Search Result

Results for "

CCl4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (2) Aminotransferases (Transaminases) (1) AMPK (2) Amyloid-β (2) Apoptosis (10) Autophagy (2) Bacterial (1) Bcl-2 Family (1) Bcr-Abl (1) Btk (1) c-Myc (2) Casein Kinase (1) Caspase (1) CCR (3) Collagen (2) COX (1) Cytochrome P450 (3) Drug Intermediate (1) Endogenous Metabolite (1) ERK (3) Factor Xa (1) Ferroptosis (1) FGFR (1) FLT3 (1) Fungal (1) FXR (2) GPR55 (1) Heme Oxygenase (HO) (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JAK (1) JNK (1) Keap1-Nrf2 (3) MMP (2) mRNA (1) mTOR (1) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (3) p38 MAPK (1) PAK (1) PD-1/PD-L1 (1) PGE synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (2) PROTACs (1) Reactive Oxygen Species (ROS) (7) Reference Standards (7) RIP kinase (1) Small Interfering RNA (siRNA) (5) STAT (1) TGF-beta/Smad (1) Thrombin (1) Thyroid Hormone Receptor (1) VD/VDR (2) VEGFR (2) Wnt (1) Xanthine Oxidase (2) β-glucuronidase (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (5) Endocrinology (3) Infection (1) Inflammation/Immunology (22) Metabolic Disease (18) Neurological Disease (4)
Oligonucleotides:	Chemokine & Receptors (1) Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) siRNAs (5)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0498

Bindarit Maximum Cited Publications 29 Publications Verification AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23*. Bindarit also has anti-inflammatory activity .

HY-N0823

Lithospermic acid 5+ Cited Publications (+)-Lithospermic acid	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis	Cardiovascular Disease Inflammation/Immunology
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-N0330

Momordin Ic 5 Publications Verification	Apoptosis Autophagy PI3K c-Myc	Metabolic Disease Inflammation/Immunology Cancer
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-N0373

Licochalcone B 10+ Cited Publications	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction ^[4].

HY-163897

PROTAC NCOA4 degrader-1	PROTACs Ferroptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology
PROTAC NCOA4 degrader-1 is a VHL-based PROTAC *NCOA4* degrader. PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces Fe ²⁺ elevation, ROS production, MDA content and PTGS2 mRNA expression. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl₄-induced acute liver injury model. PROTAC NCOA4 degrader-1 can be used for the researches of inflammation and immunology. (Pink: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B)) .

HY-152293

EVT801	VEGFR ERK	Cancer
EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC₅₀=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N5092

7-Methylcoumarin	Reactive Oxygen Species (ROS) Cytochrome P450	Metabolic Disease
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-152846

Flizasertib GDC-8264	RIP kinase Interleukin Related	Cardiovascular Disease Inflammation/Immunology Endocrinology
Flizasertib (GDC-8264) is an orally active, reversible and selective RIP1 inhibitor with K_i ^app values of 0.00071 μM and 0.0013 μM for human and cynomolgus monkey RIP1 kinase, respectively. Flizasertib blocks RIP1 autophosphorylation but does not affect RIP1 protein stability. Flizasertib inhibits pro-inflammatory cytokines (CCL3, *CCL4, and IL-1β*) production. Flizasertib results in inhibition of colitis and ileitis. Flizasertib can be used in the research of cardiac surgery-associated acute kidney injury .

HY-121944

Ricinine	Casein Kinase Wnt	Others
Ricinine exhibits hepatoprotection in CCl4-induced liver damage. Ricinine is also a CK1α inhibitor, and may activate Wnt pathway .

HY-N7697B

Chitobiose dihydrochloride	Others	Others
Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-145801

XT2 2 Publications Verification	NF-κB	Inflammation/Immunology
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC₅₀ of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases . XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N7327

Ochnaflavone	Phospholipase	Inflammation/Immunology
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-N9173

Cupressuflavone 1 Publications Verification	Others	Inflammation/Immunology
Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl₄-induced hepato- and nephrotoxicity in mice .

HY-N2358

Blumeatin	Others	Inflammation/Immunology
Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA) .

HY-N7697F

Chitobiose	Others	Metabolic Disease
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Thrombin COX ERK JNK Factor Xa	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-122951

Eburicoic acid 1 Publications Verification	Reactive Oxygen Species (ROS)	Cardiovascular Disease
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms . And Eburicoic acid has antidiabetic and antihyperlipidemic effects .

HY-N8389

Globulol	Bacterial Fungal PAK Akt STAT PD-1/PD-L1 Apoptosis CCR	Infection Cancer
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of *PAK4* in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of *CCL4* by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .

