4 Results for "

osteosarcoma and liver cancer

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "osteosarcoma and liver cancer" in MCE Product Catalog:

1
Alizarin
Alizarin
0 Images
1 Cited Publications
Cat. No.: HY-N0563
CAS No.: 72-48-0
Category:  

Quinones Anthraquinones Other Diseases Rubiaceae Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L.

Target:  

AMPK VEGFR PI3K Akt NF-κB Cytochrome P450

Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .
loading...
    loading...
View All Sizes
1
Veratramine
Veratramine
0 Images
1 Cited Publications
Cat. No.: HY-N0837
CAS No.: 60-70-8
Synonyms: NSC17821; NSC23880
Category:  

Alkaloids Piperidine Alkaloids other families Plants Disease Research Fields Cancer

Target:  

PI3K Akt mTOR Autophagy Apoptosis

Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .
loading...
    loading...
View All Sizes
Veratramine (Standard)
Veratramine (Standard)
0 Images
Cat. No.: HY-N0837R
CAS No.: 60-70-8
Synonyms: NSC17821 (Standard); NSC23880 (Standard)
Category:  

Alkaloids Piperidine Alkaloids other families Plants

Target:  

Reference Standards PI3K Akt mTOR Autophagy Apoptosis

Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .
loading...
    loading...
View All Sizes
Attenuatumione H
Attenuatumione H
0 Images
Cat. No.: HY-N21677
CAS No.: 2172833-78-0
Category:  

Natural Products Hypericum attenuatum Fisch. ex Choisy Hypericaceae Plants

Target:  

Drug Derivative

Attenuatumione H is a polycyclic polyprenylated acylphloroglucinol compound found in the whole plant of Hypericum attenuatum, and it exhibits antitumor activity. Attenuatumione H exerts cytotoxic effects on liver cancer cells and breast cancer cells. Attenuatumione H shows no significant inhibitory effect on LPS-induced NO production in macrophages and displays no significant cytotoxic activity against osteosarcoma cells. Attenuatumione H can be used in cancer research .
loading...
    loading...
View All Sizes
Assay Types