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Results for "

Skeletal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (7) Acetyl-CoA Carboxylase (6) Acyltransferase (1) Adenosine Receptor (3) Adrenergic Receptor (15) Akt (22) Amino Acid Derivatives (1) Aminotransferases (Transaminases) (4) AMPK (9) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (5) Antibody-Oligonucleotide Conjugates (AOCs) (2) Antifolate (1) AP-1 (1) Apoptosis (29) Arp2/3 Complex (1) Arrestin (1) Atg8/LC3 (2) ATP Citrate Lyase (1) Autophagy (7) Bacterial (13) Beclin1 (1) Biochemical Assay Reagents (15) Calcium Channel (14) Carbonic Anhydrase (1) Carnitine Palmitoyltransferase (CPT) (1) Caspase (1) CaSR (2) CDK (1) Ceramidase (1) Chloride Channel (1) Cholinesterase (ChE) (7) COX (1) Creatine Kinase (1) Cytochrome P450 (5) DNA Methyltransferase (1) DNA/RNA Synthesis (7) Drug Derivative (6) Drug Intermediate (6) Drug Metabolite (4) Dystrophin (2) E1/E2/E3 Enzyme (2) Endogenous Metabolite (37) Environmental Pollutants (8) ERK (9) Estrogen Receptor/ERR (1) Exosomes (4) FAK (1) Farnesyl Transferase (1) Ferroptosis (1) FGFR (1) Fluorescent Dye (1) Free Fatty Acid Receptor (1) Fungal (3) Furin (1) FXR (2) GABA Receptor (4) Gap Junction Protein (1) GLUT (7) Glycosidase (2) Guanylate Cyclase (1) Herbicide (2) HMG-CoA Reductase (HMGCR) (1) HSP (1) IFNAR (1) iGluR (4) IKK (2) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (4) Insecticide (1) Insulin Receptor (3) Interleukin Related (6) Isotope-Labeled Compounds (16) JAK (2) JNK (2) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) Liposome (1) LXR (1) mAChR (3) MAP3K (5) MDM-2/p53 (1) MicroRNA (1) Mitochondrial Metabolism (5) Mitophagy (2) MMP (1) Monoamine Oxidase (4) mRNA (1) mTOR (4) Myosin (10) Na+/K+ ATPase (1) nAChR (10) NF-κB (8) NO Synthase (3) Notch (2) Opioid Receptor (1) P2X Receptor (3) P2Y Receptor (2) p38 MAPK (5) p62 (2) PAI-1 (1) Parasite (9) PDHK (2) Peptide-Drug Conjugates (PDCs) (1) PGC-1α (2) Phosphatase (3) Phosphodiesterase (PDE) (3) Phospholipase (2) Phosphoramidites (3) Phosphorylase (3) Phytohormone (1) PI3K (5) PKA (4) PKC (2) Potassium Channel (4) PPAR (4) Proteasome (1) Protoporphyrinogen IX oxidase (2) PTHR (1) Pyk2 (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (3) Reference Standards (39) ROS Kinase (5) Ser/Thr Kinase (1) Ser/Thr Protease (1) Sirtuin (1) Small Interfering RNA (siRNA) (1) SOD (1) Sodium Channel (4) STAT (3) Succinate Dehydrogenase (1) Tau Protein (1) TGF-beta/Smad (1) TGF-β Receptor (3) TNF Receptor (3) Trace Amine-associated Receptor (TAAR) (1) Transferrin Receptor (1) Transmembrane Glycoprotein (1) TRP Channel (3) TSH Receptor (1) Wnt (7) β-catenin (6)
By Research Areas:	Cancer (49) Cardiovascular Disease (32) Endocrinology (14) Infection (28) Inflammation/Immunology (36) Metabolic Disease (95) Neurological Disease (88)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Nucleotide Analogs (3) Adenine (1) Phospholipids (1) Cytosine (1) mRNA (1) Cationic Lipids (1) siRNA drugs (1) Antisense Oligonucleotides (1) Phosphoramidites (3) Guanine (1) siRNAs (1)

262

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium	Exosomes Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

Clenbuterol hydrochloride 5+ Cited Publications NAB-365 hydrochloride	Adrenergic Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

Sevasemten EDG-5506	Myosin	Others
Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models .

Alendronic acid 5+ Cited Publications	NF-κB Interleukin Related	Metabolic Disease
Alendronate acid is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate acid induces skeletal alterations in the chicken embryonic development model. Alendronate acid can be used for osteoporosis research .

L-Alloisoleucine 1 Publications Verification (3R)-LS-Isoleucine	Endogenous Metabolite	Metabolic Disease
L-Alloisoleucine is a stereoisomer of L-isoleucine. L-Alloisoleucine can be used in skeletal muscle research .

