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eIF4F complex

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (2) Autophagy (1) Eukaryotic Initiation Factor (eIF) (15) NF-κB (1) SARS-CoV (3)
By Research Areas:	Cancer (14) Infection (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112163

Zotatifin 5+ Cited Publications eFT226	Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis	Infection Cancer
Zotatifin (eFT226) is a potent, selective, and well-tolerated *eIF4A* inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC₅₀=2 nM) and interferes with the assembly of the eIF4F initiation complex . Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC₉₀=37 nM) . Zotatifin induces cell apoptosis .

HY-19560

SBI-0640756 3 Publications Verification SBI-756	Eukaryotic Initiation Factor (eIF) Autophagy	Cancer
SBI-0640756 (SBI-756) is an inhibitor of *eIF4G1* and disrupts the eIF4F complex.

HY-148448

eIF4A3-IN-14	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the *eIF4F* translation complex, with EC₅₀ values of 40 nM and > 2000 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis .

HY-148450

eIF4A3-IN-16	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-16 (compound 60) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-16 inhibits MBA-MB-231cell growth with an EC₅₀ value of 1 nM. eIF4A3-IN-16 interferes the assembling of eIF4F translation complex with a myc-LUC EC₅₀ value of 1 nM and a tub-LUC EC₅₀ value of 30 nM. eIF4A3-IN-16 can be used for triple negative breast cancer (TNBC) research .

HY-148447

eIF4A-IN-3	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A-IN-3, Silvestrol (HY-13251) analogue, is an *eIF4A* inhibitor. eIF4A-IN-3 blocks protein translation initiation by interfering with eIF4F complex assembly, preferentially inhibiting translation of mRNAs with long, highly structured 5'-untranslated regions. eIF4A-IN-3 inhibits proliferation of human breast cancer cells. eIF4A-IN-3 has moderate apical to basolateral permeability in intestinal cell monolayers and a low efflux ratio .

HY-112163A

rel-Zotatifin rel-eFT226	Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis	Infection Cancer
rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated *eIF4A* inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC₅₀=2 nM) and interferes with the assembly of the eIF4F initiation complex .

HY-148443

eIF4A3-IN-9	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the *eIF4F* translation complex, with EC₅₀ values of 29 and 450 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis .

HY-148446

eIF4A3-IN-12	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-12 (compound 62) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of *eIF4F* translation complex with EC₅₀s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis .

HY-148452

eIF4A3-IN-18	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-18 (compound 74) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of *eIF4F* translation complex with EC₅₀ values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC₅₀ of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis .

HY-148444

eIF4A3-IN-10	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-10 (compound 58) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-10 interferes the assembling of *eIF4F* translation complex with EC₅₀s of 35 and 100 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-10 can be used for the research of human cancer pathogenesis .

HY-148451

eIF4A3-IN-17	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-17 (compound 61) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of *eIF4F* translation complex with EC₅₀s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis .

HY-148445

eIF4A3-IN-11	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-11 (compound 56) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-11 interferes the assembling of *eIF4F* translation complex with EC₅₀s of 0.2, 4 and 0.3 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-11 can be used for the research of human cancer pathogenesis .

HY-164524

SBI-0640726	Eukaryotic Initiation Factor (eIF) Akt NF-κB	Cancer
SBI-0640726 is an *eIF4G1* inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the *eIF4F* translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro .

HY-148449

eIF4A3-IN-15	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-15 (compound 52) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of *eIF4F* translation complex with EC₅₀s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis .

HY-182704

SBI-5844 SBI-1275844	Eukaryotic Initiation Factor (eIF) SARS-CoV	Infection
SBI-5844 (SBI-1275844) is a *eIF4F* complex inhibitor and antiviral agent. SBI-5844 disrupts the assembly of the *eIF4F* complex and blocks the interaction between *eIF4E* and *eIF4G. SBI-5844 inhibits the synthesis of HCoV-OC43* nucleocapsid protein and reduces the levels of HCoV-OC43 RNA and total protein. SBI-5844 can be used in studies related to human coronavirus OC43 (HCoV-OC43) infection .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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eIF4F complex

Inhibitors & Agonists