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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
insulin-like growth factor (IGF)-1
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "insulin-like growth factor (IGF)-1" in MCE Product Catalog:
31
31 Publications Verification
Synonyms: AXL1717; Picropodophyllotoxin; PPP
27
27 Cited Publications
Cat. No.: HY-P7018
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Human
Source:
E. coli
14
Target:
Research Areas:
NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity .
12
12 Cited Publications
Cat. No.: HY-P7070
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Mouse
Source:
E. coli
7
7 Cited Publications
Target:
Research Areas:
GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity .
6
6 Cited Publications
Target:
Research Areas:
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity .
6
6 Cited Publications
Cat. No.: HY-P70788
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Human
Source:
E. coli
5
5 Cited Publications
Synonyms: MK-677 free base; MK-0677 free base
Target:
Research Areas:
Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis .
5
5 Cited Publications
Cat. No.: HY-P70698
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Mouse
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P7203
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Rat
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-B0025
CAS No.: 83480-29-9
Target:
2
2 Cited Publications
Cat. No.: HY-P70783
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P78723
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IGF1R; IGF-I Receptor; insulin like growth factor 1 Receptor; MGC18216; insulin-like growth factor 1 Receptor; insulin-like growth factor I Receptor; JTK13; Receptor Protein-Tyrosine Kinase; CD221; Tyrosine-Protein Kinase Receptor; IGFIR; CD221 Antigen; IGFR; IGF1R Protein
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P99294
CAS No.: 905703-97-1
Synonyms: AMG 479; Human Anti-IGF1R Recombinant Antibody
1
1 Cited Publications
Synonyms: I-OMe-AG 538
Target:
Research Areas:
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM .
1
1 Cited Publications
Cat. No.: HY-P700093AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P700478
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IGF1; Somatomedin-C; insulin like growth factor 1; IGF1A; IGF-I; MGF; insulin-like growth factor 1; insulin-like growth factor IB; insulin-like growth factor I; insulin-like growth factor-I; IGFI; Alternative Protein IGF1; IGF; Somatomedin C; insulin-like
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P99197
CAS No.: 943453-46-1
Synonyms: CP-751871
Cat. No.: HY-18785
CAS No.: 854171-35-0
Target:
Research Areas:
Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.
IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
