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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
acidic lysosomes
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "acidic lysosomes" in MCE Product Catalog:
3
3 Cited Publications
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Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .
3
3 Cited Publications
Cat. No.: HY-D1296
CAS No.: 220524-71-0
2
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Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity .
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1 Cited Publications
Cat. No.: HY-D1445
1
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18:1 BMP (S,S) ammonium (18:1 LBPA (S,S)) is a monounsaturated fatty acid phospholipid. 18:1 BMP (S,S) ammonium reduces lysosomal lipid peroxidation and inhibits the ionizing radiation-induced elevation of intracellular labile ferrous ion (Fe 2+) levels. 18:1 BMP (S,S) ammonium can be used in studies related to ionizing radiation-induced intestinal injury .
Cat. No.: HY-103317A
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NAADP tetrasodium is a second messenger. NAADP tetrasodium releases Ca 2+ from acidic endosomes and lysosomes. NAADP tetrasodium can be used to study cancer (such as oral squamous cell carcinoma, malignant melanoma) and angiogenesis-related diseases .
Cat. No.: HY-14929
CAS No.: 108147-54-2
Synonyms: GR181413A free base; 1-Deoxygalactonojirimycin
Target:
Research Areas:
Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity .
Cat. No.: HY-N16306
CAS No.: 3091879-73-8
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Target:
Cat. No.: HY-108828
CAS No.: 420784-05-0
Synonyms: rhGAA
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Alglucosidase alfa (rhGAA) is a recombinant human acid α-glucosidase. Alglucosidase alfa is taken up by cells via the cation-independent mannose-6-phosphate receptor (CI-MPR) pathway and transported to lysosomes, where GAA degrades glycogen in the acidic lysosomal environment. Alglucosidase alfa is applicable to research related to lysosomal glycogen metabolism and glycogen storage diseases .
Cat. No.: HY-W728096
Synonyms: GR181413A-d5 free base
Cat. No.: HY-W740650
CAS No.: 1219134-37-8
Synonyms: GR181413A-15N
Cat. No.: HY-D3131
CAS No.: 2243068-74-6
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Lyso-MPCB is a two-photon fluorescent probe used for lysosomal pH detection and autophagy monitoring. Lyso-MPCB integrates a benzimidazole pH-responsive group and a morpholine lysosome-targeting group, enabling specific localization to lysosomes. The fluorescence properties of Lyso-MPCB change with protonation, exhibiting blue fluorescence under alkaline conditions and green fluorescence under acidic conditions .
Cat. No.: HY-W339816
CAS No.: 325466-03-3
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(S,R)-Bis(monomyristoylglycero)phosphate ammonium actively contributes to cargo sorting by promoting the degradation and sorting of lipids, and it plays a critical role in the sorting of polyunsaturated fatty acids (PUFAs) within acidic organelles. This phospholipid features two phosphate-linked glycerol molecules arranged in a unique sn-1 glycerophospho-sn-1′ glycerol stereoconformation, with each glycerol molecule esterified to a myristic acid. Typically, it is found in the intraluminal vesicles (ILVs) of late endosomes and lysosomes.
Cat. No.: HY-DY1082
CAS No.: 220524-71-0
Solvent and concentration: DMSO: 2 mM
Cat. No.: HY-14929S
Synonyms: GR181413A-d2
Cat. No.: HY-D2998
CAS No.: 2567068-39-5
Cat. No.: HY-D3163
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Endo-pH is a cell-permeable, pH-responsive fluorescent probe based on BODIPY, with a pKa of 5.08. When pH decreases from 7.32 to 4.97, Endo-pH undergoes protonation under acidic conditions, resulting in a 79-fold increase in fluorescence intensity at 786 nm. The detection wavelengths of its protonated form are Ex/Em=688/786 nm, while the absorption wavelength of its non-protonated form is 745 nm. Endo-pH can be used for staining late endosomes in live cells and determining the fusion time of late endosomes and lysosomes .
Cat. No.: HY-D3207
CAS No.: 3037311-41-1
Cat. No.: HY-D3097
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Lyso-VR1 is a fluorescent probe for lysosomal viscosity detection. The detection mechanism of Lyso-VR1 relies on intramolecular rotation restriction. Due to the protonation of its indole moiety in lysosomes, this probe can specifically target lysosomes, thereby localizing to this suborganelle for viscosity monitoring. Its excitation wavelength ranges from 400-500 nm, and its emission peak under excitation at 488 nm is located at ~550 nm to ~560 nm .
Cat. No.: HY-184404
CAS No.: 71357-99-8
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(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine lipid with palmitoyl fatty acid chains. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine serves as a substrate for glycosylation reactions and a component of biocompatible pH-sensitive hydrophobic copolymer nanoparticles. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine exhibits pH-sensitive drug release properties, enabling faster drug release in acidic environments. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine can be used in studies related to cancer drug delivery .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