HY-149202

UT-11	PGE synthase	Neurological Disease Inflammation/Immunology
UT-11 is a potent and blood-brain barrier-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

HY-RS02102

CCL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4 Human Pre-designed siRNA Set A CCL4 Human Pre-designed siRNA Set A

HY-N2998

Ganoderenic acid A	β-glucuronidase	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-133019

ATX inhibitor 5	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC₅₀ of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently .

HY-178015

THR-β agonist 11	Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases .

HY-RS23028

Ccl4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl4 Rat Pre-designed siRNA Set A Ccl4 Rat Pre-designed siRNA Set A

HY-RS16594

Ccl4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl4 Mouse Pre-designed siRNA Set A Ccl4 Mouse Pre-designed siRNA Set A

HY-121271

Kadsurin	Others	Inflammation/Immunology
Kadsurin, a natural compound from the stems of Kadsura heteroclita (Schizandraceae), results in significant decreases of CCL₄- induced lipid-peroxidation products, such as thiobarbituric acid reactive substances (TBA-RS), conjugated dienes and fluorescent products in the liver of mice .

HY-120406

PLS-123	Btk Akt mTOR p38 MAPK ERK CCR Apoptosis	Cancer
LPS-123 is a covalently irreversible BTK inhibitor with an IC₅₀ of < 5 nM. LPS-123 simultaneously inhibits the catalytic activity of BTK at Tyr551 and its self-activation at Tyr223. LPS-123 inhibits phosphorylation of the AKT/mTOR and MAPK signaling pathways, activation of PLCγ2, ERK1/2, p38, AKT, and mTOR, and blocks the production of CCL3 and *CCL4* chemokines. LPS-123 exhibits significant anti-proliferative activity against various B-cell lymphoma cell lines and effectively induces apoptosis via a caspase-dependent pathway. LPS-123 also demonstrates significant antitumor activity in the OCI-Ly7 xenograft model. LPS-123 can be used for lymphoma research .

HY-121944S

Ricinine-d3	Isotope-Labeled Compounds	Others
Ricinine-d₃ is the deuterium labeled Ricinine. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

HY-N3315

Massonianoside B	Others	Inflammation/Immunology
Massonianoside B is an antioxidant, which can be isolated from Cedrus deodara pine needle. Massonianoside B exhibits radicals scavenging capacities, and restores CCL4-impaired activity of antioxidant enzymes .

HY-121944R

Ricinine (Standard)	Reference Standards Others	Others
Ricinine (Standard) is the analytical standard of Ricinine. This product is intended for research and analytical applications. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

HY-W017140R

2-Sec-butyl-3-methoxypyrazine (Standard) SBMP (Standard)	Endogenous Metabolite Reference Standards	Others
Ricinine (Standard) is the analytical standard of Ricinine. This product is intended for research and analytical applications. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

HY-N0823R

Lithospermic acid (Standard) (+)-Lithospermic acid (Standard)	Reference Standards NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis	Cardiovascular Disease Inflammation/Immunology
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .

HY-168629

FXR agonist 9	FXR	Metabolic Disease
FXR agonist 9 (compound 26) is an oral active and selectivity FXR partial agonist with the EC₅₀ of 0.09 µM (75.13 % maximum efficacy). FXR agonist 9 ameliorates pathological features in HFD and CCl₄(HY-Y0298)-induced metabolic dysfunction-associated steatohepatitis mice .

HY-172087

VDR agonist 3	VD/VDR	Inflammation/Immunology
VDR agonist 3 (Compound E15) is a potent vitamin D receptor (VDR) agonist. VDR agonist 3 can effectively inhibit HSC activation through VDR. VDR agonist 3 significantly reduces liver fibrosis without causing hypercalcemia in a CCl4-induced mouse liver fibrosis model .

HY-N12016

Fulvotomentoside B	Others	Metabolic Disease
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-N2109R

Macranthoidin A (Standard)	Reference Standards Others	Metabolic Disease
Macranthoidin A (Standard) is the analytical standard of Macranthoidin A. This product is intended for research and analytical applications. Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-106417

Limazocic SA 3443	Phosphatase Aminotransferases (Transaminases)	Metabolic Disease
Limazocic (SA 3443) is an orally active hepatoprotective agent. Limazocic can inhibit increases in serum transaminase, alkaline phosphatase activity and hepatic lipids, hydroxyproline content induced by CCl4. Limazocic can decrease the degree of hepatic necrosis, fibrosis and steatosis. Limazocic can be used for the research of chronic liver injuries .

HY-N15155

Vitexin 7-O-β-D-glucopyranoside Vitexin 7-glucoside	Others	Metabolic Disease
Vitexin 7-O-β-D-glucopyranoside (Vitexin 7-glucoside) is a flavone glycoside found in Beta vulgaris var. cicla. Vitexin 7-O-β-D-glucopyranoside shows a hepatoprotective activity in primary cultured rat hepatocytes with Carbon tetrachloride (CCl4) (HY-Y0298)-induced cell toxicity .