Rocuronium Bromide 2 Publications Verification ORG 9426 Bromide	nAChR	Neurological Disease Inflammation/Immunology Cancer
Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.

Alendronate sodium 5+ Cited Publications Alendronic acid monosodium salt	NF-κB Interleukin Related	Metabolic Disease
Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research .

Cyclobenzaprine hydrochloride MK130 hydrochloride	5-HT Receptor Parasite	Infection Neurological Disease
Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT₂ receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases .

(−)-Myrtenal (1R)-(−)-Myrtenal; (−)-(1R,5S)-Myrtenal	Akt	Metabolic Disease Cancer
(-)-Myrtenal ((1R)-(-)-Myrtenal) is an orally active terpene with antitumour activity. (-)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats .

Isovaleric acid 1 Publications Verification	Environmental Pollutants Endogenous Metabolite PKA AMPK	Metabolic Disease
Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders .

BTS 3 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Cardiovascular Disease Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

Reldesemtiv 2 Publications Verification CK-2127107	Calcium Channel	Cardiovascular Disease
Reldesemtiv (CK-2127107) is a selective, orally active and next-generation *fast skeletal* muscle troponin** activator (FSTA). Reldesemtiv selectively activates fast skeletal myofibrils with an EC₅₀ of 3.4 μM. Reldesemtiv increases exercise performance in a heart failure model .

Sabinene 2 Publications Verification	Others	Others
Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways .

L-Norleucine (S)-2-Aminohexanoic acid; (S)-Norleucine	Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

Chlorphenesin carbamate Maolate; U 19646	Drug Derivative	Neurological Disease
Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant, as well as a derivate of Chlorphenesin (HY-A0133). Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation . Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels . Antinociceptive effect .

Mivacurium dichloride	nAChR	Neurological Disease
Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .

TCL053	Liposome	Neurological Disease
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .

PF-4618433 5 Publications Verification	Pyk2	Metabolic Disease
PF-4618433 is a potent and selective PYK2 inhibitor, with an IC₅₀ of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration .

MPH-220 1 Publications Verification	Myosin	Neurological Disease
MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness .

Gallamine Triethiodide	mAChR Adrenergic Receptor	Neurological Disease
Gallamine Triethiodide is a blood-brain barrier-permeable skeletal muscle relaxant. Gallamine Triethiodide induces skeletal muscle paralysis by blocking acetylcholine. Gallamine Triethiodide directly stimulates intracardiac β receptors. Gallamine Triethiodide prolongs the duration of afterdischarge in the cat cerebral cortex. Gallamine Triethiodide can be used in studies related to convulsive disorders .

Tirasemtiv 1 Publications Verification CK-2017357	Biochemical Assay Reagents	Neurological Disease
Tirasemtiv is an activator of the fast skeletal muscle troponin complex. Tirasemtiv is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

(+)-EMD 57033	Phosphodiesterase (PDE)	Cardiovascular Disease
(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca ²⁺ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function .

PKI(5-24) 3 Publications Verification	PKA	Others
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

N-p-trans-Coumaroyltyramine	Cholinesterase (ChE) Parasite Glycosidase	Infection Neurological Disease
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound and an inhibitor of AChE (IC₅₀: 122 μM) and α-glucosidase (IC₅₀: 2.7 μM). N-p-trans-Coumaroyltyramine also has anti-trypanosomal activity, with an IC₅₀ of 13.3 µM against T. brucei rhodesiense. N-p-trans-Coumaroyltyramine can be used in the research of diseases such as Alzheimer's disease .

Pancuronium dibromide	nAChR	Neurological Disease
Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action .

Decamethonium Bromide 1 Publications Verification	nAChR	Neurological Disease
Decamethonium Bromide is an acetylcholine receptor inhibitor and muscle relaxant. Decamethonium Bromide first induces depolarization of skeletal muscles, and then binds to postsynaptic acetylcholine receptors to induce persistent paralysis .\n

2'-Aminoacetophenone o-aminoacetophenone	Bacterial Apoptosis Atg8/LC3 p62 Autophagy	Infection Inflammation/Immunology
2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .

Sodium creatine phosphate dibasic tetrahydrate 3 Publications Verification Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

Chromium chloride		Cardiovascular Disease Metabolic Disease
Chromium chloride is a trivalent chromium compound and an essential trace mineral. Chromium chloride enhances insulin-stimulated GLUT4 translocation and glucose uptake in skeletal muscle. Chromium chloride regulates glucose and lipid metabolism, inhibits TNF-α secretion and oxidative stress in monocytes treated with high glucose or H₂O₂, and reverses hydrogen peroxide-induced cell growth inhibition. Chromium chloride reduces coronary and aortic lipid deposition and serum cholesterol levels in hypercholesterolemic rabbits. Chromium chloride can be used in research related to diabetes and cardiac atherosclerosis .

