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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
MTX
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "MTX" in MCE Product Catalog:
17
17 Publications Verification
Synonyms: Leucovorin calcium; Calcium folinate
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17
Category:
Human Gut Microbiota Metabolites Natural Products Plants Moraceae Endogenous metabolite Disease Research Fields Cancer Morus alba Linn.
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17
17 Publications Verification
Synonyms: Leucovorin calcium salt pentahydrate
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3
1
1 Cited Publications
Synonyms: PROTAC AR-V7 degrader-2
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MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC50 values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer .
Cat. No.: HY-160019
CAS No.: 2750895-97-5
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MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine .
Cat. No.: HY-162713
CAS No.: 2791417-66-6
MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC50 of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors .
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7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
Cat. No.: HY-W047788
CAS No.: 10270-94-7
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Cat. No.: HY-115429
CAS No.: 115940-48-2
Synonyms: (6R)-Leucovorin calcium; (6R)-Folinic acid calcium
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Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .
Cat. No.: HY-13617
CAS No.: 80576-83-6
Synonyms: CGP 30694
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Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck .
Cat. No.: HY-P11101
CAS No.: 2294870-89-4
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Cat. No.: HY-156872
CAS No.: 1952236-19-9
MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1 LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC50 of 281 nM. MTX-216 is used in the research of Melanoma .
Cat. No.: HY-180121
CAS No.: 1589522-50-8
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tBu-MTX-CO-NH-C2-O-C2-N3 (Compound 4a) is an azide compound, which can be used as a drug intermediate for the construction of chemical inducers of dimerisation.
Cat. No.: HY-17556A
CAS No.: 163254-40-8
Synonyms: Leucovorin disodium
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Cat. No.: HY-RS08828
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MTX1 Human Pre-designed siRNA Set A contains three designed siRNAs for MTX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: Leucovorin calcium (Standard); Calcium folinate (Standard)
Cat. No.: HY-W653912A
Cat. No.: HY-149556
CAS No.: 3036637-30-3
MTX-241F is a selective small molecule inhibitor targeting EGFR and PI3 kinase family members. MTX-241F is able to penetrate the blood-brain barrier and control tumor growth over the long term. MTX-241F exhibits radiosensitizing activity in patient-derived DIPG neurospheres and may be used in the study of diffuse intrinsic pontine glioma (DIPG) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
