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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
DNA-alkylating
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "DNA-alkylating" in MCE Product Catalog:
202
202 Publications Verification
Cat. No.: HY-17364
CAS No.: 85622-93-1
Synonyms: NSC 362856; CCRG 81045; TMZ
Research Areas:
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
7
7 Cited Publications
Synonyms: CCNU; NSC 79037
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
3
Thio-TEPA is a DNA alkylating agent, with antitumor activity.
2
2 Cited Publications
Synonyms: Duocarmazine
Target:
Research Areas:
Vc-seco-DUBA (Duocarmazine) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco .
1
1 Cited Publications
Synonyms: NSC 615291; U-77779
Target:
Research Areas:
Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .
1
1 Cited Publications
Synonyms: MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863
Target:
Research Areas:
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity .
Target:
Research Areas:
MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity
.
Synonyms: OBI-3424; TH-3424; (R)-AST-3424
Research Areas:
(R)-Odafosfamide (OBI-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. (R)-Odafosfamide can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .
Cat. No.: HY-W018326
CAS No.: 113942-30-6
Target:
Research Areas:
Temozolomide acid is a carboxylic acid derivative of Temozolomide (HY-17364) with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer .
Cat. No.: HY-W015854
CAS No.: 62-50-0
Cat. No.: HY-B0733
CAS No.: 92118-27-9
Synonyms: S10036
Target:
Research Areas:
Fotemustine is a DNA-alkylating agent, with antitumor activity.
Cat. No.: HY-W019815
CAS No.: 759-73-9
Synonyms: ENU; N-Nitroso-N-ethylurea
Target:
Research Areas:
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders .
Cat. No.: HY-17364S
CAS No.: 208107-14-6
Research Areas:
Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.
Cat. No.: HY-172314
CAS No.: 2377718-85-7
Research Areas:
ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia .
Cat. No.: HY-153792
CAS No.: 824983-90-6
FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents .
Cat. No.: HY-12455
CAS No.: 118292-34-5
Research Areas:
Duocarmycin A is an antitumor antibiotic and DNA alkylating agent with broad-spectrum antibacterial activity, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). Duocarmycin A selectively binds to the AT-rich minor groove of DNA, forms covalent adducts by alkylating the adenine N3 residue, thereby disrupting DNA structure and inhibiting its replication and transcription. Duocarmycin A induces apoptosis, sub-G1 phase accumulation and chromatin condensation, reduces the levels of pro-caspase-3/9, and induces p53-independent p21 expression. Duocarmycin A is widely used in the research of various malignancies, including leukemia, sarcoma, glioblastoma, as well as multiple solid tumor models such as lung cancer, breast cancer, and colorectal cancer .
Cat. No.: HY-101150
CAS No.: 1394079-41-4
Research Areas:
DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .
Cat. No.: HY-136289
CAS No.: 932744-62-2
Target:
Research Areas:
MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC .
Thio-TEPA (Standard) is the analytical standard of Thio-TEPA. This product is intended for research and analytical applications. Thio-TEPA is a DNA alkylating agent, with antitumor activity.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
