Search Result

Isoforms Recommended:	MMP-3

Results for "

MMP3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MMP (66) Adenosine Receptor (1) Aminopeptidase (2) Amyloid-β (1) Antibiotic (4) AP-1 (3) Apoptosis (7) Autophagy (2) Bacterial (4) Bcl-2 Family (1) Caspase (3) COX (1) Epigenetic Reader Domain (2) Ferroptosis (1) Fluorescent Dye (2) Interleukin Related (3) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Leukotriene Receptor (1) Lipoxygenase (1) MAP3K (1) Microtubule/Tubulin (1) Mitophagy (1) NF-κB (1) Notch (1) P2Y Receptor (1) PINK1/Parkin (1) Progesterone Receptor (1) Protease Activated Receptor (PAR) (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (8) Small Interfering RNA (siRNA) (3) Thrombin (2) TNF Receptor (4) VEGFR (2)
By Research Areas:	Cancer (32) Cardiovascular Disease (9) Endocrinology (1) Infection (4) Inflammation/Immunology (23) Metabolic Disease (1) Neurological Disease (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Targets Recommended: MMP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15768

Ilomastat 60+ Cited Publications GM6001; Galardin	MMP	Cancer
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-12270

T-5224 Maximum Cited Publications 100 Publications Verification	AP-1 MMP	Neurological Disease Inflammation/Immunology Cancer
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-N0262

Cordycepin Maximum Cited Publications 13 Publications Verification 3'-Deoxyadenosine	TNF Receptor MMP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced *MMP-1* and *MMP-3* expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-13564

Batimastat 15+ Cited Publications BB94	MMP	Cancer
Batimastat is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-N1463

Luteolin 7-O-glucuronide 3 Publications Verification Luteolin 7-glucuronide	MMP	Neurological Disease Inflammation/Immunology
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities ^[3] .

HY-110397

KP-457 3 Publications Verification	MMP	Cardiovascular Disease
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

HY-107394

UK 356618 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC₅₀ of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with *MMP-3* .

HY-N1454

Apigenin-7-glucuronide 4 Publications Verification Apigenin 7-O-glucuronide	MMP	Cancer
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-103444

ARP-100 1 Publications Verification	MMP	Cancer
ARP-100 is a potent and selective matrix metalloproteinase *MMP-2* inhibitor (IC₅₀=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) .

HY-114418

MMP3 inhibitor 1 1 Publications Verification	MMP	Cancer
MMP3 inhibitor 1 is a potent and highly selective *MMP-3* inhibitor with an IC₅₀ of 1 nM .

HY-119711

NNGH	MMP	Cancer
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression .

HY-12170

Prinomastat 4 Publications Verification AG3340; KB-R9896	MMP Apoptosis	Cancer
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3, MMP-13* and *MMP-9* with K_is of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity ^[3] .

HY-114164G

Murine Thrombin 5+ Cited Publications	Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of MCP-1, *MMP3* and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus ^[3] .

HY-108672

NF157	P2Y Receptor	Inflammation/Immunology
NF157 is a highly selective nanomolar P2Y11 antagonist with a pK_i of 7.35. The IC₅₀s are 463 nM, 1811 µM, 170 µM for P2Y11 (K_i=44.3 nM), P2Y1 (K_i=187 µM), P2Y2 (K_i=28.9 µM), respectively . NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA) .

HY-12170A

Prinomastat hydrochloride 4 Publications Verification AG3340 hydrochloride; KB-R9896 hydrochloride	MMP Apoptosis	Cancer
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat hydrochloride inhibits MMP-2, MMP-3, MMP-13* and *MMP-9* with K_is of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity ^[3] .

HY-107639

UK-370106	MMP	Inflammation/Immunology
UK-370106 is a potent and highly selective *MMP-3* (IC₅₀ of 23 nM) and *MMP-12* (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [ ³H]-fibronectin by *MMP-3* (IC₅₀ of 320 nM) and has little effect on keratinocyte migration in vitro .

