Search Result

Results for "

malformation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Amino Acid Derivatives (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apoptosis (8) Aryl Hydrocarbon Receptor (1) Bacterial (2) Biochemical Assay Reagents (1) Caspase (1) CDK (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Dopamine Receptor (4) Drug Derivative (1) DYRK (1) Endogenous Metabolite (4) Environmental Pollutants (5) ERK (2) Fungal (1) Herbicide (6) iGluR (1) Insecticide (3) Interleukin Related (1) Isotope-Labeled Compounds (2) Lysyl Oxidase (1) MDM-2/p53 (1) MEK (2) Mitochondrial Metabolism (1) Notch (1) Parasite (1) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (6) ROCK (2) SARS-CoV (4) Sodium Channel (4) Tie (3) VEGFR (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (10) Infection (8) Inflammation/Immunology (3) Metabolic Disease (7) Neurological Disease (10)

By Targets:

Adrenergic Receptor (3)

Amino Acid Derivatives (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (2)

Apoptosis (8)

Aryl Hydrocarbon Receptor (1)

Bacterial (2)

Biochemical Assay Reagents (1)

Caspase (1)

CDK (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (4)

Drug Derivative (1)

DYRK (1)

Endogenous Metabolite (4)

Environmental Pollutants (5)

ERK (2)

Fungal (1)

Herbicide (6)

iGluR (1)

Insecticide (3)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

Lysyl Oxidase (1)

MDM-2/p53 (1)

MEK (2)

Mitochondrial Metabolism (1)

Notch (1)

Parasite (1)

Ras (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (6)

ROCK (2)

SARS-CoV (4)

Sodium Channel (4)

Tie (3)

VEGFR (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (10)

Infection (8)

Inflammation/Immunology (3)

Metabolic Disease (7)

Neurological Disease (10)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0263

Thiabendazole 4 Publications Verification Tiabendazole; 2-(4-Thiazolyl)benzimidazole	Environmental Pollutants Mitochondrial Metabolism Parasite Caspase VEGFR MDM-2/p53 CDK Interleukin Related	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling .

HY-121161A

Brassinazole 2 Publications Verification	Cytochrome P450	Others
Brassinazole is a selective triazole-type brassinosteroid (BR) biosynthesis inhibitor. Brassinazole is used for regulating plant growth and development .

HY-W011689

6PPD 1 Publications Verification	Reactive Oxygen Species (ROS)	Others
6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos .

HY-127009

Levoleucovorin Levofolinic acid; Levofolene	Lysyl Oxidase Apoptosis	Metabolic Disease Cancer
Levoleucovorin (Levofolinic acid; Levofolene) is the pharmacologically and orally active levoisomer of Folinic acid (HY-17556), a synthetic folate analogue. Levoleucovorin can inhibit LOXL2 with an IC₅₀ of 68.81 μM. Levoleucovorin can inhibit cancer cells proliferation, migration and induce apoptosis. Levoleucovorin can be used as a rescue agent for high-dose Methotrexate (HY-14519). Levoleucovorin can reduce the frequency of embryonic malformations. Levoleucovorin can be used for the research of can and endocrinology, such as breast cancer and osteosarcoma .

HY-170316

Ibetazol	Ras	Cancer
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .

HY-162596

NRL-1049 BA-1049 free base	ROCK	Neurological Disease
NRL-1049 (BA-1049 (free base)) is an orally available and selective ROCK2 inhibitor with IC₅₀ values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .

HY-A0081

Fluphenazine dihydrochloride 3 Publications Verification	Dopamine Receptor SARS-CoV Sodium Channel	Neurological Disease Cancer
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-B1238

Pronethalol 2 Publications Verification (±)-Pronethalo	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) .

HY-A0199

Sodium tetradecyl sulfate (27% in water) Tergitol 4	Environmental Pollutants Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Sodium tetradecyl sulfate (Tergitol 4) is a novel scleroembolic agent and an apoptosis inducer. Sodium tetradecyl sulfate can be used for research on varicose veins and vascular malformation diseases .

HY-N6786

Ochratoxin B	Endogenous Metabolite	Metabolic Disease
Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-W019815

N-Ethyl-N-nitrosourea ENU; N-Nitroso-N-ethylurea	DNA/RNA Synthesis	Neurological Disease Cancer
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders .

HY-119980

Fluphenazine 3 Publications Verification	Sodium Channel Dopamine Receptor SARS-CoV	Infection Neurological Disease Cancer
Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-W040194

Clomazone	Environmental Pollutants Herbicide	Metabolic Disease
Clomazone is a broad spectrum herbicide, mainly used to control annual broadleaf weeds and grass weeds in various crops such as rice, soybeans, and peanuts. Clomazone inhibits carotenoid biosynthesis, and treated plants show typical "albinism" symptoms due to the destruction of chloroplast membrane structure leading to chlorophyll degradation. Clomazone exhibits multiple toxic effects on non-target organisms, including aquatic lethality, developmental malformations, liver damage, mitochondrial dysfunction, and hematotoxicity .