Calcium gluconate	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology
Calcium gluconate is an orally effective calcium salt supplement . Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury .

NMD670	Chloride Channel	Neurological Disease
NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC₅₀ of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue .

Mephenoxalone	Drug Derivative	Neurological Disease
Mephenoxalone is a muscle relaxant with anti-anxiety activity. Mephenoxalone has neuropharmacologic activity in vivo. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

Panaxatriol 3 Publications Verification	Others Insulin Receptor	Cardiovascular Disease Others Metabolic Disease Cancer
Panaxatriol is an orally active insulin sensitizer. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular ROS levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer .

5α-Cholestane	Biochemical Assay Reagents Drug Intermediate	Metabolic Disease
5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research .

Metronidazole hydrochloride 60+ Cited Publications SC 326421	Antibiotic Bacterial Parasite Apoptosis	Infection Inflammation/Immunology Cancer
Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application .

MuRF1-IN-2	Bacterial E1/E2/E3 Enzyme	Inflammation/Immunology
MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy .

(±)-Hexanoylcarnitine chloride DL-Hexanoylcarnitine chloride	Endogenous Metabolite	Metabolic Disease
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways .

Poloxamer L61	Biochemical Assay Reagents	Others
Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production .

Antidiabetic agent 6	GLUT Akt	Metabolic Disease
Antidiabetic agent 6 (Compound 19) is an antidiabetic Agent. Antidiabetic agent 6 stimulates GLUT4 translocation by activation of the PI3K/AKT-dependent signaling pathway. Antidiabetic agent 6 reduces blood glucose levels in Streptozotocin (HY-13753)-induced diabetic rats .

TG693	CDK Dystrophin	Others
TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research .

Mephenesin	iGluR	Neurological Disease
Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .

2'-Aminoacetophenone (Standard) o-aminoacetophenone (Standard)	Reference Standards Bacterial Apoptosis Atg8/LC3 p62 Autophagy	Infection Inflammation/Immunology
2'-Aminoacetophenone (Standard) is the analytical standard of 2'-Aminoacetophenone. This product is intended for research and analytical applications. 2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .

Decarbamoylsaxitoxin DcSTX; DecarbamoylSTX	Endogenous Metabolite Drug Metabolite	Neurological Disease
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na ⁺ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .

(S)-β-Aminoisobutyric acid hydrochloride 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
(S)-β-Aminoisobutyric acid hydrochloride is a cytoprotective agent, which is a non-proteinogenic amino acid enantiomer derived from valine metabolism in skeletal muscle mitochondria. The plasma level of (S)-β-Aminoisobutyric acid hydrochloride increases significantly after acute aerobic exercise (and is not affected by the AGXT2 rs37369 genotype), and it is secreted by mouse extensor digitorum longus and soleus muscles in ex vivo contraction assays. (S)-β-Aminoisobutyric acid hydrochloride specifically protects osteocytes from oxidative stress-induced cell death .

L-Norleucine (Standard) (S)-2-Aminohexanoic acid (Standard); (S)-Norleucine (Standard)	Reference Standards Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine (Standard) is the analytical standard of L-Norleucine. This product is intended for research and analytical applications. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

Cat. No.	Product Name	Type

HY-147332

TCL053	Biochemical Assay Reagents
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .

HY-W011012

Adenosine 5'-monophosphate disodium

15+ Cited Publications

Biochemical Assay Reagents

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W145486

Calcium gluconate

Biochemical Assay Reagents

Calcium gluconate is an orally effective calcium salt supplement . Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury .

HY-W008951

Ethylenediaminetetra(methylenephosphonic acid)

EDTMP

Biochemical Assay Reagents

Ethylenediaminetetramethylenephosphonic acid (EDTMP) is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with ¹⁵³Sm and ¹⁷⁷Lu. Ethylenediaminetetramethylenephosphonic acid is used to study palliative therapy for pain associated with multiple bone metastatic cancers .

HY-133970

5α-Cholestane	Biochemical Assay Reagents
5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research .

HY-77785

2-Amino-5-chlorobenzophenone 1 Publications Verification 5-Chloro-2-aminobenzophenone	Biochemical Assay Reagents
2-Amino-5-chlorobenzophenone (5-Chloro-2-aminobenzophenone) is a chemical intermediate. Derivatives of 2-Amino-5-chlorobenzophenone serve as skeletal muscle relaxants. 2-Amino-5-chlorobenzophenone acts as a starting material for the synthesis of anti-biofilm 2-amino-5-chlorobenzophenone Schiff bases. 2-Amino-5-chlorobenzophenone is applicable to research related to bacterial infections .\n

HY-D1005I

Poloxamer L61

Biochemical Assay Reagents

Poloxamer L61 is a non-ionic triblock copolymer surfactant. Poloxamer L61 effectively achieves intracellular molecular delivery to cancer cells during photoacoustic molecular delivery, and maintains cell viability by promoting cell membrane resealing, thus avoiding irreversible damage caused by laser-induced membrane permeabilization. Poloxamer L61 is a key component of SP1017, a compound related to gene therapy, which regulates the interaction between DNA and extracellular matrix as well as cellular uptake, and significantly enhances the distribution and bioavailability of plasmid DNA in skeletal muscle. Poloxamer L61 can be used in studies on local or systemic therapeutic protein production .

