91 Results for "

osteogenic

" in MedChemExpress (MCE) Product Catalog:
Products (91)

91 Results for "osteogenic" in MCE Product Catalog:

17
L-Tryptophan
L-Tryptophan
0 Images
17 Publications Verification
Cat. No.: HY-N0623
CAS No.: 73-22-3
Synonyms: Tryptophan; Tryptophane
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants

L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels .
loading...
    loading...
View All Sizes
12
L-Glutamine-13C5
L-Glutamine-13C5
0 Images
12 Cited Publications
Cat. No.: HY-N0390S1
CAS No.: 184161-19-1
Synonyms: L-Glutamic acid 5-amide-13C5
L-Glutamine- 13C5 is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
loading...
    loading...
View All Sizes
12
Corylin
Corylin
0 Images
12 Cited Publications
Cat. No.: HY-N0236
CAS No.: 53947-92-5
Category:  

Infection Flavonoids Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Disease Research Fields Isoflavones

Target:  

Antibiotic STAT

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways .
loading...
    loading...
View All Sizes
11
L-Ascorbic acid 2-phosphate magnesium
L-Ascorbic acid 2-phosphate magnesium
0 Images
11 Cited Publications
Cat. No.: HY-103701A
CAS No.: 113170-55-1
Purity:  99.97%
Synonyms: 2-Phospho-L-ascorbic acid magnesium; LAA2P magnesium
Category:  

Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .
loading...
    loading...
View All Sizes
11
L-Ascorbic acid 2-phosphate trisodium
L-Ascorbic acid 2-phosphate trisodium
0 Images
11 Cited Publications
Cat. No.: HY-107837
CAS No.: 66170-10-3
Purity:  99.45%
Synonyms: 2-Phospho-L-ascorbic acid trisodium
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite

L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .
loading...
    loading...
View All Sizes
11
L-Ascorbic acid 2-phosphate
L-Ascorbic acid 2-phosphate
0 Images
11 Cited Publications
Cat. No.: HY-103701
CAS No.: 23313-12-4
Purity:  36.8%
Synonyms: 2-Phospho-L-ascorbic acid; LAA2P
Category:  

Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .
loading...
    loading...
View All Sizes
11
L-Ascorbic acid 2-phosphate magnesium hydrate
L-Ascorbic acid 2-phosphate magnesium hydrate
0 Images
11 Cited Publications
Cat. No.: HY-103701B
CAS No.: 1713265-25-8
Purity:  99.63
Synonyms: 2-Phospho-L-ascorbic acid magnesium hydrate; LAA2P magnesium hydrate
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .
loading...
    loading...
View All Sizes
6
AS2863619
AS2863619
0 Images
6 Cited Publications
Cat. No.: HY-126675A
CAS No.: 2241300-51-4
Purity:  99.94%
Target:  

STAT CDK Apoptosis TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

AS2863619 is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets Stat5a-CDK8/19 to promote the differentiation of CD4 + T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects .
loading...
    loading...
View All Sizes
6
AS2863619 free base
AS2863619 free base
0 Images
6 Cited Publications
Cat. No.: HY-126675
CAS No.: 2241300-50-3
Purity:  99.68%
Target:  

CDK TGF-beta/Smad Apoptosis STAT

Research Areas:  

Inflammation/Immunology

AS2863619 free base is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 free base targets Stat5a-CDK8/19 to promote the differentiation of CD4 + T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 free base also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 free base exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 free base can be applied to research in related fields such as periodontitis-induced bone defects .
loading...
    loading...
View All Sizes
5
20(S)-Hydroxycholesterol
20(S)-Hydroxycholesterol
0 Images
5 Cited Publications
Cat. No.: HY-12316
CAS No.: 516-72-3
Purity:  99.29%
Synonyms: 20α-Hydroxycholesterol
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Smo Endogenous Metabolite

20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .
loading...
    loading...
View All Sizes
4
L-Glutamine-15N-1
L-Glutamine-15N-1
0 Images
4 Cited Publications
Cat. No.: HY-N0390S9
CAS No.: 59681-32-2
Synonyms: L-Glutamic acid 5-amide-15N-1
L-Glutamine- 15N-1 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
loading...
    loading...
View All Sizes
4
Isomangiferin
Isomangiferin
0 Images
4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
Category:  

Infection Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields

Target:  

VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .
loading...
    loading...
View All Sizes
3
L-Glutamine-15N
L-Glutamine-15N
0 Images
3 Cited Publications
Cat. No.: HY-N0390S
CAS No.: 80143-57-3
Synonyms: L-Glutamic acid 5-amide-15N
L-Glutamine- 15N is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
loading...
    loading...
View All Sizes
3
Mollugin
Mollugin
0 Images
3 Cited Publications
Cat. No.: HY-N0316
CAS No.: 55481-88-4
Category:  

Monophenols Terpenoids Sesquiterpenes Rubiaceae Phenols Plants Disease Research Fields Cancer Rubia cordifolia L.

Target:  

JAK NF-κB Reactive Oxygen Species (ROS) Apoptosis VEGFR c-Myc

Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .
loading...
    loading...
View All Sizes
3
Denosumab (anti-TNFSF11)
Denosumab (anti-TNFSF11)
0 Images
3 Cited Publications
Cat. No.: HY-P9958A
CAS No.: 615258-40-7

Target:  

RANKL/RANK Apoptosis NF-κB

Research Areas:  

Neurological Disease Endocrinology Cancer

Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .
loading...
    loading...
View All Sizes
2
Osteogenic Growth Peptide, OGP
Osteogenic Growth Peptide, OGP
0 Images
2 Cited Publications
Cat. No.: HY-P1563
CAS No.: 132996-61-3
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.
loading...
    loading...
View All Sizes
2
L-Tryptophan (standard)
L-Tryptophan (standard)
0 Images
2 Cited Publications
Cat. No.: HY-N0623R
CAS No.: 73-22-3
Synonyms: Tryptophan (standard); Tryptophane (standard)
Category:  

Alkaloids Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Others Reference Standards

L-Tryptophan (standard) is the analytical standard of L-Tryptophan. L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels .
loading...
    loading...
View All Sizes
2
TFMB-(S)-2-HG
TFMB-(S)-2-HG
0 Images
2 Cited Publications
Cat. No.: HY-129079A
CAS No.: 1445703-64-9
Purity:  99.79%
Target:  

DNA Methyltransferase Wnt β-catenin

Research Areas:  

Endocrinology Cancer

TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML) .
loading...
    loading...
View All Sizes
1
Bimekizumab
Bimekizumab
0 Images
1 Cited Publications
Cat. No.: HY-P99280
CAS No.: 1418205-77-2
Synonyms: CDP4940; UCB-4940

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation .
loading...
    loading...
View All Sizes
1
L-Glutamine-15N2
L-Glutamine-15N2
0 Images
1 Cited Publications
Cat. No.: HY-N0390S8
CAS No.: 204451-48-9
Synonyms: L-Glutamic acid 5-amide-15N2
L-Glutamine- 15N2 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na +-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .
loading...
    loading...
View All Sizes
Assay Types