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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
140 Results for "
acetylated
" in MedChemExpress (MCE) Product Catalog:
Products (140)
140 Results for "acetylated" in MCE Product Catalog:
24
24 Publications Verification
Synonyms: GSK 525762C; I-BET 762 besylate
Target:
연구분야:
Molibresib besylate (GSK 525762C; I-BET 762 besylate) is an orally active pan-BET inhibitor that targets and binds to BRD2, BRD3, BRD4 and BRDT. By competitively occupying acetylated lysine binding sites, Molibresib besylate disrupts the interaction between BET proteins and chromatin, thereby effectively inhibiting MYC expression and target gene transcription. Molibresib besylate exhibits broad antiproliferative activity, which not only inhibits cancer cell growth and induces growth arrest, but also downregulates mitosis-related genes and upregulates the level of p-ERK1/2. When combined with MEK inhibitors, Molibresib besylate shows a significant synergistic effect, reduces tumor burden in mouse models of leukemia, modulates the immune microenvironment and prolongs survival. Molibresib besylate is widely applicable to research related to acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer and various advanced refractory solid tumors .
4
4 Cited Publications
Cat. No.: HY-P2161B
Target:
연구분야:
2
2 Cited Publications
Cat. No.: HY-16531
CAS No.: 1311423-89-8
Target:
연구분야:
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease .
2
2 Cited Publications
Cat. No.: HY-N0912
CAS No.: 81720-08-3
2
2 Cited Publications
Cat. No.: HY-16531A
CAS No.: 1312005-62-1
Target:
연구분야:
YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease .
1
Target:
1
1 Cited Publications
Cat. No.: HY-W048838
CAS No.: 1946-82-3
Target:
1
1 Cited Publications
Cat. No.: HY-N1410
CAS No.: 42206-94-0
1
1
1
1 Cited Publications
Synonyms: ILS-JGB-1741
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research .
1
1 Cited Publications
Cat. No.: HY-P76782
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MSR1; Macrophage acetylated LDL Receptor I And II; Macrophage Scavenger Receptor 1; Scavenger Receptor Class A Member 1; SCARA1; CDNA FLJ55770, Highly Similar To Macrophage Scavenger Receptor Types I And II; SR-AIII; Macrophage Scavenger Receptor Type III
Species:
Mouse
Source:
HEK293
Synonyms: Monoacetylcadaverine
Target:
Synonyms: BI894999
Target:
연구분야:
Amredobresib (BI894999) is an orally active BET inhibitor. Amredobresib inhibits the binding of BRD4-BD1 and BRD4-BD2 bromodomains to acetylated histones with IC50 values of 5 nM and 41 nM, respectively. Amredobresib exhibits anticancer activity against acute myeloid leukemia (AML) and NUT cancer .
Target:
연구분야:
BRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor with an IC50 of 8 nM. BRD4 Inhibitor-10 interferes with the recognition of acetylated histone marks by the BRD4 bromodomain through inhibiting the interaction between BRD4-BD1 and tetra-acetylated histone H4 peptide. BRD4 Inhibitor-10 is used for research on BRD4-mediated epigenetic regulation and cancer .
Cat. No.: HY-P5544
CAS No.: 60230-21-9
Synonyms: N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid
Target:
연구분야:
Cat. No.: HY-W004114
CAS No.: 68-95-1
Target:
Target:
연구분야:
Sodium 4-pentynoate is a alkynylacetate analogue, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types . Sodium 4-pentynoate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-W039943
CAS No.: 121584-52-9
Target:
Acetyl-cyclosporin A aldehyde is an acetylated derivative of Cyclosporin A (HY-B0579) with a reducible aldehyde group. Acetyl-cyclosporin A aldehyde serves as a synthetic intermediate for the calcineurin inhibitor Voclosporin (HY-106638). Acetyl-cyclosporin A aldehyde can act as a substrate for ruthenium nanocatalyzed reductive deuteration reactions, producing the corresponding deuterated alcohol with selective deuterium incorporation at the α-position of the oxygen atom .
연구분야:
Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