HY-133970R

5α-Cholestane (Standard)	Biochemical Assay Reagents
5α-Cholestane (Standard) is the analytical standard of 5α-Cholestane (HY-133970). This product is intended for research and analytical applications. 5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research .

HY-W127670

Decamethonium iodide

Biochemical Assay Reagents

Decamethonium (iodide) is an organic compound containing ammonium and iodide ions. It is commonly used as a neuromuscular blocking agent in anesthesia to induce muscle relaxation during surgery. Decamethonium Iodide acts by binding to nicotinic acetylcholine receptors (nAChRs) in the neuromuscular junction, causing depolarization block and subsequent skeletal muscle paralysis. In addition, it can also serve as a reference standard for pharmacological studies of nAChRs.

HY-77785R

2-Amino-5-chlorobenzophenone (Standard) 5-Chloro-2-aminobenzophenone (Standard)	Biochemical Assay Reagents
2-Amino-5-chlorobenzophenone (Standard) is the analytical standard of 2-Amino-5-chlorobenzophenone. This product is intended for research and analytical applications. 2-Amino-5-chlorobenzophenone is a substituted benzophenone and can be used in the synthesis of benzodiazepines. The 2-Amino-5-chlorobenzophenone derivative has skeletal muscle relaxation activity.

HY-W011012R

Adenosine 5'-monophosphate disodium (Standard)

Biochemical Assay Reagents

Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

Cat. No.	Product Name	Target	Research Area

HY-P0222

PKI(5-24) 3 Publications Verification	PKA	Others
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P2048A

MOTS-c(human) acetate 1 Publications Verification	AMPK GLUT	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
MOTS-c (human) acetate is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

HY-P10643

Skeletal muscle-targeted peptide MSP	Peptides	Infection
Skeletal muscle-targeted peptide MSP is a 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP). Skeletal muscle-targeted peptide MSP can target the virus through a different binding ligand to the muscle. Skeletal muscle-targeted peptide MSP can be used for the research of diseases of the heart and skeletal muscles .

HY-114883

Homocarnosine L-Homocarnosine	GABA Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-16498

Tigapotide PCK-3145	Apoptosis PTHR	Metabolic Disease Cancer
Tigapotide (PCK-3145) is a synthetic 15-mer peptide derived from prostate-secretory protein, and acts as an antineoplastic agent. Tigapotide inhibits tumor growth, experimental bone metastasis, and malignancy-associated hypocalcemia. Tigapotide induces apoptosis in prostate cancer cells and tumors, and suppresses the growth of prostate cancer cells. Tigapotide inhibits the production of parathyroid hormone-related protein (PTHrP) in tumors and plasma. Tigapotide reduces plasma calcium levels in hypercalcemic tumor-bearing rats. Tigapotide is applicable for the research of prostate cancer and malignancy-associated hypercalcemia .

HY-P4580

Suc-Ala-Ala-Pro-Phe-SBzl	Proteasome	Others
Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .

HY-P6013A

wt hMLN TFA	Calcium Channel	Others
wt hMLN (TFA) is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-P10870

Pep1-DNP conjugate 9	Peptide-Drug Conjugates (PDCs) FGFR Apoptosis	Cancer
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with K_D of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models .

HY-P6013

wt hMLN	Calcium Channel	Others
wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-P0222A

PKI(5-24) TFA	PKA	Others
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P11684

Fmoc-PNA-C(Boc)-OH	DNA/RNA Synthesis	Others
Fmoc-PNA-C(Boc)-OH is a protected peptide nucleic acid (PNA) monomer for solid-phase synthesis. Fmoc-PNA-C(Boc)-OH possesses Fmoc-protected skeletal amino groups and Boc-protected cytosine bases, designed to construct stable synthetic DNA analogs. Fmoc-PNA-C(Boc)-OH can be used to prepare highly specific, enzyme-stable antisense probes and diagnostic probes.

