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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
147 Results for "
camptothecin
" in MedChemExpress (MCE) Product Catalog:
Products (147)
147 Results for "camptothecin" in MCE Product Catalog:
75
75 Publications Verification
Synonyms: Campathecin; (S)-(+)-camptothecin; CPT
2
2 Cited Publications
Synonyms: 10,11-(Methylenedioxy)-20(S)-camptothecin
FL118 (10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin (HY-16560) analogue, is a potent and orally active survivin inhibitor. FL118 binds to oncoprotein DDX5 (p68) to dephosphorylates and degrades DDX5. FL118 can be used for the research of cancer .
2
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Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
2
2 Cited Publications
Synonyms: CKD-602 free base
Target:
Domaines de recherche:
Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer .
2
2 Cited Publications
Cat. No.: HY-16228
CAS No.: 529488-28-6
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Genz-644282 is a non-camptothecin topoisomerase I inhibitor, used for cancer research.
1
1 Cited Publications
Synonyms: 9-Amino-20(S)-camptothecin; 9-Amino-CPT
Category:
Nyssaceae Extract Alkaloids Camptotheca acuminata Decne. Plants Disease Research Fields Cancer Indole Alkaloids
Target:
1
1 Cited Publications
Cat. No.: HY-139909A
Pureté: 99.51%
Target:
Domaines de recherche:
CL2E-SN-38 TFA, a highly releasable and structurally stable antibody-SN-38-conjugate, is a part of the antibody drug conjugate (ADC). SN-38, the active metabolite of Irinotecan from camptothecins, is an Topoisomerase I inhibitor .
1
1 Cited Publications
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DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype .
1
1 Cited Publications
Cat. No.: HY-W040129
CAS No.: 7059-24-7
Category:
Cat. No.: HY-W018864
CAS No.: 51364-51-3
Target:
Domaines de recherche:
Tris(dibenzylideneacetonyl)bis-palladium is a catalyst that catalyzes the coupling reaction of N-methyl-2-pyrrolidinone (NMP). Tris(dibenzylideneacetonyl)bis-palladium participates in the synthesis of camptothecin derivatives, 5-HT antagonists, etc .
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7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs) .
Synonyms: KL610023
Target:
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T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .
Domaines de recherche:
MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells .
Cat. No.: HY-B0063
CAS No.: 292618-32-7
Synonyms: ST1481
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Domaines de recherche:
Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity .
Synonyms: RFS 2000; 9-Nitrocamptothecin
Category:
Nyssaceae Extract Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Disease Research Fields Cancer
Target:
Synonyms: 7-Hydroxyethyl carbamate-(10Me-11F-camptothecin)
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Domaines de recherche:
ZD06519 (7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)) is a camptothecin (HY-16560) analogue and a topoisomerase I inhibitor. ZD06519 is an ADC cytotoxin with a strong bystander effect, inhibiting a variety of malignancies such as HER2-positive and FRα-overexpressing tumors. ZD06519 inhibits DNA cleavage, relaxation, and reconnection processes, inducing tumor cell death. ZD06519 can be used for ADC synthesis and cancer research .
Cat. No.: HY-400770
CAS No.: 1241391-14-9
Synonyms: 1-(2-Amino-4-fluoro-5-methylphenyl)-2-chloroethanone
Domaines de recherche:
MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 (compound 19-2) is an intermediate for the synthesis of MC-GGFG-AM-(10Me-11F-Camptothecin) (HY-153360). Modifying groups can be added group. MC-GGFG-AM-(10Me-11F-Camptothecin) is a drug-linker conjugate used in the synthesis of ADCs .
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Deruxtecan analog 2 (example 9 P3) is a Deruxtecan (HY-13631E) analog. Deruxtecan analog 2 is a agent-linker conjugate composed of Camptothecin (HY-16560) and a linker. Camptothecin (CPT) is a Topo I inhibitor with antineoplastic activity against colorectal, breast, lung and ovarian cancers. Deruxtecan analog 2 can be used for the preparation anti-FGFR2 ADC .
Cat. No.: HY-N8533
CAS No.: 25387-67-1
Category:
Infection Nyssaceae Extract Alkaloids Pyrrole Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Disease Research Fields
Target:
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MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) is a drug-linker conjugate for ADC, formed by conjugation of 7ethanol-10NH2-11F-Camptothecin (HY-156517) with the protease-cleavable MC-GGFG linker. MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) is applicable for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
