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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
PDGF-BB
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "PDGF-BB" in MCE Product Catalog:
29
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Category:
Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids
Target:
3
Category:
Quinones Leguminosae Anthraquinones Plants Cassia angustifolia Disease Research Fields Cancer
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2
2 Cited Publications
Cat. No.: HY-P990859
Target:
Research Areas:
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1
1 Cited Publications
Cat. No.: HY-P7055A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV
Species:
Source:
1
1 Cited Publications
Cat. No.: HY-P73351
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS
Species:
Source:
Synonyms: ZINC08010136
Target:
Research Areas:
Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA) .
Synonyms: (E/Z)-Moschamine
Category:
Cardiovascular Disease Alkaloids Carthamus tinctorius L. Phenols Polyphenols Plants Compositae Disease Research Fields Indole Alkaloids
Target:
Cat. No.: HY-177655A
Synonyms: Fovista sodium
Pegpleranib (Fovista) sodium is a pegylated DNA aptamer that selectively binds to PDGF-BB and PDGF-AB homodimers and heterodimers, interrupting the interaction with their associated tyrosine kinase receptors.
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Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .
Cat. No.: HY-162888
CAS No.: 2376694-72-1
Research Areas:
WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension .
Target:
Cat. No.: HY-177655
CAS No.: 1618657-13-8
Synonyms: Fovista
Pegpleranib (Fovista) is a pegylated DNA aptamer that selectively binds to PDGF-BB and PDGF-AB homodimers and heterodimers, interrupting the interaction with their associated tyrosine kinase receptors.
Cat. No.: HY-W755295
CAS No.: 54240-36-7
Target:
Research Areas:
Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