HY-P11741

BV2	Exosomes Biochemical Assay Reagents	Neurological Disease
BV2 is a delivery peptide that binds to BVES, with a K_a of 2.03 μM for the BVES target. BV2 specifically binds to the extracellular domain of BVES, achieving muscle homing and cellular internalization via caveolae-mediated endocytosis. When BV2 is modified on the surface of exosomes by PMO, it enhances dystrophin restoration in the peripheral muscles and myocardium of dystrophin-deficient mice. BV2 is applicable to research related to Duchenne muscular dystrophy and muscle atrophy .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99388

Trevogrumab 1 Publications Verification REGN-1033; SAR391786	TGF-beta/Smad	Metabolic Disease
Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake .

HY-P992223

Anti-DAG1/Dystroglycan Antibody (DAG-6F4)	Transmembrane Glycoprotein	Neurological Disease
Anti-DAG1/Dystroglycan Antibody (DAG-6F4) is a human monoclonal antibody against DAG1/Dystroglycan. Anti-DAG1/Dystroglycan Antibody (DAG-6F4) can bind specifically to the α and β subunits of the dystroglycan protein complex. Anti-DAG1/Dystroglycan Antibody (DAG-6F4) is applicable to research related to muscular dystrophy .

Species:	Human (6) Mouse (3)
Tag:	SUMO (1) His (8) Myc (1) GST (1)
Source:	E. coli Cell-free (3) Sf9 insect cells (1) P. pastoris (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75732

	Enolase 3/ENO3 Protein, Human (His) Beta-enolase; Enolase 3; MSE; Skeletal muscle enolase	Human	E. coli
	Enolase 3/ENO3 protein acts as a glycolytic enzyme, promoting the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In addition to its role in glycolysis, ENO3 appears to play a crucial role in the development and regeneration of striated muscle. Enolase 3/ENO3 Protein, Human (His) is the recombinant human-derived Enolase 3/ENO3 protein, expressed by E. coli , with N-His labeled tag.

HY-P72273

	MUSK Protein, Human (P.pastoris, His) Muscle, Skeletal receptor tyrosine-protein kinase; CMS9; FADS; MDK4; Muscle; MuSK;	Human	P. pastoris
	MUSK protein is a receptor tyrosine kinase that plays a crucial role in the formation and maintenance of the neuromuscular junction (NMJ). After LRP4 recruits AGRIN, MUSK phosphorylates and activates, affecting gene expression, coordinating actin cytoskeletal reorganization, and clustering acetylcholine receptors (AChR) in the postsynaptic membrane. MUSK Protein, Human (P.pastoris, His) is the recombinant human-derived MUSK protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P705537

	CACNG1 Protein, Human (Cell-Free, His) Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, Skeletal muscle calcium channel subunit gamma	Human	E. coli Cell-free

HY-P705529

	ENO3 Protein, Mouse (P. pastoris, His) Beta-enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 3; Muscle-specific enolase (MSE); Skeletal muscle enolase	Mouse	P. pastoris

HY-P71568

	MUSK Protein, Mouse (Myc, His-SUMO) Musk; Nsk2; Muscle; Skeletal receptor tyrosine-protein kinase; EC 2.7.10.1; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor	Mouse	E. coli
	MUSK protein is a receptor tyrosine kinase that plays a critical role in the formation of the neuromuscular junction (NMJ).MUSK is activated by the AGRIN-LRP4 complex and regulates the NMJ through gene expression, actin cytoskeleton reorganization, and acetylcholine receptor (AChR) clustering.MUSK Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived MUSK protein, expressed by E.coli , with C-Myc, N-SUMO, N-10*His labeled tag.

HY-P702578

	Sialidase-2 Protein, Mouse (P.pastoris, His) Neu2; Sialidase-2; EC 3.2.1.18; Cytosolic sialidase; Mouse Skeletal muscle sialidase; MSS; Murine thymic sialidase; MTS; N-acetyl-alpha-neuraminidase 2	Mouse	P. pastoris
	Sialidase-2 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Sialidase-2, expressed by P. pastoris , with N-10*His labeled tag. ,

HY-P704183

	ATP2A1 Protein, Human (Cell-Free, His) SERCA1; SR Ca2+; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch Skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca2+	Human	E. coli Cell-free
	ATP2A1 is critical for striated muscle function, acting as the primary Ca(2+) ATPase to efficiently reuptake cytosolic Ca(2+) into the sarcoplasmic reticulum. Through ATP hydrolysis, ATP2A1 transfers calcium from the cytoplasm to the sarcoplasmic reticulum lumen, which is critical for precise control of calcium levels, regulation of isolation, and control of muscle excitation and contraction dynamics. ATP2A1 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP2A1 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.

HY-P704169

	SLC25A4 Protein, Human (His) ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/Skeletal muscle isoform T1; Adenine nucleotide translocator 1; Solute carrier family 25 member 4	Human	E. coli Cell-free
	SLC25A4 Protein, Human (His) is the recombinant human-derived SLC25A4 protein, expressed by E. coli cell-free system, with N-10*His tag.