HY-19485

XL-784 2 Publications Verification	MMP	Cardiovascular Disease
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-107428

PD-166793	MMP	Cardiovascular Disease
PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of *MMP, exhibiting nanomolar potency against MMP-2, MMP-3* and *MMP-13* (IC₅₀=4, 7, and 8 nM, respectively) and micromolar potency vs *MMP-1, -7 and -9 (IC₅₀*=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure ^[3].

HY-13564A

Batimastat sodium salt 15+ Cited Publications BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-15606

Tanaproget 1 Publications Verification NSP-989	Progesterone Receptor	Endocrinology
Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC₅₀ of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research ^[3].

HY-12168

Tanomastat BAY 12-9566	MMP	Cancer
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The K_i values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models ^[3].

HY-P2185A

NFF-3 TFA	MMP	Others
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-169949

TAK-756	MAP3K NF-κB MMP Leukotriene Receptor	Inflammation/Immunology
TAK-756 is a selective transforming growth factor β-activated kinase 1 (TAK1) inhibitor with a target pIC₅₀ of 8.6. TAK-756 can inhibit TAK1 autophosphorylation and downstream NF-κB phosphorylation, suppress the production of inflammatory and catabolic factors such as *MMP-3* and IL-6. TAK-756 exhibits anti-inflammatory effects in a rat joint inflammation model. TAK-756 can be used for the research of inflammatory joint disease, osteoarthritis .

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression ^[3].

HY-P2166

MMP3 inhibitor 3	MMP	Cancer
MMP3 inhibitor 3 is an inhibitor of *MMP3. MMP3* inhibitor 3 can used to study breast cancer .

HY-W011085

CP-471474 1 Publications Verification	MMP	Inflammation/Immunology
CP-471474 is an orally active and pan *MMP* inhibitor, with IC₅₀ values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively .

HY-119423

MMP Inhibitor II	MMP	Cancer
MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC₅₀ values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively .

HY-N0262R

Cordycepin (Standard) 3'-Deoxyadenosine (Standard)	TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-114091

PF-00356231 hydrochloride 2 Publications Verification	MMP	Inflammation/Immunology
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase *MMP-12* (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively .

HY-164826

Acetyl zingerone	Interleukin Related Reactive Oxygen Species (ROS) MMP Pyroptosis Ferroptosis Notch Keap1-Nrf2 PINK1/Parkin Mitophagy Caspase Apoptosis	Inflammation/Immunology Cancer
Acetyl zingerone is an analog of Zingerone (HY-14621). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and IL-17A target genes. Acetyl zingerone inhibits the activities of *MMP-1, MMP-3, and MMP-12, as well as the activation of NLRP3* inflammasome, pyroptosis (pyroptosis), ferroptosis (ferroptosis), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen, proteoglycan, extracellular matrix glycoprotein, Notch pathway, and GPX4 gene, activates Nrf2 and HO-1, induces extracellular matrix synthesis and PINK1/Parkin-mediated mitophagy (mitophagy), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer ^[3] .

HY-N16409

Berkeleyamide C	MMP Caspase	Inflammation/Immunology Cancer
Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases .

HY-P2166A

MMP3 inhibitor 3 TFA	MMP	Cancer
MMP3 inhibitor 3 (TFA) is an inhibitor of *MMP3. MMP3* inhibitor 3 (TFA) can used to study breast cancer .

HY-RS08548

MMP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
MMP3 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP3 Human Pre-designed siRNA Set A MMP3 Human Pre-designed siRNA Set A

HY-RS08549

Mmp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Mmp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp3 Mouse Pre-designed siRNA Set A Mmp3 Mouse Pre-designed siRNA Set A

HY-P3699

TNO003	MMP Fluorescent Dye	Others
TNO003 is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm) .

HY-RS08550

Mmp3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Mmp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp3 Rat Pre-designed siRNA Set A Mmp3 Rat Pre-designed siRNA Set A

HY-112160

XL-784 free base	MMP	Cardiovascular Disease
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively .

