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Results for "

LNPs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (51) Complement System (4) DNA-PK (1) Endogenous Metabolite (1) Fluorescent Dye (3) HSV (1) Isotope-Labeled Compounds (12) Liposome (204) MDM-2/p53 (1) mRNA (3) NF-κB (1) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) PI3K (1) Prostaglandin Receptor (1) Reference Standards (1) SARS-CoV (5) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (1) Toll-like Receptor (TLR) (3) Topoisomerase (1)
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Oligonucleotides:	Antigens (1) Liposome (5) Phospholipids (17) mRNA (3) Cholesterol (3) siRNAs (1) Fluorescent Lipids (5) Pegylated Lipids (29) CpG ODNs (2) Cationic Lipids (124) Reporter Genes (1) Human Pre-designed siRNA Sets (1) Polymers (1)

290

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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Isotope-Labeled Compounds

186

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134541

SM-102 Maximum Cited Publications 45 Publications Verification	Liposome	Infection
SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-138170

ALC-0315 35+ Cited Publications	Liposome SARS-CoV	Infection
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-112758

DLin-KC2-DMA 5+ Cited Publications	Liposome	Others
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-112760

18:0 mPEG2000 PE sodium 1 Publications Verification DSPE-mPEG2000 sodium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] sodium	Liposome	Others
18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery .

HY-151507

306Oi10 1 Publications Verification	Liposome	Others
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .

HY-153378

Lipid 15	Liposome	Others
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-109163

Treprostinil palmitil INS-1009	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease .

HY-153229

Firefly luciferase mRNA-LNP 1 Publications Verification	mRNA Biochemical Assay Reagents	Others
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .

HY-147332

TCL053	Liposome	Neurological Disease
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .

HY-153373

4A3-Cit 1 Publications Verification	Liposome	Others
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

HY-156630

Ionizable lipid-1 1 Publications Verification	Liposome	Others
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .

HY-137500

NT1-014B 1 Publications Verification	Liposome Biochemical Assay Reagents	Cardiovascular Disease Neurological Disease
NT1-014B is a tryptamine-derived lipidoid. NT1-014B incorporates NT-lipidoid into BBB-impermeable lipid nanoparticles (LNPs), enabling the LNPs to cross the BBB. NT1-014B enhances brain delivery via intravenous injection. NT1-014B can be used in ischemic stroke research .

HY-139305

CL4H6 1 Publications Verification	Liposome	Cancer
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .

HY-172509

N-Tetradecyl-pSar25	Biochemical Assay Reagents Liposome	Others
N-Tetradecyl-pSar25 (Compound C14-pSar25) is a polysarcosine (pSar) lipid. PSar lipids exhibit maintained or even enhanced *LNP* transfection efficiency .

HY-154974

LNP Lipid-8	Liposome	Cancer
LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8+ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases .

HY-153879

C12-TLRa	Liposome Toll-like Receptor (TLR)	Infection Inflammation/Immunology
C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine .

HY-170704

DSPE-PEG2000-TCO	Liposome	Metabolic Disease Cancer
DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .

HY-150115

Lipid 10 1 Publications Verification	Liposome	Others
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-177069

4A3-SC7	Liposome	Others
4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform .

HY-153852

LNP Lipid-7	Liposome	Others
LNP Lipid-7 is a cationic lipid. LNP Lipid-7 can be used to prepare lipid nanoparticles (LNPs) for the delivery of drugs such as nucleic acids .

HY-W590531

80-O16B	Biochemical Assay Reagents Liposome	Others
80-O16B is an ionizable cationic lipid containing disulfide bonds that can be used to prepare lipid nanoparticles (LNP) .

HY-160553

9322-O16B	Liposome	Others
9322-O16B, an ionizable cationic lipid, is used for LNP generation .

HY-W598178

93-O17O	Liposome	Others
93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .

HY-159700

AA3-DLin	Liposome	Infection
AA3-DLin is an ionizable cationic lipid with a pK_a value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .

HY-153186

LNP Lipid-3	Liposome	Others
LNP Lipid-3 is an ionizable lipid that can be used to synthesize lipid nanoparticles. LNP Lipid-3 can be applied in the research of drug delivery .

HY-160552

244cis	Liposome	Others
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .

HY-134782

OF-Deg-Lin	Liposome	Others
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-150118

Lipid 8	Liposome	Others
Lipid 8 is an ionizable amino lipid that can be used to synthesize lipid nanoparticles (LNPs). Lipid 8 is applicable to research in drug delivery .

HY-153231A

*eGFP mRNA-LNP* (500 ng/μL)**	Fluorescent Dye Liposome	Others
eGFP mRNA-LNP (500 ng/μL) is a lipid nanoparticle (LNP) containing eGFP mRNA. eGFP mRNA-LNP carries Enhanced Green Fluorescent Protein (eGFP), which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry (excitation wavelength = 488 nm; emission wavelength = 535/40 bandpass). eGFP mRNA-LNP can be used for RNA delivery, translation efficiency and cell viability .

