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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
52 Results for "
Melanocortin Agonist
" in MedChemExpress (MCE) Product Catalog:
Products (52)
52 Results for "Melanocortin Agonist" in MCE Product Catalog:
25
25 Publications Verification
Synonyms: α-Melanocyte-Stimulating Hormone
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
25
25 Publications Verification
Cat. No.: HY-P0252A
CAS No.: 171869-93-5
Synonyms: α-Melanocyte-Stimulating Hormone TFA
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Neurological Disease Metabolic Disease Inflammation/Immunology
3
3 Cited Publications
Cat. No.: HY-P0227
CAS No.: 168482-23-3
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1
1 Cited Publications
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THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
1
1 Cited Publications
Cat. No.: HY-P0267
CAS No.: 121062-08-6
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1
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Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .
1
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1
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1
1 Cited Publications
Cat. No.: HY-N2466A
CAS No.: 1566590-77-9
Synonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
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Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) acetate is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I acetate induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I acetate impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I acetate can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .
Cat. No.: HY-P1211
CAS No.: 12279-41-3
Synonyms: 1-39-Corticotropin (human)
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Synonyms: MT-7117
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Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation .
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PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM . Pf-446687 is brain penetrant .
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MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity .
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BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC50 of 120 nM, an EC50 of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties .
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MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake .
Cat. No.: HY-P0060
CAS No.: 16960-16-0
Synonyms: Tetracosactrin; ACTH(1–24)
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Cat. No.: HY-P0060A
CAS No.: 60189-34-6
Synonyms: Tetracosactrin acetate; ACTH(1–24) acetate
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Synonyms: AP1189 acetate
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Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca 2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research .
Cat. No.: HY-P1477
CAS No.: 77465-10-2
Synonyms: ACTH(1-39), rat
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Cat. No.: HY-P1477A
Synonyms: ACTH(1-39), rat TFA
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