HY-N1454R

Apigenin-7-glucuronide (Standard) Apigenin 7-O-glucuronide (Standard)	Reference Standards MMP	Cancer
Apigenin-7-glucuronide (Standard) is the analytical standard of Apigenin-7-glucuronide. This product is intended for research and analytical applications. Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-P2185

NFF-3	MMP	Others
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-114164F

Canine Thrombin	Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain	Cardiovascular Disease
Canine Thrombin is a Canine serine protease that plays a central role in blood coagulation. Canine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Canine Thrombin activates PAR1, induces the production of MCP-1, *MMP3* and VEGF in intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Canine Thrombin activity increases significantly in paraoxon-induced status epilepticus ^[3] .

HY-P3202

Matrix metalloproteinase 3 MMP-3; Stromelysin-1	MMP	Neurological Disease
Matrix metalloproteinase 3 (MMP-3) is a member of the class of zinc-dependent proteases that can degrade the extracellular matrix (ECM). Matrix metalloproteinase 3 palys an important role in the neuronal apoptotic process as well as in neuroinflammation. Matrix metalloproteinase 3 can be used in the study of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .

HY-P3098

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	MMP	Others
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-N16408

Berkeleyamide B	MMP Caspase	Inflammation/Immunology Cancer
Berkeleyamide B is a dual matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide B is promising for research of cancers and inflammatory disease (e.g., rheumatoid arthritis) .

HY-18694

CGS 27023A	MMP	Inflammation/Immunology
CGS 27023A is a non-peptidic and orally active *MMP* inhibitor with the K_i values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A can be used for study of arthritis .

HY-167825

Barakol	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Barakol is a major compound found in Cassia siamea. Barakol inhibits *MMP-3* activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects ^[3].

HY-117464

CM-352	MMP	Cardiovascular Disease
CM-352 (compound 5) is an inhibitor of matrix metalloproteinases (MMPs) (MMP-3: IC₅₀=15 nM; *MMP-10: IC₅₀=12 nM). CM-352 has significant antifibrinolytic activity (EC₅₀*=0.7 nM) and can significantly prolong blood coagulation time. CM-352 can be used in anti-bleeding research .

HY-15768R

Ilomastat (Standard) GM6001 (Standard); Galardin (Standard)	MMP Reference Standards	Cancer
Ilomastat (Standard) is the analytical standard of Ilomastat. This product is intended for research and analytical applications. Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-137370

2-Hexynyl-5′-N-ethylcarboxamidoadenosine HENECA; 2-Hexynyl-NECA	Adenosine Receptor Amyloid-β	Neurological Disease
2-Hexynyl-5′-N-ethylcarboxamidoadenosine (HENECA) is a selective A_2A adenosine receptor agonist. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine increases intracellular cAMP level, and inhibits TNFα-evoked MMP-3 release. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine induces Aβ42 production in SH-SY5Y cells ^[3].

HY-152030

*Tubulin/MMP-IN-2*	Microtubule/Tubulin MMP Apoptosis	Cancer
Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC₅₀ values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer .

Cat. No.	Product Name	Type

HY-P2185

NFF-3	Fluorescent Dye
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P3098

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	Fluorescent Dye
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-110397G

KP-457

Fluorescent Dye

KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

Cat. No.	Product Name	Type

HY-110397G

KP-457

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P2185A

NFF-3 TFA	MMP	Others
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P2166

MMP3 inhibitor 3	MMP	Cancer
MMP3 inhibitor 3 is an inhibitor of *MMP3. MMP3* inhibitor 3 can used to study breast cancer .

HY-P2166A

MMP3 inhibitor 3 TFA	MMP	Cancer
MMP3 inhibitor 3 (TFA) is an inhibitor of *MMP3. MMP3* inhibitor 3 (TFA) can used to study breast cancer .

HY-P3699

TNO003	MMP Fluorescent Dye	Others
TNO003 is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm) .

HY-P2185

NFF-3	MMP	Others
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P3098

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	MMP	Others
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-P4937

NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2	MMP	Cancer
NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 is an substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3) and can be easily detected at Abs/Em=350/465 nm .