HY-112763

CLinDMA	Liposome	Inflammation/Immunology
CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .

HY-148363

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate	Liposome	Inflammation/Immunology
Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate can be used in lipid nanoparticles (LNP) delivery systems for mRNA vaccine delivery .

HY-173287

LNP Lipid-48	Liposome	Others
LNP Lipid-48 is an SM-102 analog used in the formation of lipid nanoparticles (LNPs).

HY-153376

LNP Lipid-6	Liposome	Others
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) .

HY-153375

LNP Lipid-5	Liposome	Others
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP) .

HY-160578

Glucosamine Cholesterol N-Cholesteryl succinyl glucosamine	Liposome	Others
Glucosamine Cholesterol (N-Cholesteryl succinyl glucosamine) is a glucosamine-based lipid conjugate, and can be used in the formation of lipid nanoparticles (LNPs) .

HY-D2762

18:1 PE AF 594 triammonium	Fluorescent Dye	Cancer
18:1 PE AF 594 triammonium is a fluorescently labeled phospholipid probe. 18:1 PE AF 594 triammonium can be used as a fluorescent tracer for lipid nanoparticles (LNPs). 18:1 PE AF 594 triammonium is promising for research of drug delivery systems .

HY-153187

LNP Lipid-4	Liposome	Others
LNP Lipid-4 (Compound 8-8) is a lipid compound. LNP Lipid-4 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-4 has potential applications in the transportation of biologically active substances .

HY-153136

LNP Lipid-1	Liposome	Others
LNP Lipid-1 (Method B) is a lipid compound. LNP Lipid-1 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-1 has potential applications in the transport of biologically active substances such as small molecule agents, proteins, and nucleic acids .

HY-176518

ssPalmE-P4-C2	Liposome Ser/Thr Protease	Infection Neurological Disease Metabolic Disease
ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED₅₀ of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research .

HY-150116

Lipid 1	Liposome	Others
Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-171905

N-Sterol	Liposome	Others
N-Sterol is a sterol lipid that has been used to generate lipid nanoparticles (LNPs) for delivery of mRNA in vitro and in vivo. N-Sterol LNPs are taken up in J774A.1 macrophages in a lipid composition-dependent manner via clathrin caveolae, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis at different frequencies .

HY-156630A

Ionizable lipid-1 hydrochloride	Liposome	Others
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .

HY-172344

DB-lipidoid 11-10-8	Biochemical Assay Reagents	Others
DB-lipidoid 11-10-8 is an ionizable cationic lipid (pK_a = 6.22). DB-lipidoid 11-10-8 can be used in lipid nanoparticle (LNP) studies for in vivo delivery of mRNA .

HY-175410

DOPE-C8 1,2-Dioloeoyl-sn-glycero-3-phosphoethanolamine-C8; 1,2-DOPE-C8	Liposome	Others
DOPE-C8 (1,2-Dioloeoyl-sn-glycero-3-phosphoethanolamine-C8; 1,2-DOPE-C8) is a zwitterionic phospholipid derived from DOPE that has been used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA .

HY-174286

C16-18:1 PE	Liposome	Others
C16-18:1 PE is a lipid. C16-18:1 PE has the activity of promoting membrane fusion and enhancing endosomal escape, which can significantly improve the delivery efficiency of mRNA. C16-18:1 PE is used in the synthesis of lipid nanoparticles (LNP) .

HY-160579

MIC5	Liposome	Others
MIC5 is an LNP that can be used for vaccine delivery .

HY-156100

C12-4	Liposome	Others
C12-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation.

HY-142992

LNP Lipid-2	Biochemical Assay Reagents Liposome	Others
LNP Lipid-2 is a lipid product can be used to deliver agents .

HY-Z12017

Cholesterol impurity 4	Biochemical Assay Reagents	Metabolic Disease
Cholesterol impurity 4 is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

HY-176754

TCL065	Liposome	Metabolic Disease Inflammation/Immunology
TCL065 is an ionizable lipid with a pK_a of 6.3. TCL065 can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA as well as single-guide RNA (sgRNA) both in vitro and in vivo. TCL065-containing LNPs can studied in research for Duchenne muscular dystrophy and gene-editing technologies .

Cat. No.	Product Name

HY-L251

Ionizable Lipid Compound Library

95 compounds

Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application.

To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 95 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Cat. No.	Product Name	Type

HY-134541GL

SM-102 (GMP Like)

Fluorescent Dye

SM-102 (GMP Like) is SM-102 (HY-134541) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-134541G

SM-102

Fluorescent Dye

SM-102 (GMP) is SM-102 (HY-134541) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-138170GL

ALC-0315 (GMP Like)

Fluorescent Dye

ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-D2762

18:1 PE AF 594 triammonium	Fluorescent Dye
18:1 PE AF 594 triammonium is a fluorescently labeled phospholipid probe. 18:1 PE AF 594 triammonium can be used as a fluorescent tracer for lipid nanoparticles (LNPs). 18:1 PE AF 594 triammonium is promising for research of drug delivery systems .

