393 Results for "

factor I

" in MedChemExpress (MCE) Product Catalog:
Products (393)

393 Results for "factor I" in MCE Product Catalog:

73
73 Publications Verification
Cat. No.: HY-16560
CAS No.: 7689-03-4
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
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27
27 Cited Publications
Cat. No.: HY-P7018
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Human
Source:  
E. coli
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23
23 Cited Publications
Cat. No.: HY-13012
CAS No.: 446859-33-2
Purity:  99.92%
Synonyms: E-616452; SJN 2511
Research Areas:  

Metabolic Disease

RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
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12
12 Cited Publications
Cat. No.: HY-P7070
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Mouse
Source:  
E. coli
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12
12 Cited Publications
Cat. No.: HY-138298
CAS No.: 1826843-81-5
Purity:  98.90%
Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution)
Research Areas:  

Cancer

Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
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12
12 Cited Publications
Cat. No.: HY-138298A
CAS No.: 1826843-81-5
Purity:  99.58%
Synonyms: T-DXd; DS-8201; DS-8201a
Research Areas:  

Cancer

Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
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9
9 Cited Publications
Cat. No.: HY-P2093
CAS No.: 1083433-49-1
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .
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9
9 Cited Publications
Cat. No.: HY-P2093B
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively .
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7
7 Cited Publications
Cat. No.: HY-P7224
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic factor I; MDNCF; Tumor Necrosis factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic factor; GCP-1; Interleukin 8; Monocyte-Derived Neutrophil Chemotactic factor; Interleukin-8; Monocyte-Derived Neutrophil-Activating Peptide; Emoctakin; Granulocyte Chemotactic Protein 1; AMCF-I; Chemokine (C-X-C Motif) Ligand 8; B-ENAP; SCYB8; TSG-1; LYNAP; 3-10C; LUCT; K60; LECT; Small Inducible Cytokine Subfamily B, Member 8; IL-8; Beta-Thromboglobulin-Like Protein; GCP1; Neutrophil-Activating Protein 1; NAP1; C-X-C Motif Chemokine 8; NAF; C-X-C Motif Chemokine; Beta Endothelial Cell-Derived Neutrophil Activating Peptide; Protein 3-10C; C-X-C Motif Chemokine Ligand 8; Lymphocyte Derived Neutrophil Activating Peptide
Species:  
Human
Source:  
E. coli
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6
6 Cited Publications
Cat. No.: HY-P70788
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Human
Source:  
E. coli
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5
5 Cited Publications
Cat. No.: HY-P70698
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Mouse
Source:  
E. coli
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5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
PACAP (1-38), human, ovine, rat is a PAC1 receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca 2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .
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4
4 Cited Publications
Cat. No.: HY-112951
CAS No.: 2438721-44-7
Purity:  99.91%
Target:  

STING

Research Areas:  

Cancer

ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
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4
4 Cited Publications
Cat. No.: HY-P70576
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating factor, Multiple; Interleukin 3; P-Cell Stimulating factor; IL-3; P-Cell-Stimulating factor; Hematopoietic Growth factor; Mast-Cell Growth factor; MCGF; Mast Cell Growth factor; Multipotential Colony-Stimulating factor; MGC79398; I
Species:  
Human
Source:  
E. coli
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4
4 Cited Publications
Cat. No.: HY-P70569
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic factor I; MDNCF; Tumor Necrosis factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic factor; GCP-1; Interleukin 8; Monocyte-Derived Neutrophil Chemotactic factor; Interleukin-8; Monocyte-Derived Neutrophil-Activating Peptide; Emoctakin; Granulocyte Chemotactic Protein 1; AMCF-I; Chemokine (C-X-C Motif) Ligand 8; B-ENAP; SCYB8; TSG-1; LYNAP; 3-10C; LUCT; K60; LECT; Small Inducible Cytokine Subfamily B, Member 8; IL-8; Beta-Thromboglobulin-Like Protein; GCP1; Neutrophil-Activating Protein 1; NAP1; C-X-C Motif Chemokine 8; NAF; C-X-C Motif Chemokine; Beta Endothelial Cell-Derived Neutrophil Activating Peptide; Protein 3-10C; C-X-C Motif Chemokine Ligand 8; Lymphocyte Derived Neutrophil Activating Peptide
Species:  
Human
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-110135A
Purity:  99.42%
Target:  

IGF-1R

Research Areas:  

Neurological Disease

NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects .
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3
3 Cited Publications
Cat. No.: HY-P7203
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; Insulin Like Growth factor 1; IGF1A; IGF-I; MGF; Insulin-Like Growth factor 1; Insulin-Like Growth factor IB; Insulin-Like Growth factor I; Insulin-Like Growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; Insulin-Like
Species:  
Rat
Source:  
E. coli
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3
3 Cited Publications
Cat. No.: HY-P70685
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3; Colony-Stimulating factor, Multiple; Interleukin 3; P-Cell Stimulating factor; IL-3; P-Cell-Stimulating factor; Hematopoietic Growth factor; Mast-Cell Growth factor; MCGF; Mast Cell Growth factor; Multipotential Colony-Stimulating factor; MGC79398; I
Species:  
Mouse
Source:  
HEK293
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3
3 Cited Publications
Cat. No.: HY-P7379
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL8; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Prev. IL8; Alveolar Macrophage Chemotactic factor I; MDNCF; Tumor Necrosis factor-Induced Gene 1; NAP-1; Neutrophil-Activating Peptide 1; MONAP; T-Cell Chemotactic factor; GCP-1; Interleukin 8
Species:  
Human
Source:  
CHO
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2
2 Cited Publications
Cat. No.: HY-78349
CAS No.: 607737-87-1
Target:  

TGF-β Receptor

Research Areas:  

Cancer

A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM .
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