Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
263 Results for "
Neurotrophic
" in MedChemExpress (MCE) Product Catalog:
Products (263)
263 Results for "Neurotrophic" in MCE Product Catalog:
21
21 Publications Verification
Cat. No.: HY-W013372
CAS No.: 38183-03-8
Category:
Flavonoids Umbelliferae Extract Flavones Phenols Polyphenols Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray
Target:
15
15 Cited Publications
Cat. No.: HY-P7116A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived Neurotrophic Factor; Brain-Derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; Brain-Derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; Brain-Derived Neurotrophic Factor; BULN2
Species:
Mouse
Rat
Human
Source:
E. coli
9
Amitriptyline is an orally active tricyclic antidepressant (TCA). Amitriptyline mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline can reduce inflammation, angiogenesis and fibrosis. Amitriptyline binds to DAT (with Ki = 2.58 μM). Amitriptyline has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity .
9
Target:
Serotonin Transporter 5-HT Receptor mAChR Histamine Receptor Adrenergic Receptor Trk Receptor Sodium Channel Potassium Channel Dopamine Transporter Apoptosis
Research Areas:
Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with Ki = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity .
5
5 Cited Publications
Cat. No.: HY-P7182
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
E. coli
5
5 Cited Publications
Target:
Research Areas:
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD) .
5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P74383
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived Neurotrophic Factor; Brain-Derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; Brain-Derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; Brain-Derived Neurotrophic Factor; BULN2
Species:
Mouse
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P7359
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Mouse
Source:
CHO
2
2
2 Cited Publications
Cat. No.: HY-P71940A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MANF; Arginine-Rich, Mutated In Early Stage Tumors; Prev. ARMET; Protein ARMET; ARP; DDDS; Mesencephalic Astrocyte-Derived Neurotrophic Factor; Mesencephalic Astrocyte Derived Neurotrophic Factor; Arginine-Rich Protein
Species:
Human
Source:
E. coli
2
2
1
1 Cited Publications
Cat. No.: HY-W013573
CAS No.: 21593-77-1
Category:
Natural Products Neurological Disease Anti-aging Metabolic Disease Allium sativum Linn. Plants Liliaceae Extract Disease Research Fields Inflammation/Immunology Cancer
Target:
1
1 Cited Publications
Target:
Research Areas:
1
1 Cited Publications
Target:
Research Areas:
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF) . BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function .
1
1 Cited Publications
Cat. No.: HY-N4191
CAS No.: 93780-80-4
Category:
Neurological Disease Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Phenols Polyphenols Diterpenoids Plants Disease Research Fields Labiatae Extract
Target:
1
1 Cited Publications
Cat. No.: HY-P700158AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived Neurotrophic Factor; Brain-Derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; Brain-Derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; Brain-Derived Neurotrophic Factor; BULN2
Species:
Rat
Mouse
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73074
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; Glial Cell Line Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor; Glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
HEK293
1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