HY-P702665

	PHKG1 Protein, Human (Active, sf9, GST) PHKG1; phosphorylase kinase, gamma 1 (muscle); phosphorylase kinase, gamma 1 (muscle); phosphorylase b kinase gamma catalytic chain, Skeletal muscle isoform; phosphorylase kinase gamma; phosphorylase kinase subunit gamma-1; EC 2.7.11.19	Human	Sf9 insect cells
	PHKG1 is the catalytic subunit of phosphorylase b kinase (PHK), which plays a key role in the neural and hormonal regulation of glycogenolysis (glycogen breakdown) by phosphorylating and activating glycogen phosphorylase. PHKG1 Protein, Human (Active, sf9, GST) is the recombinant human-derived PHKG1, expressed by Sf9 insect cells, with GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-113354S

Anserine-d4
Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-B0194S

Tizanidine-d4

Tizanidine-d₄ is the deuterium labeled Tizanidine (HY-B0194). Tizanidine, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-Y0017S

L-Norleucine-d9
L-Norleucine-d₉ is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-W011012S

Adenosine 5'-monophosphate-13C disodium

Adenosine 5'-monophosphate- ¹³C (disodium) is a ¹³C-labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-Y1322S

Triphenyl phosphate-d15

Triphenyl phosphate-d₁₅ is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.

HY-B0740S

Cyclobenzaprine-d3 hydrochloride
Cyclobenzaprine-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-115766S

Anabaseine-d4
Anabaseine-d₄ is the deuterium labeled Anabaseine (HY-115766). Anabaseine is a non-selective nicotinic agonist. Anabaseine stimulates all AChRs, preferentially stimulates skeletal muscle and brain α7 subtypes . Anabaseine is also a weak partial agonist at α4β2 nAChRs .

HY-B1901S

Eperisone-d10 hydrochloride

Eperisone-d₁₀ (hydrochloride) is the deuterium labeled Eperisone hydrochloride. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect [2 .

HY-B1283S

Mephenesin-d3
Mephenesin-d₃ is deuterium labeled Mephenesin. Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .

HY-B0740S3

Cyclobenzaprine-d3-1 hydrochloride

Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT₂ receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases

HY-133970S

5α-Cholestane-d6
5α-Cholestane-d₆ is the deuterium labeled 5α-Cholestane (HY-133970). 5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research .

HY-133970S1

5α-Cholestane-d2
5α-Cholestane-d₂ is the deuterium labeled 5α-Cholestane (HY-133970). 5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research .

HY-113354S1

Anserine-d4 hydrochloride

Anserine-d₄ hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-B1343AS

Pridinol-d5

Pridinol-d₅ is deuterium labeled Pridinol (HY-B1343A) . Pridinol is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-W011012S1

Adenosine 5'-monophosphate-d2 disodium

Adenosine 5'-monophosphate-d₂ disodium is the deuterium labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-B0194AS

Tizanidine-d4 hydrochloride

Tizanidine-d₄ hydrochloride is deuterium labeled Tizanidine hydrochloride (HY-B0194A). Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-W751350

Cyclobenzaprine-d6

Cyclobenzaprine-d₆ is the deuterium labeled Cyclobenzaprine. Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT₂ receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases .

Host:	Mouse (6) Rabbit (13)
Reactivity:	Human (18) Bovine (1) Rat (15) Mouse (12) Monkey (1) Bovin (1) Zebrafish (1) Chicken (1) Chick (1) Dog (1) Pig (2)
Application:	IHC-P (16) ICC/IF (11) IF-Tissue (2) IP (5) IHC-F (6) WB (14) ELISA (4)
Isotype:	IgG (13) IgG1 (3) IgG/Kappa (1)
Conjugation:	Non-conjugated (19)
Clonality:	Monoclonal (15) Recombinant (9)
Modification:	Unmodified (15)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81258

	*alpha Skeletal* Muscle Actin Antibody (YA930)** ACTA1; ACTA; Actin; alpha Skeletal muscle; Alpha-actin-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	alpha Skeletal Muscle Actin Antibody (YA930) is a mouse-derived non-conjugated IgG monoclonal antibody (Clone NO.: YA930), targeting alpha Skeletal Muscle Actin. It can be used as a loading control antibody.

HY-P81258A

	*alpha Skeletal* Muscle Actin Antibody (YA931)** ACTA1; ACTA; Actin; alpha Skeletal muscle; Alpha-actin-1	IHC-P	Human
	alpha Skeletal Muscle Actin Antibody (YA931) is a rabbit-derived non-conjugated IgG monoclonal antibody (Clone NO.: YA931), targeting alpha Skeletal Muscle Actin. It can be used as a loading control antibody.

