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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
145 Results for "
NAFLD
" in MedChemExpress (MCE) Product Catalog:
Products (145)
145 Results for "NAFLD" in MCE Product Catalog:
24
24 Publications Verification
Cat. No.: HY-W018392
CAS No.: 4376-20-9
Synonyms: MEHP; Phthalic acid mono-2-ethylhexyl ester
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9
9 Cited Publications
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E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
9
9 Cited Publications
Research Areas:
E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
5
5 Cited Publications
Cat. No.: HY-N0401A
CAS No.: 81944-09-4
Category:
Natural Products Umbelliferae Extract Metabolic Disease Dicerothamnus rhinocerotis Plants Disease Research Fields
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3
3 Cited Publications
Cat. No.: HY-N0914
CAS No.: 52949-83-4
3
3 Cited Publications
Cat. No.: HY-N2181
CAS No.: 24502-78-1
Category:
Quinones Boraginaceae Extract Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Inflammation/Immunology Naphthalene Quinones
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2
2 Cited Publications
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L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases .
2
2
2 Cited Publications
Cat. No.: HY-N3101
CAS No.: 22384-63-0
1
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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1
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Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) .
1
1 Cited Publications
Cat. No.: HY-W018392S
CAS No.: 1276197-22-8
Synonyms: MEHP-d4; Phthalic acid mono-2-ethylhexyl ester-d4
1
1 Cited Publications
Cat. No.: HY-N0723
CAS No.: 64809-67-2
1
1 Cited Publications
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Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .
1
Category:
Cat. No.: HY-W018004
CAS No.: 1190-49-4
Cat. No.: HY-P99614
CAS No.: 2517935-02-1
Synonyms: BFKB8488A; RG-7992; RO-7040551
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ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation .
Cat. No.: HY-153476
CAS No.: 2807481-02-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