HY-168713

LZ-007	FXR	Metabolic Disease
LZ-007 is an agonist for farnesoid X receptor (FXR) with an EC₅₀ of 51 nM measuring by TR-FRET assay, or an EC₅₀ of 76 nM in HepG2 cell. LZ-007 exhibits good pharmacokinetic characheristics in SD rats. LZ-007 ameliorates western diet and CCl4 (HY-Y0298)-induced mice metabolic dysfunction-associated steatohepatitis

HY-178328

VDR agonist 4	VD/VDR Collagen TGF-beta/Smad MMP JAK	Metabolic Disease Inflammation/Immunology Endocrinology
VDR agonist 4 is an orally active potent VDR agonist. VDR agonist 4 exerts VDR-dependent antifibrotic activity by regulating multiple fibrosis-related genes to suppress α-SMA and collagen I production, thereby inhibiting hepatic stellate cell (HSC) activation. VDR agonist 4 improves CCl₄ (HY-RS16594)-induced hepatic fibrosis in mice. VDR agonist 4 can be used for liver fibrosis research .

HY-N5092R

7-Methylcoumarin (Standard)	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450	Metabolic Disease
7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-172258

5-HT2B antagonist-2	5-HT Receptor	Cancer
5-HT2B antagonist-2 (Compound 19c) is a 5HT_2B receptor antagonist with an IC₅₀ of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases .

HY-P11264

Cyclic peptide P1-1	GPR55 Collagen Reactive Oxygen Species (ROS) Apoptosis	Metabolic Disease Inflammation/Immunology
Cyclic peptide P1-1 is a high-potent GPR55 antagonist. Cyclic peptide P1-1 antagonizes GPR55 and suppresses collagen secretion. Cyclic peptide P1-1 reduces ROS production, attenuates ER stress, and inhibits mitochondria-associated Apoptosis. Cyclic peptide P1-1 inhibits the expression of α-SMA and COL1α. Cyclic peptide P1-1 ameliorates CCl₄ (HY-Y0298)-induce and MCD-diet-induce acute liver inflammation and fibrosis .

HY-174752

*Human CCL4L1 mRNA*	mRNA	Inflammation/Immunology
Human CCL4L1 mRNA encodes the human C-C motif chemokine ligand 4 like 1 (CCL4L1) protein, a chemokine that can induce chemotaxis of cells expressing CCR5 or CCR1.

HY-N0330R

Momordin Ic (Standard)	Reference Standards Apoptosis Autophagy PI3K c-Myc	Metabolic Disease Inflammation/Immunology Cancer
Momordin Ic (Standard) is the analytical standard of Momordin Ic. This product is intended for research and analytical applications. Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-RS02103

CCL4L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4L1 Human Pre-designed siRNA Set A CCL4L1 Human Pre-designed siRNA Set A

HY-RS02104

CCL4L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4L2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4L2 Human Pre-designed siRNA Set A CCL4L2 Human Pre-designed siRNA Set A

HY-170846

FGFRs-IN-1	FGFR VEGFR Bcr-Abl FLT3 Cytochrome P450	Inflammation/Immunology
FGFRs-IN-1 (Compound A16) is the orally active inhibitor for FGFR, that inhibits *FGFR1/2/3/4* with IC₅₀s of 2.3, 7, 11, and 163 nM, respectively. FGFRs-IN-1 also inhibits VEGFR1/2/3, Abl, and Flt3 with IC₅₀s of 61, 176, 112, 26, and 353 nM, respectively. FGFRs-IN-1 exhibits weak inhibitory efficacy against CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and inhibits epithelial-mesenchymal transition (EMT) in TGF-β1 stimulated A549 cell. FGFRs-IN-1 exhibits anti-inflammatory activity in Bleomycin (HY-17565)-induced mouse pulmonary fibrosis model and CCl₄ (HY-Y0298)-induced mouse liver fibrosis model .

HY-N0373R

Licochalcone B (Standard)	Reference Standards Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B (Standard) is the analytical standard of Licochalcone B. This product is intended for research and analytical applications. Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction ^[4].

HY-179613

D-Leucine amide-CDDO-Me-HMP	Drug Intermediate Reactive Oxygen Species (ROS) Apoptosis Keap1-Nrf2 Heme Oxygenase (HO) Bcl-2 Family Caspase	Metabolic Disease
D-Leucine amide-CDDO-Me-HMP is a prodrug composed of CDDO-Me (HY-13324) and ligustrazine (HY-N0264). D-Leucine amide-CDDO-Me-HMP can protect against CCl₄-induced liver injury. D-Leucine amide-CDDO-Me-HMP can inhibit ROS production, alleviates mitochondrial damage and inhibits cell apoptosis. D-Leucine amide-CDDO-Me-HMP can be used for the research of liver injury .

Cat. No.	Product Name	Target	Research Area