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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
Orphan Nuclear Receptor
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "Orphan Nuclear Receptor" in MCE Product Catalog:
18
18 Publications Verification
Art. -Nr.: HY-N2148
CAS. Nr.: 321661-62-5
Synonyms: Csn-B; Dothiorelone G
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ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers .
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1 Cited Publications
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DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
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NR2F2-IN-1 (COUP-TFII inhibitor) free base is a small-molecule inhibitor targeting the orphan nuclear receptor COUP-TFII (NR2F2). NR2F2-IN-1 free base directly binds to the ligand-binding domain of COUP-TFII (NR2F2) and disrupts its interaction with transcriptional regulators including FOXA1. NR2F2-IN-1 free base induces anti-tumor activity in prostate cancer and can be used for prostate cancer research .
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TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity .
Art. -Nr.: HY-156190
CAS. Nr.: 1049691-47-5
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Forschungsgebiete:
NR2F2-IN-1 (COUP-TFII inhibitor) is a small-molecule inhibitor targeting the orphan nuclear receptor COUP-TFII (NR2F2). NR2F2-IN-1 directly binds to the ligand-binding domain of COUP-TFII (NR2F2) and disrupts its interaction with transcriptional regulators including FOXA1. NR2F2-IN-1 induces anti-tumor activity in prostate cancer and can be used for prostate cancer research .
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SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases .
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BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 hydrochloride impairs the anchorage-independent growth of KEAP1-mutant cancer cells .
Art. -Nr.: HY-W649594
CAS. Nr.: 22978-55-8
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Forschungsgebiete:
NR2F6 modulator-2 (Compound I) is an autorepressed orphan nuclear receptor NR2F6 (Nuclear Receptor subfamily 2 group F member 6) modulator. NR2F6 modulator-2 can inhibits the recruitment of the bio-NSD1 peptide with an IC50 of 2.0 equivalents of NR2F6. NR2F6 modulator-2 can be used for the researches of cancer and immunology .
Art. -Nr.: HY-W722556
CAS. Nr.: 7657-50-3
Synonyms: 3α,5α-Androstanol
Forschungsgebiete:
5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms .
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Forschungsgebiete:
BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells .
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Forschungsgebiete:
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R
Art. -Nr.: HY-118912
CAS. Nr.: 457937-39-2
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Forschungsgebiete:
BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) . BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models .
Art. -Nr.: HY-N2148R
CAS. Nr.: 321661-62-5
Synonyms: Csn-B (Standard); Dothiorelone G (Standard)
Category:
Art. -Nr.: HY-120785A
CAS. Nr.: 2309312-90-9
Target:
Forschungsgebiete:
SR1555 hydrochloride is the hydrochloride salt form of SR1555 (HY-120785). SR1555 hydrochloride is an inverse agonist for retinoic acid receptor-related orphan nuclear receptor γ (RORγ) with an IC50 of 1 μM. SR1555 hydrochloride inhibits the development and function of pro-inflammatory TH17 cell, increases the frequency of anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride can be used for research about autoimmune diseases .
Art. -Nr.: HY-P701396
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NR1I2; Nuclear Receptor subfamily 1 group I member 2; Orphan Nuclear Receptor PAR1; Orphan Nuclear Receptor PXR; Pregnane X Receptor; Steroid and xenobiotic Receptor; SXR
Art. -Nr.: HY-P701400
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RORA; Nuclear Receptor ROR-alpha; Nuclear Receptor RZR-alpha; Nuclear Receptor subfamily 1 group F member 1; RAR-related Orphan Receptor A; Retinoid-related Orphan Receptor-alpha
Species:
Source:
Art. -Nr.: HY-P701397
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NR1I2; Nuclear Receptor subfamily 1 group I member 2; Orphan Nuclear Receptor PAR1; Orphan Nuclear Receptor PXR; Pregnane X Receptor; Steroid and xenobiotic Receptor; SXR
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
