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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
ROC
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "ROC" in MCE Product Catalog:
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3 Cited Publications
ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis .
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KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively .
Cat. No.: HY-N11478
CAS No.: 1319743-81-1
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ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .
Cat. No.: HY-N15737
CAS No.: 50982-40-6
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Cat. No.: HY-19356B
CAS No.: 1699754-37-4
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(+)-Rocaglamide is the dextrorotatory enantiomer of Rocaglamide (HY-19356). Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of 50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .
Cat. No.: HY-103706R
CAS No.: 1859141-26-6
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ROC-325 (Standard) is the analytical standard of ROC-325 (HY-103706). This product is intended for research and analytical applications. ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis .
Cat. No.: HY-N15735
CAS No.: 219986-51-3
Synonyms: 2-Caffeoylpiscidic acid
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Cat. No.: HY-P10065
CAS No.: 289480-71-3
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Cat. No.: HY-W718678
CAS No.: 94840-69-4
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6-Hydroxymelatonin glucuronide is a metabolite of Melatonin (HY-B0075). 6-Hydroxymelatonin glucuronide can be used for the research on the diagnosis of hepatocellular carcinoma (HCC) .
Cat. No.: HY-P81379A
Synonyms: ROC1; RNF75; RBX1; E3 ubiquitin-protein ligase RBX1; RING finger protein 75; RING-box protein 1 (Rbx1)
Cat. No.: HY-P87951
Synonyms: RNF75, ROC1, RBX1, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein transferase RBX1, Protein ZYP, RING finger protein 75, RING-box protein 1, Regulator of cullins 1, Rbx1
Cat. No.: HY-P702790
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF7; Sensitive To Apoptosis Zinc RING Finger Protein SAG; Ring Finger Protein 7; Sensitive To Apoptosis Gene Protein; CKBBP1; CKII Beta-Binding Protein 1; ROC2; Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2; RBX2; Zinc RING
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Cat. No.: HY-P702791
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF7; Sensitive To Apoptosis Zinc RING Finger Protein SAG; Ring Finger Protein 7; Sensitive To Apoptosis Gene Protein; CKBBP1; CKII Beta-Binding Protein 1; ROC2; Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2; RBX2; Zinc RING
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