HY-P2089

Dnp-PYAYWMR	MMP	Others
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0262

Cordycepin Maximum Cited Publications 13 Publications Verification 3'-Deoxyadenosine	Infection Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification Cancer	TNF Receptor MMP Bacterial Autophagy Antibiotic
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced *MMP-1* and *MMP-3* expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-N1463

Luteolin 7-O-glucuronide 3 Publications Verification Luteolin 7-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	MMP
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Infection Natural Products Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Source Classification	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities ^[3] .

HY-N1454

Apigenin-7-glucuronide 4 Publications Verification Apigenin 7-O-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	MMP
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Flavonols Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression ^[3].

HY-N0262R

Cordycepin (Standard) 3'-Deoxyadenosine (Standard)	Structural Classification Natural Products Microorganisms Source Classification	TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic
Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-N16409

Berkeleyamide C	Natural Products Microorganisms Source Classification	MMP Caspase
Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases .

HY-N1454R

Apigenin-7-glucuronide (Standard) Apigenin 7-O-glucuronide (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards MMP
Apigenin-7-glucuronide (Standard) is the analytical standard of Apigenin-7-glucuronide. This product is intended for research and analytical applications. Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-N16408

Berkeleyamide B	Natural Products Microorganisms Source Classification	MMP Caspase
Berkeleyamide B is a dual matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide B is promising for research of cancers and inflammatory disease (e.g., rheumatoid arthritis) .

HY-167825

Barakol	Seeds of Cassia tora Linn. Natural Products Leguminosae Plants Source Classification	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)
Barakol is a major compound found in Cassia siamea. Barakol inhibits *MMP-3* activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects ^[3].

HY-N1463R

Luteolin 7-O-glucuronide (Standard) Luteolin 7-glucuronide (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards MMP
Luteolin 7-O-glucuronide (Standard) is the analytical standard of Luteolin 7-O-glucuronide. This product is intended for research and analytical applications. Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-113952R

Actinonin (Standard) (-)-Actinonin (Standard)	Natural Products Microorganisms Source Classification	Reference Standards Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

Recombinant Proteins Recommended:

MMP-3

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70139

	*Stromelysin-1/MMP-3* Protein, Human (HEK293, His)** rHuStromelysin-1/MMP-3, His; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1; MMP3; STMY1	Human	HEK293
	The Stromelysin-1/MMP-3 protein is a multifunctional metalloprotease that degrades a variety of extracellular matrix components and activates molecules such as growth factors, plasminogen, and MMP9. It is released into the ECM and is activated through the plasmin cascade. Stromelysin-1/MMP-3 Protein, Human (HEK293, His) is the recombinant human-derived Stromelysin-1/MMP-3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73297

	*Stromelysin-1/MMP-3* Protein, Human** Stromelysin-1; SL-1; MMP-3; Transin-1; STMY1	Human	E. coli
	The Stromelysin-1/MMP-3 protein is a multifunctional metalloprotease that degrades a variety of extracellular matrix components and activates molecules such as growth factors, plasminogen, and MMP9. It is released into the ECM and is activated through the plasmin cascade. Stromelysin-1/MMP-3 Protein, Human is the recombinant human-derived Stromelysin-1/MMP-3 protein, expressed by E. coli , with tag free.

HY-P79097

	MMP-16 Protein, Human (I152N, His) Matrix metalloproteinase-16; MMP16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; C8orf57; MMPX2; Matrix Metalloproteinase 16/Membrane Type 3 MMP	Human	E. coli
	The MMP-16 protein functions as an endopeptidase capable of degrading various components of the extracellular matrix, particularly type III collagen and fibronectin. Its effects extend to the activation of progelatinase A, which contributes to the dynamic remodeling of the extracellular matrix within blood vessels. MMP-16 Protein, Human (I152N, His) is the recombinant human-derived MMP-16 protein, expressed by E. coli , with C-10*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-12270S

T-5224-d8
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) WB (2) ELISA (1)
Isotype:	IgG (1) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86555

	MMP3 Antibody (YA6247) MMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	MMP3 Antibody (YA6247) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP3.

HY-P80424

	MMP3 Antibody (YA286)	WB, IHC-P	Human, Mouse, Rat
	MMP3 Antibody (YA286) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP3.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Targets Recommended: MMP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110397G

KP-457	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

MMP3

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Natural
Products