62 Results for "

lens crystallin

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "lens crystallin" in MCE Product Catalog:

11
11 Publications Verification
Cat. No.: HY-N0033
CAS No.: 94079-81-9
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .
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2
2 Cited Publications
Cat. No.: HY-N0311
CAS No.: 23313-21-5
Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .
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2 Cited Publications
Cat. No.: HY-N10616
CAS No.: 90-29-9
Pseudobaptigenin is a flavonoid. Pseudobaptigenin shows very good anticataract activity. Pseudobaptigenin has good binding affinity for the inhibition of glycation against γ-crystallin protein. Pseudobaptigenin also has good ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) property .
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1
1 Cited Publications
Cat. No.: HY-15314
CAS No.: 147254-64-6
Purity:  96.10%
Synonyms: AS-3201
Target:  

Aldose Reductase

Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .
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1
1 Cited Publications
Cat. No.: HY-127032
CAS No.: 75345-27-6
Purity:  ≥99.0%
Synonyms: Polidronium chloride
Research Areas:  

Infection

Polyquaternium-1 (Polidronium chloride; PQ-1) is an antimicrobial preservative and an activator of NF-κB. Polyquaternium-1 targets bacterial cell membranes, commonly used in ophthalmic surgery. Polyquaternium-1 adsorbs to the surface of microbial membranes through its polycationic properties, destroying membrane integrity and inducing potassium ion leakage, leading to bacterial death. Polyquaternium-1 exerts antimicrobial effects at a concentration of 0.001% and has low toxicity to mammalian cells. Polyquaternium-1 can be used to prepare products such as glaucoma eye drops (Travoprost preparations containing PQ-1), artificial tears, and contact lens solutions to reduce the ocular surface toxicity of traditional preservatives such as benzalkonium chloride (HY-B2232) .
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1
1 Cited Publications
Cat. No.: HY-D1005B
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 7700 (Average Mn)
Poloxamer 237 (F87) (PEG-PPG-PEG, 7700 (Average Mn)) is an alcohol substance that acts as an oil-in-water emulsifier and solubilizer. Poloxamer 237 (F87) is used in the research of formulations such as contact lens care solutions and eye drops .
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1
1 Cited Publications
Cat. No.: HY-W039865
CAS No.: 19879-84-6
1-Thio-beta-D-glucose tetraacetate exhibits cytotoxicity in cells HeLa and human ocular lens epithelium CECH with IC50s of >250 and >200 μM. 1-Thio-beta-D-glucose tetraacetate reveals moderate anticancer property .
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1
1 Cited Publications
Cat. No.: HY-P7873
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRYAB; Heat-Shock 20 KD Like-Protein; Prev. CRYA2; HEL-S-101; HSPB5; CTRCT16; Alpha-crystallin B Chain; CMD1II; Heat Shock Protein Family B Member 5; CTPP2; Renal Carcinoma Antigen NY-REN-27; MFM2A; Heat Shock Protein Beta-5; MFM2B; Rosenthal Fiber Component; HspB5; Alpha(B)-crystallin; MFM2; Epididymis Secretory Protein Li 101; crystallin Alpha B; crystallin, Alpha B
Species:  
Human
Source:  
E. coli
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1 Cited Publications
Cat. No.: HY-P70933
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPB8; Alpha-crystallin C Chain; Heat Shock Protein Family B (Small) Member 8; Protein Kinase H11; E2IG1; HSPB8-N1; HSP22; HSPB8-N2; CMT2L; DHMN2; H11; HMN2A; Small Stress Protein-Like Protein HSP22; HMND2; Heat Shock Protein Family B Member 8; MFM13; Hea
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-112531
CAS No.: 25249-16-5
Research Areas:  

Others

Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agent and etc .
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Cat. No.: HY-134633
CAS No.: 1808266-58-1
Synonyms: EV 06 chloride; UNR 844 chloride
Target:  

Drug Intermediate

Research Areas:  

Neurological Disease

Alpha-lipoic acid choline ester (EV 06) chloride is choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester chloride reduces the disulfide bond level of lens proteins. Alpha-lipoic acid choline ester chloride improves lens elasticity. Alpha-lipoic acid choline ester chloride is hydrolyzed by ocular esterases to release alpha-lipoic acid and choline. Alpha-lipoic acid choline ester chloride is used for the research of presbyopia .
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Cat. No.: HY-112531A
CAS No.: 25249-16-5
Research Areas:  

Others

Poly(2-hydroxyethyl methacrylate) (MW 1000000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agent and etc .
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Cat. No.: HY-108296
CAS No.: 1043-21-6
Purity:  ≥95.0%
Synonyms: Catalin K
Pirenoxine (Catalin K) is an antioxidant with lens-protective activity. Pirenoxine inhibits lens sclerosis, prevents lipid peroxidation and suppresses lens protein opacification. Pirenoxine blocks benzoquinone acetic acid-induced cataract progression. Pirenoxine can be used in research related to presbyopia and cataracts .
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Cat. No.: HY-W014180
CAS No.: 39145-52-3
N-Acetyl-L-histidine monohydrate, a histidine derivative, is a prominent biomolecule in brain, retina and lens of poikilothermic vertebrates. N-Acetyl-L-histidine monohydrate has a role as an animal metabolite .
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Cat. No.: HY-W089777
CAS No.: 2530-83-8
Synonyms: GPTMS
3-Glycidyloxypropyltrimethoxysilane (GPTMS) is a silicon source for the preparation of inorganic-organic hybrid polymers. 3-Glycidyloxypropyltrimethoxysilane can be used to prepare hard coatings of organic polymers, such as contact lens materials in the optical industry, as well as related materials in the fields of electronics, thin films, sensors, nanoimprinting, waveguides, and biology .
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Cat. No.: HY-NP087
Synonyms: LCA
Lens Culinaris Agglutinin (LCA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) is a biological material or organic compound that can be used in life science research .
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Cat. No.: HY-19738
CAS No.: 185351-19-3
Target:  

Tau Protein

Research Areas:  

Neurological Disease

NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( 41GCWMLY 46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .
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Cat. No.: HY-113033
CAS No.: 124505-87-9
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .
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Cat. No.: HY-NP0180
Synonyms: LCA (Biotinylated)
Lens Culinaris Agglutinin (LCA) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) Biotinylated is a biological material or organic compound that can be used in life science research .
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Cat. No.: HY-W250151
CAS No.: 12627-53-1
Leishman's stain is an essential staining tool for for staining of the peripheral blood and bone marrow smears (displayed pale bluish-grey to deep blue under oil-immersion lens) .
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