HY-W040193GL

DSPC (GMP Like)

1,2-Distearoyl-sn-glycero-3-PC (GMP Like); 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (GMP Like)

Fluorescent Dye

DSPC (GMP Like) (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is DSPC (HY-W040193) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

Cat. No.	Product Name	Target	Research Area

HY-P5840

Cyclo(RGDyC)	Biochemical Assay Reagents	Cancer
Cyclo(RGDyC) is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer .

HY-P5840A

Cyclo(RGDyC) TFA	Peptides	Cancer
Cyclo(RGDyC) TFA is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) TFA can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer .

HY-P11614

LCA-H10	Liposome	Cancer
LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer .

Cat. No.	Product Name

HY-K2018

OptiLNP RNA Transfection Reagent
MCE OptiLNP RNA Transfection Reagent is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into common cells.

HY-K2019

OptiLNP RNA Transfection Reagent (Stem Cells)
MCE OptiLNP RNA Transfection Reagent (Stem Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into stem cells.

HY-K2021

OptiLNP RNA Transfection Reagent (Immune Cells)
MCE OptiLNP RNA Transfection Reagent (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into immune cells.

HY-K2026

OptiLNP Short-Chain RNA Transfection Reagent
MCE OptiLNP Short-Chain RNA Transfection Reagent is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of short-chain RNA into common cells.

HY-K2020

OptiLNP RNA Transfection Reagent (Primary Immune Cells)
MCE OptiLNP RNA Transfection Reagent (Primary Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into primary immune cells.

HY-K2022

In vivo OptiLNP RNA Transfection Reagent (Systemic Effect)
MCE In vivo OptiLNP RNA Transfection Reagent (Systemic Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions systemically.

HY-K2023

In vivo OptiLNP RNA Transfection Reagent (Local Effect)
MCE In vivo OptiLNP RNA Transfection Reagent (Local Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions locally.

HY-K2025

In vivo OptiLNP RNA Transfection Reagent (Lung-targeted)
MCE In vivo OptiLNP RNA Transfection Reagent (Lung-targeted) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA via intravenous injection in experimental animals.

HY-K2024

In vivo OptiLNP RNA Transfection Reagent (Liver-targeted)
MCE In vivo OptiLNP RNA Transfection Reagent (Liver-targeted) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA via intravenous injection in experimental animals.

HY-K2028

OptiLNP Gene Editing Kit (Immune Cells)
MCE OptiLNP Gene Editing Kit (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing inimmune cells.

HY-K2027

OptiLNP Gene Editing Kit
MCE OptiLNP Gene Editing Kit is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing in common cells (adherent or suspension cells).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-137499

NT1-O12B	Alkaloids Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Liposome Endogenous Metabolite
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .

Cat. No.	Product Name	Chemical Structure

HY-W040193S

DSPC-d70
DSPC-d₇₀ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₇₀) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-W040193S3

DSPC-d83
DSPC-d₈₃ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₈₃) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-134541S6

SM-102-d4
SM-102-d₄ is the deuterium labeled SM-102 (HY-134541). SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-W040193S1

DSPC-d74
DSPC-d₇₄ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₇₄) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-W040193S6

DSPC-d13
DSPC-d₁₃ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₁₃) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-W040193S2

DSPC-d79
DSPC-d₇₉ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₇₉) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-W040193S5

DSPC-d9
DSPC-d₉ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₉) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-W040193S4

DSPC-d4
DSPC-d₄ (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₄) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-151998S

DMPG-d54
DMPG-d₅₄ is the deuterium labeled DMPG (1,2-Dimyristoyl-sn-glycero-3-phosphatidylglycerol). DMPG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

HY-W775262S

Δ9-Tetrahydrocannabinolic acid-d3
Δ9-Tetrahydrocannabinolic acid-d₃ is the deuterium labeled Δ9-Tetrahydrocannabinolic acid. Δ9-Tetrahydrocannabinolic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

HY-W583868S

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d₆₂ (1,2-POPE-d₆₂) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134541G

SM-102	Liposome	Infection
SM-102 (GMP) is SM-102 (HY-134541) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-134541GL

SM-102 (GMP Like)	Liposome	Infection
SM-102 (GMP Like) is SM-102 (HY-134541) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-W040193GL

DSPC (GMP Like) 1,2-Distearoyl-sn-glycero-3-PC (GMP Like); 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (GMP Like)	Liposome	Others
DSPC (GMP Like) (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is DSPC (HY-W040193) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system .

HY-138170GL

ALC-0315 (GMP Like)	Liposome SARS-CoV	Infection
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

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