N₂; Oxiglutatione-¹³C₄,¹⁵N₂	Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Endogenous Metabolite	Metabolic Disease
Glutathione oxidized- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .

HY-122678

LQZ-7F	Survivin Apoptosis	Cancer
LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC₅₀s of 2.99 and 2.47 µM, respectively .

HY-103606

(S,R,S)-AHPC-PEG6-C4-Cl VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-103605

(S,R,S)-AHPC-C6-PEG3-C4-Cl 1 Publications Verification VH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl) is a conjugate of ligands for E3 and 20-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-C6-PEG3-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-W016498S1

Paraxanthine-13C4,15N3	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
Paraxanthine- ¹³C₄, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-Y0836S

Diethyl succinate-13C4 1,4-Diethyl butanedioate-1,2,3,4-¹³C₄	Isotope-Labeled Compounds	Metabolic Disease
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate . Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring .

HY-N0830S

Palmitic acid-1,2,3,4-13C4	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-168905

SGC-CAMKK2-1	Calmodulin	Cancer
SGC-CAMKK2-1, a chemical probe, is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC₅₀ of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC₅₀ of 1.6 μM .

HY-P99719

Lupartumab Amadotin BAY 1129980; Anti-C4.4a antibody-drug conjugates	Antibody-Drug Conjugates (ADCs)	Cancer
Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human *C4.4A* (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer .

HY-160852

YSK 12C4	Liposome	Inflammation/Immunology
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .

HY-115446A

Lenalidomide-C4-NH2 hydrochloride Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC₅₀s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively .

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
L-Asparagine- ¹³C₄, ¹⁵N₂ monohydrateis the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-147281

BAY 1135626	Drug-Linker Conjugates for ADC	Cancer
BAY 1135626 is used to synthesize BAY 1129980, and use to anti-tumor research. BAY 1129980 is a Auristatin-based anti-C4.4A (LYPD3) antibody–agent conjugate (ADC), is used to non–small cell lung cancer (NSCLC) research .

HY-132991

ML 2-14 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
ML 2-14 is a PROTAC targeting BRD4 with a C4 alkyl linker. ML 2-14 consists of the E3 ligase ligand EN219 (HY-115715) (bule part), the target protein ligand JQ-1 (HY-13030) (red part), and the PROTAC linker (balck part). ML 2-14 can effectively degrade BRD4 in 231MFP breast cancer cells, and this effect can be reversed by the proteasome inhibitor Bortezomib (HY-10227) and the E1 activase inhibitor TAK-243 (HY-100487) .

HY-103607

(S,R,S)-AHPC-PEG2-C4-Cl 1 Publications Verification VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-N0667S3

L-Asparagine-13C4 monohydrate (-)-Asparagine-13C4 monohydrate; Asn-13C4 monohydrate; Asparamide-13C4 monohydrate	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine- ¹³C₄ monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W127393

N-Nonanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

HY-P991229

MK-4721 AGS-1C4D4; AGS-PSCA	Complement System	Cancer
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a K_a value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .

HY-15306S

Eltrombopag-13C4 1 Publications Verification SB-497115-¹³C₄	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-124585

Y08060	Epigenetic Reader Domain	Cancer
Y08060 is a selective BET inhibitor. Y08060 inhibits the viability of C4-2B and LNCaP cell lines with IC₅₀ values of 3.23 and 4.41 μM. Y08060 can suppress colony formation as well as AR expression in prostate cancer cell line. Y08060 can be studied in prostate cancer research .

HY-175017

Survivin-IN-2	Survivin	Cancer
Survivin-IN-2 is a survivin inhibitor. Survivin-IN-2 shows cytotoxicity in cells with IC₅₀s of 0.53 μM (C4-2 cells) and 1.06 μM (PC-3 cells). Survivin-IN-2 effectively suppresses xenograft tumor growth without apparent toxicity and eliminates survivin in the tumors. Survivin-IN-2 can be used for the study of prostate cancer .

HY-130429

14,15-Leukotriene C4 Eoxin C4	Endogenous Metabolite	Inflammation/Immunology
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases .

HY-10373A

Trimetrexate trihydrochloride CI-898 trihydrochloride	Dihydrofolate reductase (DHFR) Antibiotic Antifolate Parasite Bacterial DNA/RNA Synthesis	Infection Cancer
Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC₅₀ values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer .

HY-N0667S7

L-Asparagine-13C4,15N2 (-)-Asparagine-¹³C₄,¹⁵N₂; Asn-¹³C₄,¹⁵N₂; Asparamide-¹³C₄,¹⁵N₂	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine- ¹³C₄, ¹⁵N₂ ((-)-Asparagine- ¹³C₄, ¹⁵N₂) is the ¹³C and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-135336AS

(S)-Verapamil-d7 hydrochloride (S)-(-)-Verapamil D7 hydrochloride	Isotope-Labeled Compounds Leukotriene Receptor Calcium Channel Apoptosis	Cancer
(S)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-142772

Y08284	Epigenetic Reader Domain	Cancer
Y08284 is a potent, selective, oral active CBP bromodomain inhibitor with an IC50 of 4.21 nM. Y08284 suppresses the proliferation of prostate cancer cell lines LNCaP, C4-2B, and 22Rv1. Antitumor activity .

