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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
116 Results for "
complications
" in MedChemExpress (MCE) Product Catalog:
Products (116)
116 Results for "complications" in MCE Product Catalog:
35
35 Publications Verification
Synonyms: β-Nicotinamide mononucleotide; β-NM; NMN
Category:
Neurological Disease Other disease Anti-aging Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields Cancer
Target:
25
Category:
Cardiovascular Disease Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Labiatae Extract
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5
5 Cited Publications
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O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .
4
4
4 Cited Publications
Synonyms: Kaempferol 3-O-neohesperidoside
Category:
Flavonols Flavonoids Typha orientalis Presl Typhaceae Extract Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
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2
2 Cited Publications
Synonyms: Thiamine chloride hydrochloride; Vitamin B1 hydrochloride
2
2 Cited Publications
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UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications .
2
2 Cited Publications
Cat. No.: HY-50289
CAS No.: 68367-52-2
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Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
2
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Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .
2
2 Cited Publications
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Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .
1
1 Cited Publications
Cat. No.: HY-17374
CAS No.: 22457-89-2
Synonyms: S-Benzoylthiamine O-monophosphate
Research Areas:
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19 .
1
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Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications .
1
1 Cited Publications
Category:
Flavonoids Flavones Phenols Polyphenols Plants Compositae Extract Artemisia capillaris Thunb.
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1
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Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications .
1
1 Cited Publications
Category:
Infection Natural Products Plants Liliaceae Extract Endogenous metabolite Disease Research Fields A．Sativam L. var．Viviparum Regel
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1
1 Cited Publications
Cat. No.: HY-N0309
CAS No.: 114590-20-4
1
1 Cited Publications
Cat. No.: HY-N6845
CAS No.: 19275-46-8
Synonyms: LC15-0444 tartrate
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Research Areas:
Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Cat. No.: HY-F0004S
Synonyms: β-Nicotinamide mononucleotide-d4; β-NM-d4; NMN-d4
Cat. No.: HY-171844
CAS No.: 1086377-48-1
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CX1739 is an orally active, blood-brain barrier permeable, low-efficacy AMPA-glutamate receptor (AMPAR) potentiator. CX1739 enhances excitatory neurotransmission by potentiating glutamate-induced excitatory currents and promoting in vivo long-term potentiation. CX1739 eliminates amphetamine-induced locomotor activity, reverses opioid-, pentobarbital- and ethanol-induced respiratory depression, and exerts pro-cognitive effects in animals. CX1739 impairs motor function recovery and increases the risk of post-injury complications. CX1739 can be used in research related to attention-deficit/hyperactivity disorder, dementia, respiratory depression and spinal cord injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