HY-B1853

Simetryn	Environmental Pollutants Apoptosis ERK Herbicide MEK	Cardiovascular Disease
Simetryn is a triazine herbicide that exerts teratogenicity. Simetryn inhibits photosynthesis by blocking electron transfer in the chloroplast photosystem II and activates the MEK/Erk signaling pathway. Simetryn triggers vascular and developmental abnormalities in zebrafish and tadpoles, suppresses proliferation, enhances apoptosis, and induces malformations. Simetryn serves as a tool to establish a zebrafish model for studying arteriovenous malformations and related pathogenesis. Simetryn controls paddy weeds and can be used for research on developmental and vascular disorders .

HY-133204

Chlorfluazuron IKI-7899	Environmental Pollutants Insecticide	Others
Chlorfluazuron (IKI-7899) is a benzoylurea insecticide. Chlorfluazuron inhibts insect chitin and disrupts normal exuviation by inducing malformations, thereby preventing and controlling lepidopteran pests .

HY-21200

Perfluoroheptanesulfonic acid 1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS	iGluR	Infection
Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). PFHpS can induce malformations in zebrafish larvae (EC₅₀=168.1 μM). It has also been found in landfill leachate, and fetal exposure to PFHpS can lead to reduced birth weight.

HY-W343900

Hydroxyproline DL-Hydroxyproline	Amino Acid Derivatives	Metabolic Disease
Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagen tissue. Hydroxyproline can be used in research on endocrine and metabolic diseases, as well as genetic diseases and malformations. Hydroxyproline can also serve as a biomarker .

HY-136439

4-Epianhydrotetracycline hydrochloride	Bacterial Antibiotic Apoptosis	Infection
4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively .

HY-108475

ProINDY	DYRK	Cancer
ProINDY, a prodrug of INDY (HY-108476), is a DYRK1A and DYRK1B inhibitor. ProINDY effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression .

HY-171985

DCPD	Biochemical Assay Reagents	Others
DCPD is an amine compound. DCPD has significant embryotoxicity with an ED₅₀ of 0.6 μmol per egg for chick embryos, and it induces embryos deaths and malformations. DCPD can be used for human teratogenesis research .

HY-B1238A

Pronethalol hydrochloride (±)-Pronethalo hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs) .

HY-B1238R

Pronethalol (Standard) (±)-Pronethalo (Standard)	Adrenergic Receptor Reference Standards	Cardiovascular Disease Neurological Disease
Pronethalol (Standard) is the analytical standard of Pronethalol. This product is intended for research and analytical applications. Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) .

HY-E70782

TIE2 R849W Recombinant Human Active Protein Kinase	Tie	Cardiovascular Disease
TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 R849W is the most common mutation implicated in an inherited form of vascular malformations. TIE2 R849W Recombinant Human Active Protein Kinase is a recombinant TIE2 R849W protein that can be used to study TIE2 R849W-related functions .

HY-B1853R

Simetryn (Standard)	Herbicide Reference Standards ERK MEK Apoptosis	Cardiovascular Disease
Simetryn (Standard) is the analytical standard of Simetryn (HY-B1853). This product is intended for research and analytical applications. Simetryn is a triazine herbicide that exerts teratogenicity. Simetryn inhibits photosynthesis by blocking electron transfer in the chloroplast photosystem II and activates the MEK/Erk signaling pathway. Simetryn triggers vascular and developmental abnormalities in zebrafish and tadpoles, suppresses proliferation, enhances apoptosis, and induces malformations. Simetryn serves as a tool to establish a zebrafish model for studying arteriovenous malformations and related pathogenesis. Simetryn controls paddy weeds and can be used for research on developmental and vascular disorders .

HY-133204R

Chlorfluazuron (Standard) IKI-7899 (Standard)	Insecticide Reference Standards	Others
Chlorfluazuron (Standard) is the analytical standard of Chlorfluazuron. This product is intended for research and analytical applications. Chlorfluazuron (IKI-7899) is a benzoylurea insecticide. Chlorfluazuron inhibts insect chitin and disrupts normal exuviation by inducing malformations, thereby preventing and controlling lepidopteran pests .

HY-W774881

Thiabendazole-d6 Tiabendazole-d₆; 2-(4-Thiazolyl)benzimidazole-d₆	Isotope-Labeled Compounds	Others
Thiabendazole-d₆ is a deuterated labeled Thiabendazole (HY-B0263). Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling .

HY-105578A

Letimide hydrochloride MA 1143 hydrochloride	Endogenous Metabolite	Inflammation/Immunology
Letimide hydrochloride (MA 1143 hydrochloride) is an analgesic with potent analgesic activity. Letimide hydrochloride has shown cytogenetic effects on human lymphocytes in in vitro experiments. Letimide hydrochloride did not exhibit significant chromosomal aberrations or sister chromatid exchanges in in vivo studies in mouse bone marrow cells. Teratogenic studies conducted on mice with Letimide hydrochloride also did not show obvious effects on inducing congenital malformations .

