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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
165 Results for "
Keap1
" in MedChemExpress (MCE) Product Catalog:
Products (165)
165 Results for "Keap1" in MCE Product Catalog:
551
551 Publications Verification
Synonyms: (1S,3R)-RSL3
Forschungsgebiete:
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells [1].
135
135 Cited Publications
Synonyms: Diferuloylmethane; Natural Yellow 3; Turmeric yellow
94
Target:
Forschungsgebiete:
4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 [1].
77
45
Category:
Simaroubaceae Terpenoids Diterpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.
Target:
23
23 Cited Publications
Target:
Forschungsgebiete:
KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation [1].
12
Target:
Forschungsgebiete:
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity [1] .
8
Category:
Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Cancer Indole Alkaloids
Target:
6
6 Cited Publications
Synonyms: Methylmaleic acid
6
Category:
Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology
Target:
4
4 Cited Publications
Art. -Nr.: HY-N0806
CAS. Nr.: 14215-86-2
4
4 Cited Publications
Art. -Nr.: HY-P75897
Reinheit: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Keap1; Keap1
Species:
Source:
4
3
3 Cited Publications
Target:
Forschungsgebiete:
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade [1] .
3
3 Cited Publications
Target:
Forschungsgebiete:
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells [1].
2
2 Cited Publications
Target:
Forschungsgebiete:
Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research [1].
2
2 Cited Publications
Synonyms: Terrestrin A
Forschungsgebiete:
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke [1] .
2
2 Cited Publications
Art. -Nr.: HY-P702829
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Keap1; Keap1
2
2 Cited Publications
Art. -Nr.: HY-N11849
CAS. Nr.: 135248-05-4
Category:
2
2 Cited Publications
Synonyms: L-Sulforaphane
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