HY-P85681

	*alpha Skeletal* Muscle Actin Antibody (YA5373)** ACTA1; ACTA; Actin, alpha Skeletal muscle; Alpha-actin-1	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	alpha Skeletal Muscle Actin Antibody (YA5373) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to alpha Skeletal Muscle Actin.

HY-P81258AA

	*alpha Skeletal* Muscle Actin Antibody (YA931)(PBS only)** ACTA1; ACTA; Actin; alpha Skeletal muscle; Alpha-actin-1	IHC-P	Human
	alpha Skeletal Muscle Actin Antibody (YA931) is a rabbit-derived non-conjugated IgG monoclonal antibody (Clone NO.: YA931), targeting alpha Skeletal Muscle Actin. It can be used as a loading control antibody.

HY-P82087

	Troponin I Antibody (YA1832) TNNI2; Troponin I; fast Skeletal muscle; Troponin I; fast-twitch isoform	WB, IP	Human, Mouse, Rat
	Troponin I Antibody (YA1832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Troponin I.

HY-P85399

	Troponin I-FS Antibody (YA5091) TNNI2; Troponin I; fast Skeletal muscle; Troponin I, fast-twitch isoform	WB, IP	Human, Mouse, Rat
	Troponin I-FS Antibody (YA5091) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Troponin I-FS.

HY-P85288

	MuSK Antibody (YA4980) MUSK; Muscle; Skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor	IHC-P, ICC/IF, ELISA	Human
	MuSK Antibody (YA4980) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MuSK.

HY-P85288A

	MuSK Antibody (YA4980)(PBS only) MUSK; Muscle; Skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor	IHC-P, ICC/IF, ELISA	Human
	MuSK Antibody (YA4980) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MuSK.

HY-P82252

	ACTN3 Antibody (YA1997) ACTN3; Alpha-actinin-3; Alpha-actinin Skeletal muscle isoform 3; F-actin cross-linking protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	ACTN3 Antibody (YA1997) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ACTN3.

HY-P83782

	*Fast Myosin Skeletal* Heavy chain Antibody(YA3479)** adult 1 antibody; MYH1 antibody; MYH1_HUMAN antibody; MyHC-2x antibody; MyHC-IIx/d antibody; Myosin heavy chain 1 antibody; Myosin heavy chain 2x antibody; Myosin heavy chain antibody; Myosin heavy chain IIx/d antibody; Myosin-1 antibody; Skeletal muscle antibody	IHC-P, IF-Tissue	Human, Mouse, Rat
	Fast Myosin Skeletal Heavy chain Antibody(YA3479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fast Myosin Skeletal Heavy chain.

HY-P86079

	Sarcomeric alpha Actinin Antibody (YA5771) ACTN2; Alpha-actinin-2; Alpha-actinin Skeletal muscle isoform 2; F-actin cross-linking protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Sarcomeric alpha Actinin Antibody (YA5771) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sarcomeric alpha Actinin.

HY-P85415

	Sarcomeric alpha Actinin Antibody (YA5107) ACTN2; Alpha-actinin-2; Alpha-actinin Skeletal muscle isoform 2; F-actin cross-linking protein	WB, ICC/IF	Human, Rat, Bovine, Chicken, Dog, Pig, Zebrafish
	Sarcomeric alpha Actinin Antibody (YA5107) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Sarcomeric alpha Actinin.

HY-P82252A

	ACTN3 Antibody (YA1997)(PBS only) ACTN3; Alpha-actinin-3; Alpha-actinin Skeletal muscle isoform 3; F-actin cross-linking protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	ACTN3 Antibody (YA1997) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ACTN3.

HY-P85828

	Actin Muscle Specific Antibody (YA5520) Actin, alpha cardiac muscle 1; Alpha-cardiac actin; Actin, alpha Skeletal muscle; Alpha-actin-1; Actin, gamma-enteric smooth muscle; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey, Bovin, Pig, Chick
	Actin Muscle Specific Antibody (YA5520) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Actin Muscle Specific.

HY-P86969

	MYH2 Antibody (YA6662) adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; MyHC-IIa antibody; MYHSA2 antibody; Myosin heavy chain 2 antibody; Myosin heavy chain 2a antibody; Myosin heavy chain antibody; Myosin heavy chain IIa antibody; Myosin heavy chain Skeletal muscle adult 2 antibody; Myosin heavy polypeptide 2 Skeletal muscle adult antibody; Myosin-2 antibody; MYPOP antibody; Skeletal muscle antibody; Type IIA myosin heavy chain antibody;	WB, IHC-P	Human, Mouse, Rat
	MYH2 Antibody (YA6662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH2.