HY-N6786R

Ochratoxin B (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
Ochratoxin B (Standard) is the analytical standard of Ochratoxin B (HY-N6786). This product is intended for research and analytical applications. Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-N6786S

Ochratoxin B-13C20	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Ochratoxin B- ¹³C₂₀ is ¹³C-labeled Ochratoxin B (HY-N6786). Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-E70784

TIE2 Y897S Recombinant Human Active Protein Kinase	Tie	Cardiovascular Disease
TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 Y897S is the most mutation of TIE2. TIE2 Y897S Recombinant Human Active Protein Kinase is a recombinant TIE2 Y897S protein that can be used to study TIE2 Y897S-related functions .

HY-E70783

TIE2 Y1108F Recombinant Human Active Protein Kinase	Tie	Cardiovascular Disease
TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 Y1108F is the most mutation of TIE2. TIE2 Y1108F Recombinant Human Active Protein Kinase is a recombinant TIE2 Y1108F protein that can be used to study TIE2 Y1108F-related functions .

HY-W040194R

Clomazone (Standard)	Herbicide Reference Standards	Metabolic Disease
Clomazone (Standard) is the analytical standard of Clomazone (HY-W040194). This product is intended for research and analytical applications. Clomazone is a broad spectrum herbicide, mainly used to control annual broadleaf weeds and grass weeds in various crops such as rice, soybeans, and peanuts. Clomazone inhibits carotenoid biosynthesis, and treated plants show typical "albinism" symptoms due to the destruction of chloroplast membrane structure leading to chlorophyll degradation. Clomazone exhibits multiple toxic effects on non-target organisms, including aquatic lethality, developmental malformations, liver damage, mitochondrial dysfunction, and hematotoxicity.

HY-136439R

4-Epianhydrotetracycline hydrochloride (Standard)	Reference Standards Bacterial Antibiotic Apoptosis	Infection
4-Epianhydrotetracycline hydrochloride (Standard) is the analytical standard of 4-Epianhydrotetracycline hydrochloride. This product is intended for research and analytical applications. 4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively .

HY-119980A

Fluphenazine dimaleate	Dopamine Receptor Sodium Channel SARS-CoV	Infection Neurological Disease Cancer
Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-119980B

Fluphenazine hydrochloride	Dopamine Receptor Sodium Channel SARS-CoV	Neurological Disease Cancer
Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-N9367

Soladulcidine	Fungal	Infection Cancer
Soladulcidine, as an anticancer steroidal alkaloid, possesses antifungal and induction of congenital craniofacial malformation activities .

HY-W714973

Halauxifen-methyl	Herbicide	Others
Halauxifen-methyl is a 6-arylpicolinic acid herbicide. As a synthetic auxin, Halauxifen-methyl interferes with the normal growth and development of sensitive weeds by mimicking the action of endogenous plant auxins, causing malformation, uncontrolled growth and eventual death .

HY-162596A

(Rac)-NRL-1049 dihydrochloride (Rac)-BA-1049	ROCK	Neurological Disease
(Rac)-NRL-1049 is the racemic mixture of NRL-1049 (BA-1049 (free base)) (HY-162596). NRL-1049 is an orally available and selective ROCK2 inhibitor with IC₅₀ values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .

HY-N18081

22-Oxo-20-hydroxyecdysone 22-Dehydro-20-hydroxyecdysone	Drug Derivative	Others
22-Oxo-20-hydroxyecdysone is a phytoecdysteroid, found in Serratula tinctoria (Asteraceae). 22-Oxo-20-hydroxyecdysone triggers supernumerary moulting and leg, mouth part malformations in Ornithodoros moubata females .

HY-B2052A

Thiosultap monosodium Monosultap	Insecticide Angiotensin-converting Enzyme (ACE) Apoptosis	Infection
Thiosultap monosodium (Monosultap) is a broad-spectrum insecticide and a competitive inhibitor of acetylcholine. Thiosultap monosodium exerts contact and stomach poisoning effects through systemic conduction in field pests. Thiosultap monosodium has teratogenic effects, induces notochord malformations in zebrafish embryos, and causes apoptosis and abnormally elevated cell proliferation in partial notochord tissues of zebrafish. Thiosultap monosodium is applicable to the research of controlling rice stem borers .

HY-W714200

Neburon	Herbicide Aryl Hydrocarbon Receptor Notch Apoptosis	Others
Neburon is a phenylurea herbicide whose main mechanism of action is to inhibit photosynthetic electron transport, thereby disrupting algal growth. Neburon activates the Ahr and Notch1 signaling pathways, and induces oxidative stress and apoptosis. Long-term exposure causes significant male reproductive toxicity and cardiotoxicity in zebrafish .

Cat. No.	Product Name	Category	Target	Chemical Structure