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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
STF
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "STF" in MCE Product Catalog:
53
53 Publications Verification
STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
20
17
17 Cited Publications
Cat. No.: HY-18728
CAS No.: 724741-75-7
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells .
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2
2 Cited Publications
STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively) .
Cat. No.: HY-141831
CAS No.: 2298390-71-1
Target:
Research Areas:
STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 (Ki = 33 nM). STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1, thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity .
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells .
Cat. No.: HY-108516
CAS No.: 865565-29-3
TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively .
Cat. No.: HY-129346
CAS No.: 423744-59-6
Target:
Research Areas:
STF-038533 is a CREB target gene transcription inhibitor with the activity of inhibiting the expression of related genes. STF-038533 plays a regulatory role in cell signaling pathways and has potential application value in exploring the inhibition of CREB-related diseases .
Cat. No.: HY-189065
CAS No.: 2765654-79-1
Target:
Research Areas:
STF-3600 is a LRRK2 G2019S inhibitor with an IC50 of 0.9 nM against the human target. It has oral activity and can cross the blood-brain barrier. STF-3600 selectively inhibits kinase activity, including autophosphorylation at Ser935 and Ser1292, as well as phosphorylation of the endogenous substrate Rab10 at Thr73. STF-3600 inhibits vacuolization of type II pulmonary epithelial cells in wild-type/heterozygous mice, while it induces this vacuolization phenotype in homozygous mice. STF-3600 can be used in Parkinson's disease research .
Cat. No.: HY-149465
CAS No.: 2298391-60-1
Target:
Research Areas:
STF-1623 is a highly potent, selective, cell-impermeable non-covalent ENPP1 inhibitor, with IC50 values of 0.6 nM and 800 nM against human ENPP1 and ENPP3, respectively. STF-1623 inhibits the hydrolysis of extracellular cGAMP by ENPP1, elevates intratumoral cGAMP levels, and indirectly enhances local cGAS-STING signaling and anti-tumor immunity in tumors. STF-1623 exhibits target-dependent retention in ENPP1-highly expressing tumors, while it undergoes rapid clearance in systemic circulation, and can penetrate into the CSF and brain parenchyma. STF-1623 can be used in studies related to breast cancer, pancreatic cancer, colorectal cancer, glioblastoma, and tumor immunology .
Cat. No.: HY-P80274
Synonyms: IPF1, STF1, PDX1, Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, Insulin promoter factor 1, Insulin upstream factor 1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, GSF, IPF-1, IUF-1, IDX-1, STF-1
Cat. No.: HY-P89405
Synonyms: IPF1, STF1, PDX1, Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, Insulin promoter factor 1, Insulin upstream factor 1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, GSF, IPF-1, IUF-1, IDX-1, STF-1
Cat. No.: HY-P89405A
Synonyms: IPF1, STF1, PDX1, Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, Insulin promoter factor 1, Insulin upstream factor 1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, GSF, IPF-1, IUF-1, IDX-1, STF-1
Cat. No.: HY-P71202
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PHLDA2; Imprinted In Placenta And Liver Protein; Prev. TSSC3; P17-BWR1C; BWR1C; Tumor Suppressing Subchromosomal Transferable Fragment CDNA 3; HLDA2; Pleckstrin Homology-Like Domain, Family A, Member 2; IPL; Tumor-Suppressing STF CDNA 3 Protein; Tumor-Sup
Species:
Human
Source:
E. coli
Cat. No.: HY-P706318
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Steroidogenic factor 1; SF-1; STF-1; Adrenal 4-binding protein; Embryonal LTR-binding protein (ELP); Embryonal long terminal repeat-binding protein;
Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP; Steroid hydroxylase positive regulator; Nr5a1; Ftzf1
Species:
Mouse
Source:
E. coli Cell-free
Cat. No.: HY-P703128
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NR5A1; STF-1; Prev. FTZF1; Steroidogenic Factor 1 Nuclear Receptor; Steroidogenic Factor 1; Adrenal 4 Binding Protein; AD4BP; Adrenal 4-Binding Protein; HSF-1; Alternative Protein NR5A1; SF-1; Nuclear Receptor AdBP4; SF1; Steroidogenic Factor-1; FTZ1; SPGF8; ELP; SRXX4; Steroid Hormone Receptor Ad4BP; SRXY3; Fushi Tarazu Factor Homolog 1; POF7; Nuclear Receptor Subfamily 5 Group A Member 1; Nuclear Receptor Subfamily 5, Group A, Member 1
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