HY-P2969

Complement factor I	Endogenous Metabolite	Metabolic Disease
Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .

HY-121588

IMTPPE	Adrenergic Receptor	Cancer
IMTPPE is an inhibitor of the androgen receptor (AR) in C4-2 prostate cancer cells, inhibiting its transcriptional activity and protein levels. IMTPPE inhibited the proliferation of AR-positive prostate cancer cells but had no effect on AR-negative prostate cancer cells. IMTPPE also inhibited the growth of enzalutamide-resistant 22Rv1 xenograft tumors .

HY-135336AS1

(S)-Verapamil hydrochloride-d6 (S)-(-)-Verapamil hydrochloride-d6	Isotope-Labeled Compounds Apoptosis Leukotriene Receptor Calcium Channel	Cancer
(S)-Verapamil-d₆ ((S)-(-)-Verapamil-d₆) hydrochloride is the deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-163369

HDAC6-IN-35	HDAC	Cancer
HDAC6-IN-35 (compound C4 (ZINC000077541942)) is a potent and BBB-penetrated HDAC6 inhibitor with the IC₅₀ of 4.7 μM. HDAC6-IN-35 shows cell toxicity against MDA-MB-231 with EC₅₀ of 40.6 μM .

HY-169264

SJYHJ-026	PROTACs Pregnane X Receptor (PXR)	Cancer
SJYHJ-026 (compound 37) is a pregnane X receptor (PXR) PROTAC degrader with the DC₅₀ of 86.6 nM and maximal degradation of 66.4%. SJYHJ-026 shows cell cytotoxic aganist SNU-C4 HiBiT-PXR KI cells with the IC₅₀ values of 97.4 μM (24 h) and 99.5 μM (72 h) (Blue: VHL ligand HY-125845,Black: linker HY-43048；Pink: PXR inhibitor HY-169277) .

HY-N2908R

Atraric acid (Standard) Methyl atrarate (Standard)	Reference Standards Androgen Receptor NO Synthase p38 MAPK NF-κB	Inflammation/Immunology Cancer
Atraric acid (Standard) is the analytical standard of Atraric acid. This product is intended for research and analytical applications. Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2].

HY-175016

NADH-IN-3	Endogenous Metabolite	Infection Metabolic Disease
NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329)) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52) .

HY-124456

Unguinol	Bacterial	Infection
Unguinol is a depsidone originally isolated from A. unguis. It is an inhibitor of pyruvate phosphate dikinase (PPDK; IC₅₀=42.3 μM). It inhibits the growth of plants utilizing C4, but not C3, carbon fixation. Unguinol also inhibits the growth of the bacteria S. aureus and V. harveyi (GI₅₀s=8.7 and 69.5 μM, respectively) and H460, MCF-7, and SF-268 cancer cells (GI₅₀s=28.2, 50.8, and 44.3 μM, respectively).

HY-169349

Androgen receptor antagonist 12	Androgen Receptor	Cancer
Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC₅₀: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research .

HY-114773

N-Undecanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.

HY-W127487

N-Octadecanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

HY-103607R

(S,R,S)-AHPC-PEG2-C4-Cl (Standard) VH032-PEG2-C4-Cl (Standard); VHL Ligand-Linker Conjugates 7 (Standard); E3 ligase Ligand-Linker Conjugates 10 (Standard)	Reference Standards E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG2-C4-Cl (Standard) is the analytical standard of (S,R,S)-AHPC-PEG2-C4-Cl (HY-103607). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-103606R

(S,R,S)-AHPC-PEG6-C4-Cl (Standard) VH032-PEG6-C4-Cl (Standard); VHL Ligand-Linker Conjugates 10 (Standard); E3 ligase Ligand-Linker Conjugates 9 (Standard)	Reference Standards E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG6-C4-Cl (Standard) is the analytical standard of (S,R,S)-AHPC-PEG6-C4-Cl (HY-103606). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-182044

MRTX849-amide-C4-(o)-carborane	Ras Apoptosis PARP Caspase CDK	Cancer
MRTX849-amide-C4-(o)-carborane is a KRAS ^G12C inhibitor with mutation selectivity for cells expressing KRAS ^G12C. MRTX849-amide-C4-(o)-carborane shows low intrinsic cytotoxicity in cancer cells. MRTX849-amide-C4-(o)-carborane covalently binds to Cys12 of KRAS ^G12C, recruits Hsp70, promotes ubiquitination, and induces proteasome-dependent degradation of the target protein. MRTX849-amide-C4-(o)-carborane inhibits the activity of the downstream ERK signaling pathway and induces apoptosis signaling in cancer cells. MRTX849-amide-C4-(o)-carborane is applicable for the research of KRAS ^G12C-positive cancers .