HY-P82186

	SERCA2 ATPase Antibody (YA1931) ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch Skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SERCA2 ATPase.

HY-P82186A

	SERCA2 ATPase Antibody (YA1931)(PBS only) ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch Skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SERCA2 ATPase.

HY-P87094

	*Slow Skeletal* Myosin Heavy chain Antibody (YA6787)** Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; MYHCB antibody; Myopathy, distal 1 antibody; Myosin heavy chain (AA 1-96) antibody; Myosin heavy chain 7 antibody; Myosin heavy chain antibody; Myosin heavy chain slow isoform antibody; Myosin heavy chain, cardiac muscle beta isoform antibody; Myosin, heavy chain 7, cardiac muscle, beta antibody; Myosin, heavy polypeptide 7, cardiac muscle, beta antibody; Myosin-7 antibody; Rhabdomyosarcoma antigen MU RMS 40.7A antibody; SPMD antibody; SPMM antibody;	WB, IHC-P, IF-Tissue, IHC-F	Human, Mouse, Rat
	Slow Skeletal Myosin Heavy chain Antibody (YA6787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Slow Skeletal Myosin Heavy chain.

HY-P86873

	FABP3 Antibody (YA6566) 422 protein antibody; Cardiac Fatty Acid Binding Protein antibody; FABP 11 antibody; FABP 3 antibody; FABP11 antibody; FABP3 antibody; FABPH_HUMAN antibody; Fatty acid binding protein 11 antibody; Fatty acid binding protein 3 antibody; Fatty acid binding protein 3 muscle and heart antibody; 422 protein antibody; Cardiac Fatty Acid Binding Protein antibody; FABP 11 antibody; FABP 3 antibody; FABP11 antibody; FABP3 antibody; FABPH_HUMAN antibody; Fatty acid binding protein 11 antibody; Fatty acid binding protein 3 antibody; Fatty acid binding protein 3 muscle and heart antibody; Fatty acid binding protein 3 muscle and heart mammary derived growth inhibitor antibody; Fatty acid binding protein 3 muscle antibody; Fatty acid binding protein 3, muscle and heart (mammary derived growth inhibitor) antibody; Fatty acid binding protein 3, muscle antibody; Fatty acid binding protein heart antibody; Fatty acid binding protein, heart antibody; Fatty acid binding protein, muscle and heart antibody; Fatty acid binding protein, Skeletal muscle antibody; Fatty acid-binding protein 3 antibody; Fatty acid-binding protein antibody; H FABP antibody; H-FABP antibody; heart antibody; Heart type fatty acid binding protein antibody; Heart-type fatty acid-binding protein antibody; M FABP antibody; M-FABP antibody; Mammary derived growth inhibitor antibody; Mammary-derived growth inhibitor antibody; MDGI antibody; Muscle fatty acid binding protein antibody; Muscle fatty acid-binding protein antibody; Mylein protein P2 homolog antibody; O FABP antibody; OTTHUMP00000003898 antibody; P2 adopocyte protein antibody;	WB, IHC-P	Mouse, Rat
	FABP3 Antibody (YA6566) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FABP3.

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Cat. No.	Product Name		Classification

HY-15964

Tirasemtiv 1 Publications Verification CK-2017357		Alkynes
Tirasemtiv is an activator of the fast skeletal muscle troponin complex. Tirasemtiv is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-W010737

Guanosine-5'-triphosphate disodium salt Maximum Cited Publications 8 Publications Verification 5'-GTP disodium salt		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-12695

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-147332

TCL053		Cationic Lipids
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .

HY-12695B

Guanosine 5'-triphosphate trisodium salt hydrate Maximum Cited Publications 8 Publications Verification 5'-GTP trisodium salt hydrate		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-145725A

Baliforsen ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx		Antisense Oligonucleotides
Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits DMPK mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 .

HY-148009

Cardiolipin (16:0/18:1/16:0/18:1) sodium 16:0-18:1 Cardiolipin sodium		Phospholipids
Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H₂O fragment formation and (DG-H₂O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .

HY-164583

DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite		Phosphoramidites Adenine
DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite allows site-specific introduction of a 2'-O-C22 lipophilic modification at adenosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-164582

DMTr-2'-O-C22-rC(Ac)-3'-CE-Phosphoramidite		Phosphoramidites Cytosine
DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at cytidine positions during oligonucleotide synthesis, which is used to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. Construction and mechanism study of DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite nucleic acid silencing molecules .

HY-164581

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite		Phosphoramidites Guanine
DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-174554

Human PAX9 mRNA		mRNA
Human PAX9 mRNA encodes the human paired box 9 (PAX9) protein, a member of the paired box (PAX) family. PAX9 is required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

HY-147262

Etedesiran		siRNAs siRNA drugs
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .

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