Cat. No.	Product Name	Type

HY-W127393

N-Nonanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.

HY-114773

N-Undecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.

HY-W127487

N-Octadecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

Cat. No.	Product Name	Target	Research Area

HY-P3395A

Catestatin sCst	PERK JNK p38 MAPK	Inflammation/Immunology
Catestatin sCst is a negative control peptide with a scrambled amino acid sequence. Catestatin sCst fails to activate human mast cells and is used to verify the specificity of Catestatin action .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991229

MK-4721 AGS-1C4D4; AGS-PSCA	Complement System	Cancer
AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a K_a value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2908

Atraric acid Methyl atrarate	Structural Classification Microorganisms Classification of Application Fields Phenols Essence, Fragrance Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	Environmental Pollutants NF-κB Androgen Receptor p38 MAPK NO Synthase
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases .

HY-113446

Leukotriene C4	Infection Natural Products Immune System Disorder Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-130429

14,15-Leukotriene C4 Eoxin C4	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases .

HY-N2908R

Atraric acid (Standard) Methyl atrarate (Standard)	Microorganisms Phenols Plants	Reference Standards Androgen Receptor NO Synthase p38 MAPK NF-κB
Atraric acid (Standard) is the analytical standard of Atraric acid. This product is intended for research and analytical applications. Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2].

Cat. No.	Product Name	Chemical Structure

HY-N0682S3

Pyridoxine-13C4 hydrochloride
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-W750796

Butyric acid-13C4 sodium

Butyric acid-13C4 sodium (Butanoic acid-13C4 sodium) is a stable isotope labeled compound with the activity of promoting cell proliferation and regulating gene expression. Butyric acid-13C4 sodium can be used in metabolic research and compound development to help scientists gain a deeper understanding of the role of short-chain fatty acids in organisms. Butyric acid-13C4 sodium also plays an important role in nutrition and intestinal health research, especially in the regulation of probiotic function and intestinal microbiota.

HY-D0844S

Glutathione oxidized-13C4,15N2 1 Publications Verification
Glutathione oxidized- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .

HY-W016498S1

Paraxanthine-13C4,15N3
Paraxanthine- ¹³C₄, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-Y0836S

Diethyl succinate-13C4
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate . Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring .

HY-N0830S

Palmitic acid-1,2,3,4-13C4
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate

L-Asparagine- ¹³C₄, ¹⁵N₂ monohydrateis the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S3

L-Asparagine-13C4 monohydrate

L-Asparagine- ¹³C₄ monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-N0667S7

L-Asparagine-13C4,15N2

L-Asparagine- ¹³C₄, ¹⁵N₂ ((-)-Asparagine- ¹³C₄, ¹⁵N₂) is the ¹³C and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-135336AS

(S)-Verapamil-d7 hydrochloride
(S)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-135336AS1

(S)-Verapamil hydrochloride-d6
(S)-Verapamil-d₆ ((S)-(-)-Verapamil-d₆) hydrochloride is the deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells .

HY-B1328S3

Pyridoxine-13C4
Pyridoxine- ¹³C₄ (Pyridoxol- ¹³C₄) is ¹³C labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-W777169

Bexarotene-13C4
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-W008449S1

1-Methylxanthine-13C4,15N3
1-Methylxanthine- ¹³C₄, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled 1-Methylxanthine. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .

HY-167857S

Glutathione Disulfide-13C4,15N2
Glutathione Disulfide- ¹³C₄, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled (Rac)-Glutipyran (HY-167857). (Rac)-Glutipyran is a broad-spectrum GLUT inhibitor that targets both GLUT1 and GLUT3. (Rac)-Glutipyran inhibits glucose uptake and suppresses the growth of multiple cancer cells, significantly inhibiting PANC-1 cell growth (IC₅₀=1.8 μM) and glucose uptake (IC₅₀=0.13 μM) .

HY-W777675

2,5-Deoxyfructosazine-13C4

2,5-Deoxyfructosazine- ¹³C₄ (NSC 270912- ¹³C₄) is the ¹³C-labeled 2,5-Deoxyfructosazine (HY-135078). 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC₅₀=~1.25 mM).

HY-W017443S4

L-Asparagine-1,2,3,4-13C4 monohydrate

L-Asparagine-1,2,3,4- ¹³C₄ monohydrate is the ¹³C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S

L-Asparagine-13C4,15N2,d8

L-Asparagine- ¹³C₄, ¹⁵N₂,d₈ is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S2

L-Asparagine-13C4,15N2,d3 monohydrate

L-Asparagine- ¹³C₄, ¹⁵N₂,d₃ monohydrate is the deuterium, ¹³C-, and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

Cat. No.	Product Name		Classification

HY-160852

YSK 12C4		Cationic Lipids
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .

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